ClinicalTrials.gov record
A Study of Encorafenib Plus Cetuximab With or Without Chemotherapy in People With Previously Untreated Metastatic Colorectal Cancer
ClinicalTrials.gov ID: NCT04607421
Public ClinicalTrials.gov record NCT04607421. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced Apr 27, 2026, 7:25 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
AN OPEN-LABEL, MULTICENTER, RANDOMIZED PHASE 3 STUDY OF FIRST-LINE ENCORAFENIB PLUS CETUXIMAB WITH OR WITHOUT CHEMOTHERAPY VERSUS STANDARD OF CARE THERAPY WITH A SAFETY LEAD-IN OF ENCORAFENIB AND CETUXIMAB PLUS CHEMOTHERAPY IN PARTICIPANTS WITH METASTATIC BRAF V600E-MUTANT COLORECTAL CANCER
Study identification
- NCT ID
- NCT04607421
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Pfizer
- Industry
- Enrollment
- 831 participants
Conditions and interventions
Conditions
Interventions
- 5-FU Drug
- Bevacizumab Drug
- Capecitabine Drug
- Cetuximab Drug
- Encorafenib Drug
- Irinotecan Drug
- Leucovorin Drug
- Oxaliplatin Drug
Drug
Eligibility (public fields only)
- Age range
- 16 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 20, 2020
- Primary completion
- Dec 7, 2025
- Completion
- Dec 27, 2027
- Last update posted
- Aug 13, 2025
2020 – 2027
United States locations
- U.S. sites
- 62
- U.S. states
- 19
- U.S. cities
- 41
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Mayo Clinic Hospital | Phoenix | Arizona | 85054 | — |
| Mayo Clinic in Arizona - Scottsdale | Scottsdale | Arizona | 85259 | — |
| Keck Hospital of USC | Los Angeles | California | 90033 | — |
| LAC & USC Medical Center | Los Angeles | California | 90033 | — |
| USC / Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | — |
| USC/Norris Comprehensive Cancer Center/Investigational Drug Services | Los Angeles | California | 90033 | — |
| USC/Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | — |
| Keck Hospital of USC Pasadena | Pasadena | California | 91105 | — |
| Mount Sinai Comprehensive Cancer Center, Aventura | Aventura | Florida | 33180 | — |
| Mount Sinai Comprehensive Cancer Center | Miami Beach | Florida | 33140 | — |
| Mount Sinai Medical Center | Miami Beach | Florida | 33140 | — |
| BRCR Global | Plantation | Florida | 33322 | — |
| BRCR Medical Center Inc. | Plantation | Florida | 33322 | — |
| UChicago Medicine - River East | Chicago | Illinois | 60611 | — |
| University of Chicago Medical Center | Chicago | Illinois | 60637 | — |
| UChicago Medicine at Ingalls - Flossmoor | Flossmoor | Illinois | 60422 | — |
| UChicago Medicine Ingalls Memorial | Harvey | Illinois | 60426 | — |
| University of Chicago Comprehensive Cancer Center at Silver Cross Hospital | New Lenox | Illinois | 60451 | — |
| The University of Chicago Medicine Center for Advanced Care Orland Park | Orland Park | Illinois | 60462 | — |
| UChicago Medicine at Ingalls - Tinley Park | Tinley Park | Illinois | 60477 | — |
| Ochsner Clinic Foundation | New Orleans | Louisiana | 70121 | — |
| Mayo Clinic Rochester | Rochester | Minnesota | 55905 | — |
| Siteman Cancer Center - St Peters | City of Saint Peters | Missouri | 63376 | — |
| Siteman Cancer Center - West County | Creve Coeur | Missouri | 63141 | — |
| Siteman Cancer Center - North County | Florissant | Missouri | 63031 | — |
| Barnes- Jewish Hospital | St Louis | Missouri | 63110 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Siteman Cancer Center - South County | St Louis | Missouri | 63129 | — |
| Oncology Hematology West PC dba Nebraska Cancer Specialists | Omaha | Nebraska | 68114 | — |
| Oncology Hematology West PC dba Nebraska Cancer Specialists | Omaha | Nebraska | 68124 | — |
| Oncology Hematology West PC dba Nebraska Cancer Specialists | Omaha | Nebraska | 68130 | — |
| Oncology Hematology West PC dba Nebraska Cancer Specialists | Papillion | Nebraska | 68046 | — |
| Memorial Sloan Kettering Cancer Center - Basking Ridge | Basking Ridge | New Jersey | 07920 | — |
| Summit Medical Group | Berkeley Heights | New Jersey | 07922 | — |
| Summit Medical Group | Florham Park | New Jersey | 07932 | — |
| Memorial Sloan Kettering Cancer Center- Monmouth | Middletown | New Jersey | 07748 | — |
| Memorial Sloan Kettering Cancer Center- Bergen | Montvale | New Jersey | 07645 | — |
| Memorial Sloan Kettering Cancer Center Commack | Commack | New York | 11725 | — |
| Memorial Sloan Kettering Cancer Center - Westchester | Harrison | New York | 10604 | — |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10022 | — |
| Memorial Sloan Kettering Cancer Center - Main Campus | New York | New York | 10065 | — |
| Memorial Sloan Kettering Cancer Center- Nassau | Uniondale | New York | 11553 | — |
| Cleveland Clinic Taussig Cancer Center Investigational Pharmacy | Cleveland | Ohio | 44195 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| The Ohio State University James Cancer Hospital and Solove Research Institute | Columbus | Ohio | 43210 | — |
| Stefanie Spielman Comprehensive Breast Cancer | Columbus | Ohio | 43212 | — |
| Martha Morehouse Medical Plaza | Columbus | Ohio | 43221 | — |
| The James Outpatient Care West Campus | Columbus | Ohio | 43221 | — |
| University of Oklahoma Health Sciences Center, OU Health Stephenson Cancer Center | Oklahoma City | Oklahoma | 73104 | — |
| Providence Cancer Institute Franz Clinic | Portland | Oregon | 97213 | — |
| Providence Portland Medical Center | Portland | Oregon | 97213 | — |
| Providence Onc and Heme Care Clinic - Westside | Portland | Oregon | 97225 | — |
| Providence St Vincent Medical Center | Portland | Oregon | 97225 | — |
| UPMC Hillman Cancer Center | Pittsburgh | Pennsylvania | 15232 | — |
| The West Clinic. PLLC. dba West Cancer Center | Germantown | Tennessee | 38138 | — |
| Henry-Joyce Cancer Center | Nashville | Tennessee | 37232 | — |
| Vanderbilt-Ingram Cancer Center | Nashville | Tennessee | 37232 | — |
| The University of Texas MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| Virginia Commonwealth University | Richmond | Virginia | 23219 | — |
| Seattle Cancer Care Alliance | Seattle | Washington | 98109 | — |
| University of Washington Medical Center | Seattle | Washington | 98195 | — |
| University of Wisconsin Clinical Science Center | Madison | Wisconsin | 53792 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 206 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04607421, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 13, 2025 · Synced Apr 27, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04607421 live on ClinicalTrials.gov.