Basket Study of Tucatinib and Trastuzumab in Solid Tumors With HER2 Alterations
Public ClinicalTrials.gov record NCT04579380. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2 Basket Study of Tucatinib in Combination With Trastuzumab in Subjects With Previously Treated, Locally Advanced Unresectable or Metastatic Solid Tumors Driven by HER2 Alterations
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This trial studies how well tucatinib works for solid tumors that make either more HER2 or a different type of HER2 than usual (HER2 alterations) The solid tumors studied in this trial have either spread to other parts of the body (metastatic) or cannot be removed completely with surgery (unresectable). All participants will get both tucatinib and trastuzumab. People with hormone-receptor positive breast cancer will also get a drug called fulvestrant. The trial will also look at what side effects happen. A side effect is anything a drug does besides treating cancer.
Study identification
- NCT ID
- NCT04579380
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 217 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 11, 2021 (Actual)
- Primary completion
- Nov 1, 2023 (Actual)
- Completion
- Dec 31, 2026 (Estimated)
- Last update posted
- Aug 21, 2026
2021 – 2026
United States locations
- U.S. sites
- 76
- U.S. states
- 19
- U.S. cities
- 50
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| HonorHealth | Phoenix | Arizona | 85016 | — |
| HonorHealth | Tempe | Arizona | 85284 | — |
| The University of Arizona Cancer Center-North Campus | Tucson | Arizona | 85719 | — |
| City of Hope at Huntington Beach | Huntington Beach | California | 92648 | — |
| City of Hope at Irvine Sand Canyon | Irvine | California | 92618 | — |
| Koman Family Outpatient Pavilion | La Jolla | California | 92037 | — |
| UC San Diego Medical Center - La Jolla (Jacobs Medical Center / Thornton Pavilion) | La Jolla | California | 92037 | — |
| UC San Diego Moores Cancer Center- Investigational Drug Services | La Jolla | California | 92037 | — |
| UC San Diego Moores Cancer Center | La Jolla | California | 92037 | — |
| City of Hope at Long Beach Worsham | Long Beach | California | 90808 | — |
| City of Hope at Long Beach Elm | Long Beach | California | 90813 | — |
| City of Hope at Newport Beach Lido | Newport Beach | California | 92663 | — |
| City of Hope Torrance | Torrance | California | 90505 | — |
| Rocky Mountain Cancer Centers | Aurora | Colorado | 80012 | — |
| Rocky Mountain Cancer Centers | Boulder | Colorado | 80303 | — |
| Rocky Mountain Cancer Centers | Thornton | Colorado | 80260 | — |
| Moffitt Cancer Center | Tampa | Florida | 33612 | — |
| Minnesota Oncology Hematology, PA | Coon Rapids | Minnesota | 55433 | — |
| Drug Storage and Regulatory location: MMCORC | Saint Louis Park | Minnesota | 55426 | — |
| Metro Minnesota Community Oncology Research Consortium (MMCORC) | Saint Louis Park | Minnesota | 55426 | — |
| Washington University School of Medicine - Obstetrics & Gynecology [Academic Offices) | St Louis | Missouri | 63108 | — |
| Barnes-Jewish Hospital Investigational Drug Pharmacy (IDS) | St Louis | Missouri | 63110 | — |
| Washington University School of Medicine - Obstetrics & Gynecology | St Louis | Missouri | 63110 | — |
| Washington University School of Medicine [Patient Clinics] | St Louis | Missouri | 63110 | — |
| Oncology Hematology West P.C. dba Nebraska Cancer Specialists | Omaha | Nebraska | 68114 | — |
| Oncology Hematology West P.C. dba Nebraska Cancer Specialists | Omaha | Nebraska | 68130 | — |
| NYU Langone Health - Long Island (Winthrop Hospital) | Mineola | New York | 11501 | — |
| Perlmutter Cancer Center at NYU Langone GYN Oncology Associates | Mineola | New York | 11501 | — |
| Perlmutter Cancer Center at NYU Langone Hospital - Long Island | Mineola | New York | 11501 | — |
| Laura and Isaac Perlmutter Cancer Center at NYU Langone | New York | New York | 10016 | — |
