Study of PF-07248144 in Advanced or Metastatic Solid Tumors
Public ClinicalTrials.gov record NCT04606446. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A PHASE 1/2A DOSE ESCALATION AND EXPANSION STUDY TO EVALUATE SAFETY, TOLERABILITY, PHARMACOKINETIC, PHARMACODYNAMIC, AND ANTI-TUMOR ACTIVITY OF PF-07248144 IN PARTICIPANTS WITH ADVANCED OR METASTATIC SOLID TUMORS
Study identification
- NCT ID
- NCT04606446
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Pfizer
- Industry
- Enrollment
- 320 participants
Conditions and interventions
Conditions
Interventions
- Fulvestrant Drug
- Letrozole Drug
- PF-07220060 Drug
- PF-07248144 Drug
- PF-07850327, ARV-471, vepdegestrant Drug
- Palbociclib Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 15, 2020
- Primary completion
- Jul 12, 2029
- Completion
- Aug 9, 2029
- Last update posted
- Apr 15, 2026
2020 – 2029
United States locations
- U.S. sites
- 23
- U.S. states
- 8
- U.S. cities
- 14
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| HonorHealth | Scottsdale | Arizona | 85258 | Terminated |
| Cedars Sinai Medical Center | Los Angeles | California | 90048 | Recruiting |
| Cedars-Sinai Cancer at Cedars-Sinai Medical Center | Los Angeles | California | 90048 | Recruiting |
| UCSF Medical Center at Mission Bay | San Francisco | California | 94158 | Recruiting |
| Smilow Cancer Hospital at Yale - New Haven | New Haven | Connecticut | 06510 | Recruiting |
| Yale-New Haven Hospital- Yale Cancer Center | New Haven | Connecticut | 06510 | Recruiting |
| Smilow Cancer Hospital Phase 1 Unit | New Haven | Connecticut | 06511 | Recruiting |
| Yale University | New Haven | Connecticut | 06511 | Recruiting |
| Holy Cross Hospital | Fort Lauderdale | Florida | 33308 | Terminated |
| St. Elizabeth Healthcare | Edgewood | Kentucky | 41017 | Recruiting |
| University Medical Center, lnc.:DBA University of Louisville Hospital | Louisville | Kentucky | 40202 | Recruiting |
| University of Louisville | Louisville | Kentucky | 40202 | Recruiting |
| UofL Health Brown Cancer Center | Louisville | Kentucky | 40202 | Recruiting |
| SCRI Oncology Partners | Nashville | Tennessee | 37203 | Recruiting |
| MD Anderson The Woodlands | Conroe | Texas | 77384 | Recruiting |
| The University of Texas M. D. Anderson Cancer Center | Houston | Texas | 77030 | Recruiting |
| U.T. MD Anderson Cancer Center | Houston | Texas | 77030 | Recruiting |
| MD Anderson West Houston | Houston | Texas | 77079 | Recruiting |
| MD Anderson League City | League City | Texas | 77573 | Recruiting |
| NEXT Oncology | San Antonio | Texas | 78229 | Recruiting |
| MD Anderson | Sugar Land | Texas | 77478 | Recruiting |
| Swedish Cancer Institute | Seattle | Washington | 98104 | Recruiting |
| Swedish Medical Center | Seattle | Washington | 98122 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 21 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04606446, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 15, 2026 · Synced May 5, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04606446 live on ClinicalTrials.gov.