To Evaluate the Efficacy and Safety of Parsaclisib and Ruxolitinib in Participants With Myelofibrosis (LIMBER-313)
Public ClinicalTrials.gov record NCT04551066. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of the Combination of PI3Kδ Inhibitor Parsaclisib and Ruxolitinib in Participants With Myelofibrosis
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of the study is to compare the efficacy of parsaclisib when combined with ruxolitinb versus placebo combined with ruxolitinib in participants with myelofibrosis.
Study identification
- NCT ID
- NCT04551066
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 252 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 24, 2021 (Actual)
- Primary completion
- Aug 3, 2023 (Actual)
- Completion
- Nov 25, 2024 (Actual)
- Last update posted
- Oct 21, 2025
2021 – 2024
United States locations
- U.S. sites
- 36
- U.S. states
- 20
- U.S. cities
- 32
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Alaska Oncology and Hematology | Anchorage | Alaska | 99508 | — |
| Mayo Clinic Rochester | Phoenix | Arizona | 85054 | — |
| Sutter Health Alta Bates Summit Medical Center Absmc Alta Bates Summit Comprehensive Cancer Center | Berkeley | California | 94704 | — |
| CCARE | Fresno | California | 93720 | — |
| California Research Institute (Cri) | Los Angeles | California | 90027-6005 | — |
| UCLA School of Medicine | Los Angeles | California | 90095-3075 | — |
| Scripps Clinic | San Diego | California | 92103 | — |
| Coastal Integrated Cancer Care-Cicc | San Luis Obispo | California | 93401 | — |
| Stamford Hospital-Medical Oncology Hematology | Stamford | Connecticut | 06904 | — |
| Georgetown University | Washington D.C. | District of Columbia | 20057 | — |
| Emory University | Atlanta | Georgia | 30322 | — |
| University of Kansas Hospital Authority | Westwood | Kansas | 66205 | — |
| University of Kentucky-Markey Cancer Center | Lexington | Kentucky | 40536 | — |
| Tulane University | New Orleans | Louisiana | 70112 | — |
| Johns Hopkins University | Baltimore | Maryland | 21287 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Midamerica Cancer Care | Kansas City | Missouri | 64114 | — |
| New Jersey Hematology Oncology Associates Llc | Brick | New Jersey | 08724 | — |
| Morristown Medical Center-Atlantic Health System | Morristown | New Jersey | 07960 | — |
| Roswell Park Cancer Institute | Buffalo | New York | 14263 | — |
| Westchester Medical Center Advanced Oncology and Infusion Center | Hawthorne | New York | 10532 | — |
| Mount Sinai School of Medicine | New York | New York | 10029 | — |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | — |
| Montefiore Medical Center | The Bronx | New York | 10467 | — |
| Duke Cancer Center | Durham | North Carolina | 27710 | — |
| Wake Forest Baptist Medical Center | Winston-Salem | North Carolina | 27157 | — |
| Ohio State University | Columbus | Ohio | 43210 | — |
| Kaiser Permanente-Northwest | Portland | Oregon | 97227 | — |
| Oregon Health & Science University | Portland | Oregon | 97239 | — |
| Avera Cancer Institute | Sioux Falls | South Dakota | 57103 | — |
| Texas Oncology-Baylor Sammons Cancer Center | Dallas | Texas | 75246-2092 | — |
| Kelsey Seybold Clinic | Houston | Texas | 77025 | — |
| Houston Methodist Hospital | Houston | Texas | 77030 | — |
| Renovatio Clinical | Spring | Texas | 77380 | — |
| Providence Regional Medical Center Everett | Everett | Washington | 98201 | — |
| Seattle Cancer Care Alliance | Seattle | Washington | 98109 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 141 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04551066, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 21, 2025 · Synced Oct 29, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04551066 live on ClinicalTrials.gov.