| NYU Langone Medical Center | New York | New York | 10016 | — |
| Icahn School of Medicine at Mount Sinai | New York | New York | 10029 | — |
| Duke University Medical Center/Duke Cancer Center | Durham | North Carolina | 27710 | — |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44106 | — |
| OSU Wexner Medical Center, CarePoint East | Columbus | Ohio | 43203 | — |
| OSU Wexner Medical Center, Ohio State University Hospital East | Columbus | Ohio | 43203 | — |
| OSU Wexner Medical Center, Arther G. James Cancer Hospital, and Solove Research Institute | Columbus | Ohio | 43210 | — |
| OSU Wexner Medical Center, Investigational Drug Services(IP Ship to) | Columbus | Ohio | 43210 | — |
| Osu Wexner Medical Center, The Ohio State University Hospital | Columbus | Ohio | 43210 | — |
| OSU Wexner Medical Center, Stephanie Spielman Comprehensive Breast Center | Columbus | Ohio | 43212 | — |
| OSU Wexner Medical Center, Martha Morehouse Medical Plaza | Columbus | Ohio | 43221 | — |
| OSU Wexner Medical Center, OutPatient Care Upper Arlington | Columbus | Ohio | 43221 | — |
| OSU Wexner Medical Center, CarePoint Gahanna | Gahanna | Ohio | 43230 | — |
| OSU Wexner Medical Center, Gynecologic Oncology at Mill Run | Hilliard | Ohio | 43026 | — |
| OSU Wexner Medical Center, Outpatient Care Lewis Center | Lewis Center | Ohio | 43035 | — |
| UH Minoff Health Center at Chagrin Highlands | Orange | Ohio | 44122 | — |
| OSU Wexner Medical Center, Outpatient Care New Albany | Westerville | Ohio | 43081 | — |
| Northwest Cancer Specialists, P.C. | Portland | Oregon | 97213 | — |
| Northwest Cancer Specialists, P.C. | Portland | Oregon | 97227 | — |
| Northwest Cancer Specialists, P.C. | Tigard | Oregon | 97223 | — |
| UPMC Hillman Cancer Center - Washington | Washington | Pennsylvania | 15301 | — |
| Prisma Health Cancer Institute | Boiling Springs | South Carolina | 29316 | — |
| Prisma Health Cancer Institute | Easley | South Carolina | 29640 | — |
| Prisma Health Cancer Institute | Greenville | South Carolina | 29605 | — |
| Prisma Health Cancer Institute | Greenville | South Carolina | 29615 | — |
| Prisma Health Cancer Institute | Greer | South Carolina | 29650 | — |
| Prisma Health Cancer Institute | Seneca | South Carolina | 29672 | — |
| Tennessee Oncology, PLLC | Gallatin | Tennessee | 37066 | — |
| Tennessee Oncology, PLLC | Hendersonville | Tennessee | 37075 | — |
| Tennessee Oncology, PLLC | Nashville | Tennessee | 37203 | — |
| Tennessee Oncology, PLLC | Shelbyville | Tennessee | 37160 | — |
| Texas oncology-West Texas | Abilene | Texas | 79606 | — |
| US Oncology Investigational Product Center (IPC) | Irving | Texas | 75063 | — |
| US Oncology Investigational Products Center (IPC) | Irving | Texas | 75063 | — |
| US Oncology lnvestigational Products Center (IPC) | Irving | Texas | 75063 | — |
| Texas Oncology - Central South | Waco | Texas | 76712 | — |
| Huntsman Cancer Institute, University of Utah | Salt Lake City | Utah | 84112 | — |
| Virginia Cancer Specialists, PC | Alexandria | Virginia | 22304 | — |
| Virginia Cancer Specialists, PC | Arlington | Virginia | 22205 | — |
| Virginia Cancer Specialists, PC | Fairfax | Virginia | 22031 | — |
| Virginia Cancer Specialists, PC | Gainesville | Virginia | 20155 | — |
| Fred Hutchinson Cancer Center | Seattle | Washington | 98109 | — |
| University of Washington Medical Center | Seattle | Washington | 98195 | — |
| Northwest Cancer Specialists, P.C. | Vancouver | Washington | 98684 | — |
| 1 S Park St Medical Center | Madison | Wisconsin | 53715 | — |
| University of Wisconsin Clinical Science Center | Madison | Wisconsin | 53792 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 32 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04579380, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 21, 2026 · Synced Oct 17, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04579380 live on ClinicalTrials.gov.