A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors
Public ClinicalTrials.gov record NCT04657068. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase I/IIa, Open-label, Multi-center Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of the ATR Kinase Inhibitor ART0380 Administered Orally as Monotherapy and in Combination to Patients With Advanced or Metastatic Solid Tumors
Study identification
- NCT ID
- NCT04657068
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Lead sponsor
- Artios Pharma Ltd
- Industry
- Enrollment
- 442 participants
Conditions and interventions
Conditions
Interventions
- ART0380 Drug
- Gemcitabine Drug
- Irinotecan Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 26, 2021
- Primary completion
- Nov 30, 2026
- Completion
- Nov 30, 2027
- Last update posted
- Mar 17, 2026
2021 – 2027
United States locations
- U.S. sites
- 40
- U.S. states
- 21
- U.S. cities
- 36
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35294-3300 | Recruiting |
| Mayo Clinic (Arizona) | Scottsdale | Arizona | 85259 | Recruiting |
| University of Arkansas - Winthrop P. Rockefeller Cancer Institute | Little Rock | Arkansas | 72205 | Recruiting |
| USC Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | Recruiting |
| Sansum Clinic | Santa Barbara | California | 93105 | Recruiting |
| Providence Medical Foundation | Santa Rosa | California | 95403 | Recruiting |
| Rocky Mountain Cancer Center | Denver | Colorado | 80218 | Recruiting |
| Sarah Cannon Research Institute at HealthONE | Denver | Colorado | 80218 | Recruiting |
| Florida Cancer Specialists | Fort Myers | Florida | 33901 | Recruiting |
| Mayo Clinic (Florida) | Jacksonville | Florida | 32224 | Recruiting |
| Cancer Specialists of North Florida | Jacksonville | Florida | 32256 | Recruiting |
| Florida Cancer Specialists | Orlando | Florida | 32827 | Completed |
| Florida Cancer Specialists | Sarasota | Florida | 34232 | Recruiting |
| Florida Cancer Specialists | West Palm Beach | Florida | 33401 | Recruiting |
| Hope and Healing Cancer Services | Hinsdale | Illinois | 60521 | Recruiting |
| Community Health Network | Indianapolis | Indiana | 46250 | Recruiting |
| Our Lady of the Lake | Baton Rouge | Louisiana | 70808 | Recruiting |
| Maryland Oncology Hematology - Primary | Columbia | Maryland | 21044 | Recruiting |
| Minnesota Oncology Hematology | Maple Grove | Minnesota | 55369 | Recruiting |
| Mayo Clinic (Minnesota) | Rochester | Minnesota | 55905 | Recruiting |
| Washington University | St Louis | Missouri | 63110 | Recruiting |
| Hematology Oncology Associates of Central New York | East Syracuse | New York | 13057 | Recruiting |
| Northwell Health Cancer Institute | Lake Success | New York | 11042 | Recruiting |
| Oncology Hematology Care Primary | Cincinnati | Ohio | 45242 | Recruiting |
| Taylor Cancer Research Center | Maumee | Ohio | 43537 | Recruiting |
| Stephenson Cancer Center | Oklahoma City | Oklahoma | 73104 | Recruiting |
| Oregon Health & Science University | Portland | Oregon | 97239 | Recruiting |
| University of Pennsylvania / Abramson Cancer Center | Philadelphia | Pennsylvania | 19104 | Recruiting |
| Thomas Jefferson University, Sidney Kimmel Cancer Center, Clinical Research Organization | Philadelphia | Pennsylvania | 19107 | Recruiting |
| Tennessee Oncology, PLLC | Chattanooga | Tennessee | 37404 | Recruiting |
| Baptist Cancer Center | Memphis | Tennessee | 38120 | Completed |
| SCRI Oncology Partners | Nashville | Tennessee | 37203 | Recruiting |
| Texas Oncology - Central/South Texas | Austin | Texas | 78705 | Recruiting |
| Mary Crowley Cancer Research | Dallas | Texas | 75230 | Recruiting |
| Texas Oncology - Baylor Charles A. Sammons Cancer Center | Dallas | Texas | 75246 | Recruiting |
| Texas Oncology - Northeast Texas | Flower Mound | Texas | 75028 | Recruiting |
| Oncology Consultants | Houston | Texas | 77030 | Completed |
| Texas Oncology - San Antonio | San Antonio | Texas | 78240 | Recruiting |
| Utah Cancer Specialists | Salt Lake City | Utah | 84106 | Recruiting |
| Virginia Cancer Specialists | Fairfax | Virginia | 22031 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 39 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04657068, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 17, 2026 · Synced May 10, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04657068 live on ClinicalTrials.gov.