Study of Zifibancimig in Participants With Neovascular Age-related Macular Degeneration
Public ClinicalTrials.gov record NCT04567303. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Three-part, Phase I/II Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Efficacy of Zifibancimig Following Intravitreal Administration of Multiple Ascending Doses and Continuous Delivery From the Port Delivery in Patients With Neovascular Age-related Macular Degeneration
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a first in-human study to investigate the safety, tolerability and efficacy of zifibancimig administered through intravitreal (IVT) injections and via the port delivery (PD) implant in participants with neovascular age-related macular degeneration (nAMD).
Study identification
- NCT ID
- NCT04567303
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Enrollment
- 177 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 50 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 28, 2020 (Actual)
- Primary completion
- Aug 25, 2026 (Actual)
- Completion
- Aug 25, 2026 (Actual)
- Last update posted
- Sep 14, 2026
2020 – 2026
United States locations
- U.S. sites
- 36
- U.S. states
- 22
- U.S. cities
- 35
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Barnet Dulaney Perkins Eye Center | Mesa | Arizona | 85206 | — |
| Associated Retina Consultants | Phoenix | Arizona | 85020 | — |
| The Retina Partners | Encino | California | 91436 | — |
| Retinal Consultants Med Group | Sacramento | California | 95841 | — |
| Orange County Retina Med Group | Santa Ana | California | 92705 | — |
| Southwest Retina Consultants | Durango | Colorado | 81303 | — |
| Retina Vitreous Assoc of FL | St. Petersburg | Florida | 33711 | — |
| Southern Vitreoretinal Assoc | Tallahassee | Florida | 32308 | — |
| Southeast Retina Center | Augusta | Georgia | 30909 | — |
| University Retina and Macula Associates, PC | Oak Forest | Illinois | 60452 | — |
| Maine Eye Center | Portland | Maine | 04101 | — |
| Johns Hopkins Med | Baltimore | Maryland | 21287 | — |
| Retina Group of Washington | Chevy Chase | Maryland | 20815 | — |
| Cumberland Valley Retina Consultants | Hagerstown | Maryland | 21740 | — |
| Foundation for Vision Research | Grand Rapids | Michigan | 49546 | — |
| Associated Retinal Consultants | Royal Oak | Michigan | 48073 | — |
| VitreoRetinal Surgery, PLLC. | Saint Louis Park | Minnesota | 55416 | — |
| The Retina Institute | St Louis | Missouri | 63128 | — |
| Sierra Eye Associates | Reno | Nevada | 89502 | — |
| Envision Ocular, LLC | Bloomfield | New Jersey | 07003 | — |
| Retina Vit Surgeons/Central NY | Liverpool | New York | 13088 | — |
| Duke Eye Center | Durham | North Carolina | 27705 | — |
| Graystone Eye | Hickory | North Carolina | 28602 | — |
| OSU Eye Physicians & Surgeons | Columbus | Ohio | 43212 | — |
| Mid Atlantic Retina - Wills Eye Hospital | Philadelphia | Pennsylvania | 19107 | — |
| Carolina Eyecare Physicians | Mt. Pleasant | South Carolina | 29464 | — |
| Charles Retina Institute | Germantown | Tennessee | 38138 | — |
| Southeastern Retina Associates | Knoxville | Tennessee | 37922 | — |
| Tennessee Retina PC. | Nashville | Tennessee | 37203 | — |
| Austin Research Center for Retina | Austin | Texas | 78705 | — |
| Austin Clinical Research LLC | Austin | Texas | 78750 | — |
| Retina Consultants of Texas | Bellaire | Texas | 77401 | — |
| Retina Consultants of Texas | Houston | Texas | 77030 | — |
| Retina Center of Texas | Southlake | Texas | 76092 | — |
| Piedmont Eye Center | Lynchburg | Virginia | 24502 | — |
| Spokane Eye Clinical Research | Spokane | Washington | 99204 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04567303, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 14, 2026 · Synced Oct 27, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04567303 live on ClinicalTrials.gov.