Efficacy and Safety of MK-1942 When Added to Stable Antidepressant Therapy in Participants With Treatment-Resistant Depression (TRD) (MK-1942-006)
Public ClinicalTrials.gov record NCT04663321. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2a, Randomized, Placebo-Controlled Clinical Study to Evaluate the Efficacy and Safety of MK-1942 Added to Stable Antidepressant Therapy in Participants With Treatment-Resistant Depression
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The main purpose of this study is to assess the efficacy and safety of daily and intermittent dosing of MK-1942 compared to placebo among participants with Treatment-Resistant Depression (TRD) on a stable course of antidepressant therapy. The dual primary hypotheses of the study are that the daily MK-1942 treatment or intermittent MK-1942 treatment are superior to placebo in reducing Montgomery-Asberg Depression Rating Scale (MADRS) score.
Study identification
- NCT ID
- NCT04663321
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 99 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 19, 2021
- Primary completion
- Sep 7, 2023
- Completion
- Sep 7, 2023
- Last update posted
- May 3, 2026
2021 – 2023
United States locations
- U.S. sites
- 45
- U.S. states
- 22
- U.S. cities
- 43
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham - School of Medicine-Psychiatry ( Site 1073) | Birmingham | Alabama | 35233 | — |
| Preferred Research Partners ( Site 1079) | Little Rock | Arkansas | 72211 | — |
| Woodland International Research Group ( Site 1017) | Little Rock | Arkansas | 72211 | — |
| CITrials-Outpatient Facility ( Site 1098) | Bellflower | California | 90706 | — |
| Axiom Research ( Site 1053) | Colton | California | 92324 | — |
| Collaborative Neuroscience Network, LLC. ( Site 1032) | Garden Grove | California | 92845 | — |
| CITrials ( Site 1105) | Santa Ana | California | 92705 | — |
| Institute of Living ( Site 1061) | Hartford | Connecticut | 06106 | — |
| Gulfcoast Clinical Research Center ( Site 1110) | Fort Myers | Florida | 33912 | — |
| Velocity Clinical Research, Hallandale Beach ( Site 1116) | Hallandale | Florida | 33009 | — |
| Clinical Neuroscience Solutions, Inc. dba CNS Healthcare ( Site 1039) | Jacksonville | Florida | 32256 | — |
| Innovative Clinical Research ( Site 1044) | Lauderhill | Florida | 33319 | — |
| Behavioral Clinical Research ( Site 1037) | Miami | Florida | 33016 | — |
| Aqualane Clinical Research ( Site 1113) | Naples | Florida | 34105 | — |
| APG RESEARCH, LLC ( Site 1087) | Orlando | Florida | 32803 | — |
| University of South Florida-Psychiatry and Behavioral Neurosciences ( Site 1093) | Tampa | Florida | 33613 | — |
| K2 Medical Research - Winter Park ( Site 1115) | Winter Park | Florida | 32792 | — |
| Atlanta Center for Medical Research ( Site 1022) | Atlanta | Georgia | 30331 | — |
| iResearch Atlanta ( Site 1040) | Decatur | Georgia | 30030 | — |
| Psych Atlanta ( Site 1108) | Marietta | Georgia | 30060 | — |
| iResearch Savannah ( Site 1041) | Savannah | Georgia | 31405 | — |
| Ascension Saint Elizabeth ( Site 1003) | Chicago | Illinois | 60622 | — |
| CBH Health ( Site 1076) | Gaithersburg | Maryland | 20877 | — |
| Boston Clinical Trials ( Site 1028) | Boston | Massachusetts | 02131 | — |
| University of Michigan-Psychiatry ( Site 1051) | Ann Arbor | Michigan | 48026 | — |
| Altea Research ( Site 1018) | Las Vegas | Nevada | 89102 | — |
| Hassman Research Institute ( Site 1036) | Berlin | New Jersey | 08009 | — |
| Global Medical Institutes LLC; Princeton Medical Institute ( Site 1049) | Princeton | New Jersey | 08540 | — |
| Albuquerque Neuroscience Inc. ( Site 1107) | Albuquerque | New Mexico | 87109 | — |
| Hapworth Research Inc.-Clinical Research Department ( Site 1090) | New York | New York | 10022 | — |
| Manhattan Behavioral Medicine ( Site 1096) | New York | New York | 10036 | — |
| Richmond Behavioral Associates ( Site 1011) | Staten Island | New York | 10314 | — |
| New Hope Clinical Research ( Site 1082) | Charlotte | North Carolina | 28211 | — |
| Clinical Trials of America, LLC ( Site 1103) | Hickory | North Carolina | 28601 | — |
| Neuro-Behavioral Clinical Research ( Site 1045) | North Canton | Ohio | 44720 | — |
| Paradigm Research Professionals ( Site 1089) | Oklahoma City | Oklahoma | 73118 | — |
| Suburban Research Associates-Clinical Research ( Site 1042) | Media | Pennsylvania | 19063 | — |
| Penn Medicine: University of Pennsylvania Health System-Mood Disorders Treatment and Research Proga | Philadelphia | Pennsylvania | 19104 | — |
| Keystone Clinical Studies ( Site 1031) | Plymouth Meeting | Pennsylvania | 19462 | — |
| Baylor College of Medicine ( Site 1019) | Houston | Texas | 77030 | — |
| AIM Trials, LLC ( Site 1111) | Plano | Texas | 75093 | — |
| Cedar Clinical Research ( Site 1023) | Draper | Utah | 84020 | — |
| Woodstock Research Center ( Site 1084) | Woodstock | Vermont | 05091 | — |
| Northwest Clinical Research Center ( Site 1112) | Bellevue | Washington | 98007 | — |
| Core Clinical Research ( Site 1081) | Everett | Washington | 98201 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04663321, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 3, 2026 · Synced Sep 25, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04663321 live on ClinicalTrials.gov.