Trilaciclib, a CDK 4/6 Inhibitor, in Patients Receiving FOLFOXIRI/Bevacizumab for Metastatic Colorectal Cancer (mCRC):
Public ClinicalTrials.gov record NCT04607668. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
PRESERVE 1: A Phase 3 Randomized, Double-blind Trial of Trilaciclib Versus Placebo in Patients Receiving FOLFOXIRI/Bevacizumab for Metastatic Colorectal Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This was a randomized, double-blind, placebo-controlled, global, multicenter, Phase 3 trial evaluating the impact of trilaciclib on myelopreservation and anti-tumor efficacy when administered prior to FOLFOXIRI/bevacizumab in patients with pMMR/MSS mCRC who have not received systemic therapy for metastatic disease.
Study identification
- NCT ID
- NCT04607668
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 326 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 6, 2021 (Actual)
- Primary completion
- Feb 13, 2023 (Actual)
- Completion
- Mar 31, 2023 (Actual)
- Last update posted
- Nov 26, 2024
2021 – 2023
United States locations
- U.S. sites
- 24
- U.S. states
- 15
- U.S. cities
- 23
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| AZ Oncology Associates - HOPE | Tucson | Arizona | 85711 | — |
| Beverly Hills Cancer Center | Beverly Hills | California | 90211 | — |
| Keck Medical Center of USC Pasadena | Los Angeles | California | 90033 | — |
| The Oncology Institute of Hope & Innovation\ Innovative Clinical Research Institute | Whittier | California | 90603 | — |
| Georgetown University - Lombardi Comprehensive Cancer Center | Washington D.C. | District of Columbia | 20007 | — |
| Florida Cancer Specialists (South Region) | Fort Myers | Florida | 33916 | — |
| Florida Cancer Specialists NORTH | Fort Myers | Florida | 33916 | — |
| Mid-Florida Hematology & Oncology Centers, P.A. | Orange City | Florida | 32763 | — |
| Florida Cancer Specialists | St. Petersburg | Florida | 33705 | — |
| Florida Cancer Specialists - Panhandle | Tallahassee | Florida | 32308 | — |
| Northside Hospital - Georgia Cancer Specialists | Atlanta | Georgia | 30342 | — |
| Illinois Cancer Specialists | Arlington Heights | Illinois | 60005 | — |
| Boston Medical Center | Boston | Massachusetts | 02118 | — |
| University of Massachusetts Memorial Medical Center | Worcester | Massachusetts | 01655 | — |
| Mayo Clinic - Rochester | Rochester | Minnesota | 55905 | — |
| Comp. Cancer Centers of Nevada | Las Vegas | Nevada | 89169 | — |
| University of Oklahoma Health Sciences Center | Oklahoma City | Oklahoma | 73104 | — |
| Oregon Health & Science University | Portland | Oregon | 97239 | — |
| Gettysburg Cancer Center | Gettysburg | Pennsylvania | 17325 | — |
| Tennessee Oncology | Nashville | Tennessee | 37203 | — |
| UT Southwestern Medical Center | Dallas | Texas | 75390 | — |
| Millennium Oncology | Kingswood | Texas | 77339 | — |
| Inova Schar Cancer Institute | Fairfax | Virginia | 22031 | — |
| Onc and Hem Assoc of SW VA | Roanoke | Virginia | 24014 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 58 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04607668, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 26, 2024 · Synced Oct 22, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04607668 live on ClinicalTrials.gov.