Randomized Study in Children and Adolescents With Migraine: Acute Treatment

ClinicalTrials.gov ID: NCT04649242

Public ClinicalTrials.gov record NCT04649242. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 20, 2026, 1:19 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Phase 3, Multicenter, Randomized, Double-blind, Group Sequential, Placebo-controlled Study to Assess Efficacy and Safety of Rimegepant for the Treatment of Migraine (With or Without Aura) in Children and Adolescents ≥ 6 to < 18 Years of Age

Study identification

NCT ID: NCT04649242
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Pfizer; Industry
Enrollment: 2,100 participants

Conditions and interventions

Conditions

Pediatric Migraine

Interventions

Matching placebo Drug
Rimegepant/BHV3000 Drug

Drug

Eligibility (public fields only)

Age range: 6 Years to 17 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jan 14, 2021
Primary completion: Jan 8, 2029
Completion: Jan 8, 2029
Last update posted: May 19, 2026

2021 – 2029

United States locations

U.S. sites: 171
U.S. states: 38
U.S. cities: 110

Facility	City	State	ZIP	Site status
Achieve Clinical Research, LLC d/b/a Accel Research Sites-Neurology and Neurodiagnostic of Alabama	Birmingham	Alabama	35244	Active, not recruiting
Perseverance Research Center, LLC	Scottsdale	Arizona	85253	Recruiting
Physicians Research Group	Tempe	Arizona	85284	Active, not recruiting
Advanced Research Center, Inc.	Anaheim	California	92805	Recruiting
Adult & Child Neurology Medical Associates	Costa Mesa	California	92627	Recruiting
ProScience Research Group	Culver City	California	90230	Active, not recruiting
Memorial Health Services	Fountain Valley	California	92708	Recruiting
Neuro-Pain Research Center	Fresno	California	93710	Recruiting
Regents of the University of California (UC San Diego)	La Jolla	California	92093	Recruiting
Adult & Child Neurology Medical Associates	Long Beach	California	90806	Recruiting
Miller Children's & Women's Hospital Long Beach	Long Beach	California	90806	Recruiting
National Research Institute	Los Angeles	California	90057	Active, not recruiting
Velocity Clinical Research - North Hollywood	North Hollywood	California	91606	Active, not recruiting
Children's Hospital of Orange County - Inpatient Pharmacy	Orange	California	92868	Not yet recruiting
Children's Hospital of Orange County - Neuroscience Center	Orange	California	92868	Not yet recruiting
Children's Hospital of Orange County	Orange	California	92868	Not yet recruiting
The Neurology Group	Pomona	California	91767	Recruiting
University of California, Davis Midtown Clinic	Sacramento	California	95816	Active, not recruiting
UC Davis Medical Center, Investigational Drug Service (IDS) Pharmacy	Sacramento	California	95817	Active, not recruiting
University of California, Davis Clinical and Translational Science Center Clinical Research (CCRC)	Sacramento	California	95817	Active, not recruiting
Velocity Clinical Research, San Bernardino (IP Delivery and Administering Location)	San Bernardino	California	92408	Recruiting
Pacific Clinical Research Management Group LLC	Upland	California	91786	Active, not recruiting
Sunwise Clinical Research	Walnut Creek	California	94596	Recruiting
Children's Hospital Colorado- lnvestigational Drug Services	Aurora	Colorado	80045	Recruiting
Children's Hospital Colorado	Aurora	Colorado	80045	Recruiting
Colorado Springs Neurological Associates, PC	Colorado Springs	Colorado	80907	Active, not recruiting
Colorado Springs Neurological Associates, PC	Colorado Springs	Colorado	80919	Active, not recruiting
CT Clinical Research	Cromwell	Connecticut	06416	Recruiting
Connecticut Children's Medical Center	Hartford	Connecticut	06106	Active, not recruiting
Ki Health Partners, LLc, dba New England Institute for Clinical Research	Stamford	Connecticut	06905	Recruiting
