Study Evaluating mCRPC Treatment Using PSMA [Lu-177]-PNT2002 Therapy After Second-line Hormonal Treatment
Public ClinicalTrials.gov record NCT04647526. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Open-Label, Randomized Study Evaluating Metastatic Castrate Resistant Prostate Cancer Treatment Using PSMA [Lu-177]-PNT2002 Therapy After Second-line Hormonal Treatment (SPLASH)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate the efficacy and safety of \[Lu-177\]-PNT2002 in patients with metastatic castration-resistant prostate cancer who have progressed following treatment with androgen receptor axis-targeted therapy (ARAT).
Study identification
- NCT ID
- NCT04647526
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 455 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Male
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 25, 2021 (Actual)
- Primary completion
- Nov 1, 2023 (Actual)
- Completion
- Mar 2028 (Estimated)
- Last update posted
- Jan 13, 2026
2021 – 2028
United States locations
- U.S. sites
- 33
- U.S. states
- 20
- U.S. cities
- 27
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Arizona Institute of Urology (AIU) - Tucson | Tucson | Arizona | 85704 | — |
| Cedars-Sinai Medical Center, Samuel Oschin Comprehensive Cancer Institute | Los Angeles | California | 90048 | — |
| VA Greater Los Angeles Healthcare System | Los Angeles | California | 90073 | — |
| University of California Los Angeles, Nuclear Medicine Clinic | Los Angeles | California | 90095 | — |
| Hoag Memorial Hospital Presbyterian | Newport Beach | California | 92663 | — |
| UC Irvine Chao Family Comprehensive Cancer Center | Orange | California | 92868 | — |
| Stanford Cancer Institute | Palo Alto | California | 94305 | — |
| University of Colorado Hospital | Aurora | Colorado | 80045 | — |
| H. Lee Moffitt Cancer Center & Research Institute | Tampa | Florida | 33612 | — |
| University of Iowa Hospitals and Clinics | Iowa City | Iowa | 52242 | — |
| University of Kentucky Chandler Medical Center | Lexington | Kentucky | 40536 | — |
| Tulane University Medical Center | New Orleans | Louisiana | 70112 | — |
| University of Maryland Greenebaum Cancer Center | Baltimore | Maryland | 21201 | — |
| Chesapeake Urology Associates (CUA) P.A. | Towson | Maryland | 21204 | — |
| University of Michigan Hospitals | Ann Arbor | Michigan | 48109 | — |
| Karmanos Cancer Center | Detroit | Michigan | 48201 | — |
| VA St. Louis Health Care System | St Louis | Missouri | 63106 | — |
| Saint Louis University Hospital | St Louis | Missouri | 63110 | — |
| Washington University School of Medicine | St Louis | Missouri | 63110 | — |
| Urology Cancer Center, PC | Omaha | Nebraska | 68130 | — |
| Astera Cancer Care | East Brunswick | New Jersey | 08816 | — |
| New Mexico Oncology Hematology Consultants Ltd., New Mexico Cancer Center | Albuquerque | New Mexico | 87109 | — |
| New York Presbyterian Hospital/Weill Cornell Medical Center | New York | New York | 10065 | — |
| Tri-State Urologic Services | Cincinnati | Ohio | 45212 | — |
| Greater Dayton Cancer Center | Kettering | Ohio | 45409 | — |
| Perelman Center for Advanced Medicine | Philadelphia | Pennsylvania | 19104 | — |
| Fox Chase Cancer Center | Philadelphia | Pennsylvania | 19111 | — |
| Carolina Urologic Research Center | Myrtle Beach | South Carolina | 29572 | — |
| Vanderbilt-Ingram Cancer Center | Nashville | Tennessee | 37232 | — |
| Dallas VA Medical Center, Nuclear Medicine Service | Dallas | Texas | 75216 | — |
| UT Southwestern Medical Center | Dallas | Texas | 75390 | — |
| Excel Diagnostics & Nuclear Oncology Center | Houston | Texas | 77402 | — |
| Swedish Cancer Institute Research | Seattle | Washington | 98104 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 21 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04647526, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 13, 2026 · Synced Oct 19, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04647526 live on ClinicalTrials.gov.