A Study of Avutometinib (VS-6766) + Defactinib in Recurrent KRAS G12V, Other KRAS and BRAF Non-Small Cell Lung Cancer
Public ClinicalTrials.gov record NCT04620330. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2 Study of Avutometinib (VS-6766) (Dual RAF/MEK Inhibitor) as a Single Agent and In Combination With Defactinib (FAK Inhibitor) in Recurrent KRAS-Mutant (KRAS-MT) and BRAF-Mutant (BRAF-MT) Non-Small Cell Lung Cancer (NSCLC) (RAMP 202)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will assess the safety and efficacy of avutometinib (VS-6766) monotherapy or VS-6766 in combination with defactinib in subjects with recurrent Non-small cell lung cancer.
Study identification
- NCT ID
- NCT04620330
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 90 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 31, 2020 (Actual)
- Primary completion
- Aug 29, 2023 (Actual)
- Completion
- Dec 12, 2023 (Actual)
- Last update posted
- Jan 12, 2024
2020 – 2023
United States locations
- U.S. sites
- 28
- U.S. states
- 19
- U.S. cities
- 27
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| City of Hope | Duarte | California | 91010 | — |
| University of Colorado Hospital | Aurora | Colorado | 80045 | — |
| Rocky Mountain Cancer Centers | Lone Tree | Colorado | 80124 | — |
| Georgetown University Medical Center | Washington D.C. | District of Columbia | 20007 | — |
| Florida Cancer Specialists | Fort Myers | Florida | 33908 | — |
| Florida Cancer Specialists | St. Petersburg | Florida | 33705 | — |
| Emory University School of Medicine | Atlanta | Georgia | 30322 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| University of Chicago Medical Center-Duchossois Center for Advanced Medicine | Chicago | Illinois | 60637 | — |
| Illinois Cancer Specialists | Niles | Illinois | 60714 | — |
| Hematology/Oncology Clinic, LLP | Baton Rouge | Louisiana | 70809 | — |
| Maryland Oncology Hematology P.A | Columbia | Maryland | 21044 | — |
| Dana Farber Cancer Institute | Boston | Massachusetts | 02215 | — |
| Henry Ford Cancer Institute/Henry Ford Health System | Detroit | Michigan | 48202 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601 | — |
| Northwell Health-Monter Cancer Center | Lake Success | New York | 11042 | — |
| Zangmeister Cancer Center | Columbus | Ohio | 43219 | — |
| Northwest Cancer Specialists, P.C. | Portland | Oregon | 97213 | — |
| Fox Chase Cancer Center | Philadelphia | Pennsylvania | 19111 | — |
| Univ. of Pittsburgh Med Center | Pittsburgh | Pennsylvania | 15232 | — |
| Chattanooga Oncology Hematology Assoc. | Chattanooga | Tennessee | 037404 | — |
| Tennessee Oncology | Nashville | Tennessee | 37203 | — |
| Texas Oncology | Dallas | Texas | 75246 | — |
| Texas Oncology Ft Worth Cancer Center | Fort Worth | Texas | 76104 | — |
| Texas Oncology | Grapevine | Texas | 76051 | — |
| MD Anderson Cancer Center | Houston | Texas | 77030 | — |
| Virginia Cancer Specialists, PC | Fairfax | Virginia | 22031 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 17 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04620330, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 12, 2024 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04620330 live on ClinicalTrials.gov.