A Study of Etavopivat in Adults and Adolescents With Sickle Cell Disease (HIBISCUS)
Public ClinicalTrials.gov record NCT04624659. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
An Adaptive, Randomized, Placebo-controlled, Double-blind, Multi-center Study of Oral Etavopivat, a Pyruvate Kinase Activator in Patients With Sickle Cell Disease (HIBISCUS)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This clinical trial is a Phase 2/3 study that will evaluate the efficacy and safety of etavopivat and test how well etavopivat works compared to placebo to improve the amount of hemoglobin in the blood and to reduce the number of vaso-occlusive crises (times when the blood vessels become blocked and cause pain).
Study identification
- NCT ID
- NCT04624659
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 450 participants
Conditions and interventions
Conditions
Interventions
- Etavopivat Tablets Low dose Drug
- Etavopivat Tablets High dose Drug
- Placebo Tablets Drug
- Etavopivat Tablets Drug
Drug
Eligibility (public fields only)
- Age range
- 12 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 29, 2021 (Actual)
- Primary completion
- Feb 6, 2026 (Actual)
- Completion
- Mar 19, 2027 (Estimated)
- Last update posted
- Apr 6, 2026
2021 – 2027
United States locations
- U.S. sites
- 63
- U.S. states
- 27
- U.S. cities
- 50
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Univ of Alabama Birmingham | Birmingham | Alabama | 35233 | — |
| Phoenix Children's Hsptl | Phoenix | Arizona | 85016 | — |
| [Legal] Woodland International Research Group, LLC | Little Rock | Arkansas | 72211 | — |
| [Legal] Collaborative Neuroscience Network, LLC | Long Beach | California | 90806 | — |
| Pacific Research Partners | Oakland | California | 94607 | — |
| UCSF Oakland Benioff ChildHosp | Oakland | California | 94609 | — |
| University Of California Irvine | Orange | California | 92868 | — |
| UC Davis Medical Center | Sacramento | California | 95817 | — |
| University of Connecticut | Farmington | Connecticut | 06030 | — |
| Yale University | New Haven | Connecticut | 06519 | — |
| Children's National Health Hospital | Washington D.C. | District of Columbia | 20010 | — |
| Howard University | Washington D.C. | District of Columbia | 20060 | — |
| Cornerstone Research Institute | Altamonte Springs | Florida | 32701 | — |
| University of Florida | Gainesville | Florida | 32610 | — |
| Foundation for Sickle Cell Disease Research | Hollywood | Florida | 33023 | — |
| University Of Miami | Miami | Florida | 33136 | — |
| Advanced Pharma CR | Miami | Florida | 33147 | — |
| Arnold Palmer Children's Hospital | Orlando | Florida | 32806 | — |
| Emory University School of Medicine | Atlanta | Georgia | 30303 | — |
| Sonar Clinical Research | Atlanta | Georgia | 30315 | — |
| Children's Healthcare of Atlanta Investigational Medication Pharmacy | Atlanta | Georgia | 30342 | — |
| Center for Blood Disorders Augusta University | Augusta | Georgia | 30912 | — |
| iResearch Atlanta, LLC | Decatur | Georgia | 30030 | — |
| University of Illinois at Chicago | Chicago | Illinois | 60612 | — |
| Children's Hosp-New Orleans | New Orleans | Louisiana | 70118 | — |
| University Of Maryland School of Medicine | Baltimore | Maryland | 21201 | — |
| Massachusetts General Hospital_Boston | Boston | Massachusetts | 02114 | — |
| Boston Medical Center | Boston | Massachusetts | 02118 | — |
| [Legal] Dr. Vince Clinical Research, LLC and Dr. Vince Clinical Research, P.A. | Detroit | Michigan | 48201 | — |
| Karmanos Cancer Institute | Detroit | Michigan | 48201 | — |
| Washington University School of Medicine_St. Louis | St Louis | Missouri | 63110 | — |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198-2168 | — |
| NYC Health+Hospitals | Brooklyn | New York | 11203 | — |
| Queens Hospital Center | Jamaica | New York | 11432-1121 | — |
| North Shore Long Island Jewish Medical Center | New Hyde Park | New York | 11040 | — |
| Columbia University Medical Center_New York | New York | New York | 10032 | — |
| Weill Cornell Med Coll-NYPH | New York | New York | 10065 | — |
| Jacobi Medical Center | The Bronx | New York | 10461 | — |
| Montefiore Medical Center | The Bronx | New York | 10467 | — |
| [Legal] The University of North Carolina at Chapel Hill | Chapel Hill | North Carolina | 27514 | — |
| Levine Cancer Institute | Charlotte | North Carolina | 28204 | — |
| Duke University Medical Center | Durham | North Carolina | 27710 | — |
| East Carolina University | Greenville | North Carolina | 27858 | — |
| Wake Forest Baptist Health | Winston-Salem | North Carolina | 27157 | — |
| University of Cincinnati | Cincinnati | Ohio | 45219 | — |
| [Legal] Children's Hospital Medical Center dba Cincinnati Children's | Cincinnati | Ohio | 45229 | — |
| The Ohio State University Medical Center | Columbus | Ohio | 43203 | — |
| Neuro-Behavioral Clinical Research | North Canton | Ohio | 44720 | — |
| Jimmy Everest Cancer Hematology & Oncology | Oklahoma City | Oklahoma | 73104 | — |
| Lynn Institute of Tulsa | Tulsa | Oklahoma | 74135 | — |
| Children's Hosptl Philadelphia | Philadelphia | Pennsylvania | 19104 | — |
| Thomas Jefferson University Hospital | Philadelphia | Pennsylvania | 19107 | — |
| University of Pittsburgh Medical Center | Pittsburgh | Pennsylvania | 15213-4306 | — |
| Rhode Island Hospital | Providence | Rhode Island | 02903 | — |
| Medical University of South Carolina | Charleston | South Carolina | 29425 | — |
| Prisma Health-Upstate | Greenville | South Carolina | 29605 | — |
| Methodist University Hospital | Memphis | Tennessee | 38104 | — |
| [Legal] St. Jude Children's Research Hospital | Memphis | Tennessee | 38105 | — |
| [Legal] Baylor College of Medicine | Houston | Texas | 77030 | — |
| UT Health University of Texas | Houston | Texas | 77030 | — |
| Virginia Commonwealth University | Richmond | Virginia | 23298 | — |
| Mary Bridge Children's Health | Tacoma | Washington | 98405 | — |
| Versiti Blood Center of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 79 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04624659, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 6, 2026 · Synced Oct 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04624659 live on ClinicalTrials.gov.