Endovascular Ablation of the Right Greater Splanchnic Nerve in Subjects Having HFpEF

ClinicalTrials.gov ID: NCT04592445

Public ClinicalTrials.gov record NCT04592445. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Apr 20, 2026, 7:29 AM EDT

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Official title

Endovascular Ablation of the Right Greater Splanchnic Nerve in Subjects Having Heart Failure With Preserved Ejection Fraction: Randomized Controlled Feasibility Trial - The Rebalance HF Study

Study identification

NCT ID: NCT04592445
Recruitment status: Recruiting
Study type: Interventional
Phase: Not applicable
Lead sponsor: Axon Therapies, Inc.; Industry
Enrollment: 150 participants

Conditions and interventions

Conditions

Heart Failure With Preserved Ejection Fraction (HFpEF

Interventions

Greater Splanchnic Nerve Ablation Device
Sham Control Device

Device

Eligibility (public fields only)

Age range: 40 Years and older
Sex: All
Healthy volunteers: Not listed

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Dec 17, 2020
Primary completion: Jan 9, 2028
Completion: Aug 9, 2029
Last update posted: Mar 12, 2026

2020 – 2029

United States locations

U.S. sites: 20
U.S. states: 14
U.S. cities: 17

Facility	City	State	ZIP	Site status
Cardiology PC	Birmingham	Alabama	35211	Completed
Arizona Cardiovascular Research Center	Phoenix	Arizona	85016	Active, not recruiting
Scripps Health	La Jolla	California	92037	Active, not recruiting
University of California, San Francisco	San Francisco	California	94143	Recruiting
Bluhm Cardiovascular Institute of Northwestern University	Chicago	Illinois	60611	Recruiting
University of Chicago Medical Center	Chicago	Illinois	60637	Recruiting
Prairie Education and Research Cooperative	Springfield	Illinois	62701	Active, not recruiting
Ascension St. Vincent - Cardiovascular Research Institute	Indianapolis	Indiana	46260	Completed
Cardiovascular Institute of the South	Houma	Louisiana	70360	Recruiting
Michigan Medicine, University of Michigan	Ann Arbor	Michigan	48109	Recruiting
Mayo Clinic	Rochester	Minnesota	55905	Recruiting
St. Louis Heart and Vascular	St Louis	Missouri	63136	Recruiting
Weill Cornell Medicine	New York	New York	10021	Recruiting
Icahn School of Medicine at Mount Sinai	New York	New York	10029	Active, not recruiting
Columbia University Medical Center	New York	New York	10032	Recruiting
Rochester General Hospital	Rochester	New York	14621	Recruiting
Duke University Medical Center	Durham	North Carolina	27710	Recruiting
Ohio State University Wexner Medical Center	Columbus	Ohio	43210	Recruiting
Medical University of South Carolina	Charleston	South Carolina	29425	Recruiting
Virginia Commonwealth University Medical Center	Richmond	Virginia	23298	Active, not recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT04592445, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Mar 12, 2026 · Synced Apr 20, 2026

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The complete protocol, eligibility criteria, and contact information for NCT04592445 live on ClinicalTrials.gov.

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