CRISPR-Edited Allogeneic Anti-CD19 CAR-T Cell Therapy for Relapsed/Refractory B Cell Non-Hodgkin Lymphoma (ANTLER)
Public ClinicalTrials.gov record NCT04637763. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 1, Multicenter, Open-Label Study of CB-010, a CRISPR-Edited Allogeneic Anti-CD19 CAR-T Cell Therapy in Patients With Relapsed/Refractory B Cell Non-Hodgkin Lymphoma (ANTLER)
Study identification
- NCT ID
- NCT04637763
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 1
- Lead sponsor
- Caribou Biosciences, Inc.
- Industry
- Enrollment
- 72 participants
Conditions and interventions
Conditions
Interventions
- CB-010 Genetic
- Cyclophosphamide Drug
- Fludarabine Drug
Genetic · Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Not listed
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 25, 2021
- Primary completion
- Jul 31, 2025
- Completion
- Aug 31, 2025
- Last update posted
- Mar 23, 2025
2021 – 2025
United States locations
- U.S. sites
- 31
- U.S. states
- 20
- U.S. cities
- 31
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35233 | Terminated |
| Banner MD Anderson Cancer Center | Gilbert | Arizona | 85234 | Recruiting |
| HonorHealth | Scottsdale | Arizona | 85258 | Recruiting |
| University of Arizona Cancer Center | Tucson | Arizona | 85724 | Recruiting |
| University of Arkansas | Little Rock | Arkansas | 72205 | Recruiting |
| University of California San Diego Moores Cancer Center | La Jolla | California | 92073 | Recruiting |
| University of Southern California, Norris Comprehensive Cancer Center | Los Angeles | California | 90089 | Recruiting |
| Chao Family Comprehensive Cancer Center/University of California Irvine | Orange | California | 92868 | Recruiting |
| Advent Health | Orlando | Florida | 32803 | Recruiting |
| Bone and Marrow Transplant Group of Georgia | Atlanta | Georgia | 30342 | Recruiting |
| Georgia Cancer Center at Augusta University | Augusta | Georgia | 30912 | Recruiting |
| Holden Comprehensive Cancer Center at the University of Iowa | Iowa City | Iowa | 52242 | Recruiting |
| University of Kentucky Markey Cancer | Lexington | Kentucky | 40536 | Recruiting |
| Norton Cancer Institute | Louisville | Kentucky | 40207 | Recruiting |
| Tufts Medical Center | Boston | Massachusetts | 02111 | Recruiting |
| Hackensack Medical Center | Hackensack | New Jersey | 07601 | Recruiting |
| Atlantic Health System | Morristown | New Jersey | 07960 | Recruiting |
| Nyu Langone Health | New York | New York | 10016 | Recruiting |
| Montefiore Medical Center | The Bronx | New York | 10461 | Recruiting |
| Oncology Hematology Care | Cincinnati | Ohio | 45242 | Recruiting |
| Ohio State University James Cancer Hospital | Columbus | Ohio | 43210 | Terminated |
| Oregon Health & Science University | Portland | Oregon | 97239 | Recruiting |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | Recruiting |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37323 | Recruiting |
| Baylor Charles A. Sammons Cancer Center | Dallas | Texas | 75246 | Recruiting |
| MD Anderson Cancer Center | Houston | Texas | 77030-4009 | Recruiting |
| Huntsman Cancer Institute at the University of Utah | Salt Lake City | Utah | 84112 | Recruiting |
| Virginia Oncology Associates | Norfolk | Virginia | 23502 | Recruiting |
| Virginia Commonwealth University (VCU) | Richmond | Virginia | 23219 | Recruiting |
| Swedish Cancer Institute | Seattle | Washington | 98104 | Terminated |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 7 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04637763, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 23, 2025 · Synced Apr 22, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04637763 live on ClinicalTrials.gov.