Study of Zifibancimig in Participants With Neovascular Age-related Macular Degeneration
Public ClinicalTrials.gov record NCT04567303. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Three-part, Phase I/II Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Efficacy of Zifibancimig Following Intravitreal Administration of Multiple Ascending Doses and Continuous Delivery From the Port Delivery in Patients With Neovascular Age-related Macular Degeneration
Study identification
- NCT ID
- NCT04567303
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Lead sponsor
- Hoffmann-La Roche
- Industry
- Enrollment
- 177 participants
Conditions and interventions
Conditions
Interventions
- Port Delivery Platform Device
- Ranibizumab Drug
- Zifibancimig Drug
Device · Drug
Eligibility (public fields only)
- Age range
- 50 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 27, 2020
- Primary completion
- Jul 31, 2026
- Completion
- Jul 31, 2026
- Last update posted
- May 5, 2026
2020 – 2026
United States locations
- U.S. sites
- 38
- U.S. states
- 22
- U.S. cities
- 37
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Barnet Dulaney Perkins Eye Center | Mesa | Arizona | 85206 | — |
| Associated Retina Consultants | Phoenix | Arizona | 85020 | — |
| The Retina Partners | Encino | California | 91436 | — |
| Retinal Consultants Med Group | Sacramento | California | 95841 | — |
| Orange County Retina Med Group | Santa Ana | California | 92705 | — |
| Southwest Retina Consultants | Durango | Colorado | 81303 | — |
| Retina Vitreous Assoc of FL | St. Petersburg | Florida | 33711 | — |
| Southern Vitreoretinal Assoc | Tallahassee | Florida | 32308 | — |
| Retina Associates of Florida, LLC | Tampa | Florida | 33609 | — |
| Southeast Retina Center | Augusta | Georgia | 30909 | — |
| University Retina and Macula Associates, PC | Oak Forest | Illinois | 60452 | — |
| Maine Eye Center | Portland | Maine | 04101 | — |
| Johns Hopkins Med | Baltimore | Maryland | 21287 | — |
| Retina Group of Washington | Chevy Chase | Maryland | 20815 | — |
| Cumberland Valley Retina Consultants | Hagerstown | Maryland | 21740 | — |
| Foundation for Vision Research | Grand Rapids | Michigan | 49546 | — |
| Associated Retinal Consultants | Royal Oak | Michigan | 48073 | — |
| VitreoRetinal Surgery, PLLC. | Saint Louis Park | Minnesota | 55416 | — |
| The Retina Institute | St Louis | Missouri | 63128 | — |
| Sierra Eye Associates | Reno | Nevada | 89502 | — |
| Envision Ocular, LLC | Bloomfield | New Jersey | 07003 | — |
| Retina Vit Surgeons/Central NY | Liverpool | New York | 13088 | — |
| Duke Eye Center | Durham | North Carolina | 27705 | — |
| Graystone Eye | Hickory | North Carolina | 28602 | — |
| OSU Eye Physicians & Surgeons | Columbus | Ohio | 43212 | — |
| Mid Atlantic Retina - Wills Eye Hospital | Philadelphia | Pennsylvania | 19107 | — |
| Carolina Eyecare Physicians | Mt. Pleasant | South Carolina | 29464 | — |
| Charles Retina Institute | Germantown | Tennessee | 38138 | — |
| Southeastern Retina Associates | Knoxville | Tennessee | 37922 | — |
| Tennessee Retina PC. | Nashville | Tennessee | 37203 | — |
| Austin Research Center for Retina | Austin | Texas | 78705 | — |
| Austin Clinical Research LLC | Austin | Texas | 78750 | — |
| Retina Consultants of Texas | Bellaire | Texas | 77401 | — |
| Retina Consultants of Texas | Houston | Texas | 77030 | — |
| Retina Center of Texas | Southlake | Texas | 76092 | — |
| Piedmont Eye Center | Lynchburg | Virginia | 24502 | — |
| Wagner Kapoor Institute | Norfolk | Virginia | 23502 | — |
| Spokane Eye Clinical Research | Spokane | Washington | 99204 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04567303, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 5, 2026 · Synced May 6, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04567303 live on ClinicalTrials.gov.