Nemours Children's Hospital, Delaware	Wilmington	Delaware	19803	Active, not recruiting
Children's National Medical Center	Washington D.C.	District of Columbia	20010	Recruiting
Topaz Clinical Research, Inc.	Apopka	Florida	32703	Active, not recruiting
Beautiful Minds Clinical Research Center	Cutler Bay	Florida	33157	Terminated
DeLand Clinical Research Unit	DeLand	Florida	32720	Terminated
Sarkis Clinical Trials	Gainesville	Florida	32607	Active, not recruiting
Multi-Specialty Research Associates, Inc.	Lake City	Florida	32055	Active, not recruiting
Watson Clinic Center for Research, Inc.	Lakeland	Florida	33805	Terminated
Watson Clinic LLP	Lakeland	Florida	33805	Terminated
AppleMed Research Group, LLC	Miami	Florida	33126	Active, not recruiting
Medical Research Center of Miami II, Inc	Miami	Florida	33134	Active, not recruiting
South Florida Research Phase I-IV, Inc	Miami	Florida	33166	Recruiting
Brainstorm Research	Miami	Florida	33176	Active, not recruiting
Advanced Research for Health Improvement, LLC/ Dr. Cordero's Pediatric Office	Naples	Florida	34102	Active, not recruiting
Aqualane Clinical Research	Naples	Florida	34105	Recruiting
Coastal Clinical Research Specialists	Orange Park	Florida	32073	Active, not recruiting
Clinical Associates of Orlando, LLC	Orlando	Florida	32819	Recruiting
Bioresearch Institute	Pembroke Pines	Florida	33026	Terminated
Forcare Clinical Research	Tampa	Florida	33613	Active, not recruiting
Premiere Research Institute at Palm Beach Neurology	West Palm Beach	Florida	33407	Active, not recruiting
Children's Healthcare of Atlanta, Inc.	Atlanta	Georgia	30329	Recruiting
Childrens Healthcare of Atlanta	Atlanta	Georgia	30329	Recruiting
Rare Disease Research, LLC	Atlanta	Georgia	30329	Active, not recruiting
Pivotal Clinical Research & Associates, LLC	Brunswick	Georgia	31520	Recruiting
CenExel iResearch, LLC	Decatur	Georgia	30030	Recruiting
Chicago Headache Center & Research Institute	Chicago	Illinois	60657	Recruiting
AMR-Baber Research Inc	Naperville	Illinois	60563	Recruiting
Options Research Group, LLC	Westfield	Indiana	46074	Recruiting
Velocity Clinical Research, Sioux City	Sioux City	Iowa	51106	Recruiting
Integrated Clinical Trial Services	West Des Moines	Iowa	50265	Recruiting
Clinical Associates Midwest, LLC	Kansas City	Kansas	66214	Recruiting
College Park Family Care Center Physicians Group- Neurology Research Dept.	Overland Park	Kansas	66212	Active, not recruiting
Kentucky Neuroscience Institute Child Neurology-- "Patients Seen"	Lexington	Kentucky	40504	Active, not recruiting
UK Center for Clinical and Translational Science (CCTS) -- "Patients Seen"	Lexington	Kentucky	40536	Active, not recruiting
University of Kentucky Hospital	Lexington	Kentucky	40536	Active, not recruiting
Ochsner Clinic Foundation	New Orleans	Louisiana	70121	Active, not recruiting
Neurology and Headache Center, Inc.	Shreveport	Louisiana	71105	Active, not recruiting
Boston Clinical Trials	Boston	Massachusetts	02131	Active, not recruiting
MedVadis Research Corporation	Waltham	Massachusetts	02451	Active, not recruiting
Michigan Head Pain & Neurological Institute	Ann Arbor	Michigan	48104	Recruiting
Corewell Health, for and on behalf of Spectrum Health Hospital and Corewell Health Medical Group	Grand Rapids	Michigan	49503	Recruiting
Corewell Health, Helen DeVos Children's Hospital	Grand Rapids	Michigan	49503	Recruiting
Wellnow Urgent Care and Research	Kalamazoo	Michigan	49048	Active, not recruiting
Beaumont Hospital Royal Oak Campus	Royal Oak	Michigan	48073	Recruiting
Brackenridge Outpatient Research Pharmacy	Rochester	Minnesota	55905	Recruiting
Clinical Research Trials Unit	Rochester	Minnesota	55905	Recruiting
Mayo Clinic	Rochester	Minnesota	55905	Recruiting
Precise Research Centers	Flowood	Mississippi	39232	Recruiting
