To Evaluate Efficacy and Safety of Parsaclisib and Ruxolitinib in Participants With Myelofibrosis Who Have Suboptimal Response to Ruxolitinib (LIMBER-304)
Public ClinicalTrials.gov record NCT04551053. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-Blind, Placebo-Controlled Study of the PI3Kδ Inhibitor Parsaclisib Plus Ruxolitinib in Participants With Myelofibrosis Who Have Suboptimal Response to Ruxolitinib
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of the study is to compare the efficacy and safety of parsaclisib when combined with ruxolitinb versus placebo combined with ruxolitinib in participants with myelofibrosis who have suboptimal response while receiving ruxolitinib monotherapy.
Study identification
- NCT ID
- NCT04551053
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 177 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 26, 2021 (Actual)
- Primary completion
- Aug 16, 2023 (Actual)
- Completion
- Aug 21, 2024 (Actual)
- Last update posted
- Oct 2, 2025
2021 – 2024
United States locations
- U.S. sites
- 35
- U.S. states
- 18
- U.S. cities
- 30
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Sutter Health Alta Bates Summit Medical Center Absmc Alta Bates Summit Comprehensive Cancer Center | Berkeley | California | 94704 | — |
| CCARE | Fresno | California | 93720 | — |
| California Research Institute (Cri) | Los Angeles | California | 90027-6005 | — |
| Emad Ibrahim Md Inc | Redlands | California | 92373 | — |
| Scripps Clinic | San Diego | California | 92103 | — |
| Coastal Integrated Cancer Care - Cicc | San Luis Obispo | California | 93401 | — |
| Stamford Hospital - Medical Oncology Hematology | Stamford | Connecticut | 06904 | — |
| Georgetown University | Washington D.C. | District of Columbia | 20057 | — |
| Emory University | Atlanta | Georgia | 30322 | — |
| Augusta University - Medical College of Georgia | Augusta | Georgia | 30912 | — |
| Indiana University Melvin and Bren Simon Cancer Center | Indianapolis | Indiana | 46202 | — |
| University of Kansas Hospital Authority | Westwood | Kansas | 66205 | — |
| Tulane University | New Orleans | Louisiana | 70112 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| Midamerica Cancer Care | Kansas City | Missouri | 64114 | — |
| New Jersey Hematology Oncology Associates Llc | Brick | New Jersey | 08724 | — |
| Morristown Medical Center - Atlantic Health System | Morristown | New Jersey | 07960 | — |
| Westchester Medical Center Advanced Oncology | Hawthorne | New York | 10532 | — |
| Mount Sinai School of Medicine | New York | New York | 10029 | — |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | — |
| Montefiore Medical Center | The Bronx | New York | 10467 | — |
| Advent Health Hendersonville Park Ridge Hospital Hendersonville | Clyde | North Carolina | 28721 | — |
| Duke Cancer Center | Durham | North Carolina | 27710 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| Oregon Health & Science University | Columbus | Ohio | 43210 | — |
| Oregon Health & Science University | Portland | Oregon | 97239 | — |
| Hillman Cancer Center | Pittsburgh | Pennsylvania | 15232 | — |
| Baptist Cancer Center | Memphis | Tennessee | 38120 | — |
| Texas Oncology - Medical City Dallas | Dallas | Texas | 75230 | — |
| Texas Oncology - Baylor Sammons Cancer Center | Dallas | Texas | 75246-2092 | — |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390-8565 | — |
| Renovatio Clinical | Houston | Texas | 77005 | — |
| Kelsey Seybold Clinic | Houston | Texas | 77025 | — |
| Providence Regional Medical Center Everett | Everett | Washington | 98201 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 142 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04551053, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 2, 2025 · Synced Oct 23, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04551053 live on ClinicalTrials.gov.