Comparative Effectiveness Study of Spironolactone Versus Doxycycline for Acne
Public ClinicalTrials.gov record NCT04582383. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Double-Blind, Multi-Center Comparative Effectiveness Study of Spironolactone Versus Doxycycline Hyclate for the Treatment of Acne in Women
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Acne is common illness of adolescents and young adults which is associated with substantial morbidity. While topical treatments are often sufficient for mild acne, moderate to severe acne often requires treatment with systemic medications such as oral antibiotics, hormonal therapies such spironolactone, and isotretinoin. Sebum overproduction is fundamental to the pathogenesis of acne with associated disordered keratinization and subsequent microbial colonization and inflammation resulting in the clinical manifestations of acne. Given the influence of hormones on sebum production, therapies that address these underlying hormonal factors such as spironolactone and oral contraceptive pills represent an underutilized treatment option for women with acne and could help decrease the use of long-term oral antibiotics in this patient population. The purpose of this trial is to evaluate the comparative effectiveness of spironolactone versus doxycycline hyclate (tetracycline class antibiotic) for women with acne.
Study identification
- NCT ID
- NCT04582383
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 4
- Enrollment
- 350 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 16 Years to 40 Years
- Sex
- Female
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 29, 2022
- Primary completion
- Feb 13, 2026
- Completion
- Jul 30, 2027
- Last update posted
- Aug 24, 2026
2022 – 2027
United States locations
- U.S. sites
- 18
- U.S. states
- 10
- U.S. cities
- 16
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Johnson Dermatology | Fort Smith | Arkansas | 72916 | — |
| University of California San Francisco | San Francisco | California | 94115 | — |
| Cura Clinical Research | Sherman Oaks | California | 92866 | — |
| University of Miami | Miami | Florida | 33136 | — |
| New Horizon Research Center | Miami | Florida | 33165 | — |
| Dawes Fretzin Clinical Research Group | Indianapolis | Indiana | 46250 | — |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | — |
| New York University | New York | New York | 10016 | — |
| Northwell Health | North New Hyde Park | New York | 11042 | — |
| Dermatologists of Central States | Cincinnati | Ohio | 45242 | — |
| Ohio State University Medical Center | Columbus | Ohio | 43215 | — |
| Cyn3rgy Research | Gresham | Oregon | 97030 | — |
| Oregon Health and Science University | Portland | Oregon | 97239 | — |
| Children's Hospital of Philadelphia | Philadelphia | Pennsylvania | 19104 | — |
| University of Pennsylvania | Philadelphia | Pennsylvania | 45209 | — |
| Arlington Research Center | Arlington | Texas | 76011 | — |
| North Texas Center for Clinical Research | Frisco | Texas | 75034 | — |
| CCS Texas | Houston | Texas | 77004 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04582383, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 24, 2026 · Synced Sep 2, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04582383 live on ClinicalTrials.gov.