Sharlin Health Neuroscience Research Center	Ozark	Missouri	65721	Active, not recruiting
Clinvest Research, LLC	Springfield	Missouri	65810	Active, not recruiting
Boeson Research	Great Falls	Montana	59405	Recruiting
Boeson Research	Kalispell	Montana	59901	Active, not recruiting
Heart & Hands Midwifery	Kalispell	Montana	59901	Active, not recruiting
Blue Moose Pediatrics	Missoula	Montana	59804	Recruiting
Boeson Research Laboratory	Missoula	Montana	59804	Recruiting
Boeson Research	Missoula	Montana	59804	Recruiting
Alivation Research, LLC.	Lincoln	Nebraska	68526	Terminated
Children's Hospital & Medical Center	Omaha	Nebraska	68114	Recruiting
HMH Jersey Shore University Medical Center	Neptune City	New Jersey	07753	Recruiting
HOPE Tower at Jersey Shore University Medical Center	Neptune City	New Jersey	07753	Recruiting
Dent Neurosciences Research Center	Amherst	New York	14226	Recruiting
True North Neurology	Commack	New York	11725	Recruiting
Northwell Health/ Division of Pediatric Neurology	Lake Success	New York	11042	Recruiting
NYU Langone Hospital-Long Island, Clinical Research Center	Mineola	New York	11501	Active, not recruiting
NYU Langone Hospital-Long Island, Pediatric Neurology	Mineola	New York	11501	Active, not recruiting
New York Neurology Associates	New York	New York	10003	Recruiting
Weill Cornell Medicine	New York	New York	10021	Recruiting
Mount Sinai Hospital - Pharmacy Department	New York	New York	10029	Active, not recruiting
Columbia University Medical Center Research Pharmacy	New York	New York	10032	Active, not recruiting
Columbia University Pediatric Neuromuscular Center	New York	New York	10032	Active, not recruiting
Irving Center for Clinical and Translational Research, Outpatient Clinical Research Unit	New York	New York	10032	Active, not recruiting
The Neurological Institute of New York	New York	New York	10032	Active, not recruiting
The Trustees of Columbia University and The New York and Presbyterian Hospital	New York	New York	10032	Active, not recruiting
North Suffolk Neurology P.C	Port Jefferson Station	New York	11776	Active, not recruiting
Finger Lakes Clinical Research	Rochester	New York	14618	Terminated
Prime Global Research, LLC	The Bronx	New York	10456	Terminated
New Hope Clinical Research	Charlotte	North Carolina	28211	Active, not recruiting
OnSite Clinical Solutions, LLC	Charlotte	North Carolina	28277	Recruiting
Velocity Clinical Research, Inc.	Durham	North Carolina	27701	Recruiting
Headache Wellness Center, PC	Greensboro	North Carolina	27405	Recruiting
Akron Children's Hospital	Akron	Ohio	44308	Recruiting
Cincinnati Children's Hospital Medical Center	Cincinnati	Ohio	45229	Recruiting
Velocity Clinical Research	Cincinnati	Ohio	45242	Recruiting
University Hospitals Cleveland Medical Center	Cleveland	Ohio	44106	Recruiting
Nationwide Children's Hospital	Columbus	Ohio	43205	Active, not recruiting
Wellnow Urgent Care and Research	Columbus	Ohio	43228	Active, not recruiting
Neuro-Behavioral Clinical Research, Inc.	North Canton	Ohio	44720	Active, not recruiting
IPS Research Company	Oklahoma City	Oklahoma	73106	Active, not recruiting
Lynn Institute of Tulsa	Tulsa	Oklahoma	74135	Active, not recruiting
Velocity Clinical Research, Grants Pass	Grants Pass	Oregon	97527	Active, not recruiting
Providence Neuroscience Institute - Research Coordinator's Office	Portland	Oregon	97225	Recruiting
Providence Pediatric Neurology	Portland	Oregon	97225	Recruiting
Providence St. Vincent Medical Center	Portland	Oregon	97225	Recruiting
Clario	Philadelphia	Pennsylvania	19103	Recruiting
Children's Hospital of Philadelphia	Philadelphia	Pennsylvania	19104	Active, not recruiting
Velocity Clinical Research-Providence	East Greenwich	Rhode Island	02818	Recruiting
Premier Neurology, PC	Greenville	South Carolina	29605	Active, not recruiting
Tribe Clinical Research, LLC	Greenville	South Carolina	29607	Active, not recruiting
Velocity Clinical Research - Greenville	Greenville	South Carolina	29615	Active, not recruiting
Holston Medical Group.	Kingsport	Tennessee	37660	Active, not recruiting
Holston Medical Group	Kingsport	Tennessee	37660	Active, not recruiting
Le Bonheur Children's Hospital - Outpatient Building	Memphis	Tennessee	38103	Recruiting
Le Bonheur Children's Hospital	Memphis	Tennessee	38103	Recruiting
Le Bonheur Childrens Hospital - Childrens Foundation Research Institute	Memphis	Tennessee	38103	Recruiting
Le Bonheur Outpatient Pharmacy	Memphis	Tennessee	38105	Recruiting
Access Clinical Trials, Inc.	Nashville	Tennessee	37203	Active, not recruiting
Dell Children's Medical Center	Austin	Texas	78723	Recruiting
Child Neurology Consultants of Austin - South Austin	Austin	Texas	78749	Recruiting
Child Neurology Consultants of Austin - Central Austin	Austin	Texas	78757	Recruiting
BioBehavioral Research of Austin	Austin	Texas	78759	Active, not recruiting
Houston Clinical Trials, LLC	Bellaire	Texas	77401	Recruiting
Infinite Research Group, LLC	Dallas	Texas	75201	Active, not recruiting
Children's Medical Center, Dallas	Dallas	Texas	75235	Recruiting
Children's Medical Center, Pediatric Anesthesiology Research (Study supplies only)	Dallas	Texas	75235	Recruiting
Cedar Health Research	Dallas	Texas	75251	Active, not recruiting
FutureSearch Trials of Dallas, LLC	Dallas	Texas	75251	Recruiting
The University of Texas Southwestern Medical Center	Dallas	Texas	75390	Recruiting
ANESC Research	El Paso	Texas	79912	Recruiting
North Texas Institute of Neurology and Headache	Frisco	Texas	75034	Active, not recruiting
UTHealth Houston	Houston	Texas	77030	Recruiting
Pain and Headache Centers of Texas	Houston	Texas	77054	Recruiting
SCLA Management	Houston	Texas	77077	Recruiting
Houston Clinical Research,LLC.	Houston	Texas	77081	Active, not recruiting
NeuroCare Plus	Houston	Texas	77094	Recruiting
AIM Trials, LLC	Plano	Texas	75093	Recruiting
JBR Clinical Research	Salt Lake City	Utah	84107	Recruiting
Wasatch Clinical Research , LLC(Administrative Location)	Salt Lake City	Utah	84107	Recruiting
The University of Vermont Medical Center	Burlington	Vermont	05401	Active, not recruiting
Pediatric Associates of Charlottesville, PLC (Private Pediatric Practice)	Charlottesville	Virginia	22902	Recruiting
Pediatric Research of Charlottesville, LLC (Regulatory Only)	Charlottesville	Virginia	22902	Recruiting
Pediatric Research of Charlottesville, LLC	Charlottesville	Virginia	22902	Recruiting
Children's Hospital of the King's Daughters	Norfolk	Virginia	23507	Recruiting
Children's Specialty Group, PLLC	Norfolk	Virginia	23507	Recruiting
Children's Specialty Group, PLLC, Division of Childhood & Adolescent Neurology	Norfolk	Virginia	23510	Recruiting
National Clinical Research, Inc.	Richmond	Virginia	23294	Active, not recruiting
Northwest Clinical Research Center	Bellevue	Washington	98007	Recruiting
Eastside Therapeutic Resource, Inc. dba Core Clinical Research	Everett	Washington	98201	Active, not recruiting
Seattle Children's Hospital Investigational Drug Services	Seattle	Washington	98105	Recruiting
Seattle Children's Hospital	Seattle	Washington	98105	Recruiting
Clinical Investigation Specialists, Inc	Kenosha	Wisconsin	53144	Recruiting
University Hospital	Madison	Wisconsin	53792	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 77 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT04649242, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 19, 2026 · Synced May 20, 2026

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The complete protocol, eligibility criteria, and contact information for NCT04649242 live on ClinicalTrials.gov.

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