ClinicalTrials.gov record
Efficacy and Safety of MK-1942 When Added to Stable Antidepressant Therapy in Participants With Treatment-Resistant Depression (TRD) (MK-1942-006)
ClinicalTrials.gov ID: NCT04663321
Public ClinicalTrials.gov record NCT04663321. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 18, 2026, 12:22 PM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2a, Randomized, Placebo-Controlled Clinical Study to Evaluate the Efficacy and Safety of MK-1942 Added to Stable Antidepressant Therapy in Participants With Treatment-Resistant Depression
Study identification
- NCT ID
- NCT04663321
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Merck Sharp & Dohme LLC
- Industry
- Enrollment
- 99 participants
Conditions and interventions
Conditions
Interventions
- MK-1942 Drug
- Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 19, 2021
- Primary completion
- Sep 7, 2023
- Completion
- Sep 7, 2023
- Last update posted
- May 3, 2026
2021 – 2023
United States locations
- U.S. sites
- 45
- U.S. states
- 22
- U.S. cities
- 43
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham - School of Medicine-Psychiatry ( Site 1073) | Birmingham | Alabama | 35233 | — |
| Preferred Research Partners ( Site 1079) | Little Rock | Arkansas | 72211 | — |
| Woodland International Research Group ( Site 1017) | Little Rock | Arkansas | 72211 | — |
| CITrials-Outpatient Facility ( Site 1098) | Bellflower | California | 90706 | — |
| Axiom Research ( Site 1053) | Colton | California | 92324 | — |
| Collaborative Neuroscience Network, LLC. ( Site 1032) | Garden Grove | California | 92845 | — |
| CITrials ( Site 1105) | Santa Ana | California | 92705 | — |
| Institute of Living ( Site 1061) | Hartford | Connecticut | 06106 | — |
| Gulfcoast Clinical Research Center ( Site 1110) | Fort Myers | Florida | 33912 | — |
| Velocity Clinical Research, Hallandale Beach ( Site 1116) | Hallandale | Florida | 33009 | — |
| Clinical Neuroscience Solutions, Inc. dba CNS Healthcare ( Site 1039) | Jacksonville | Florida | 32256 | — |
| Innovative Clinical Research ( Site 1044) | Lauderhill | Florida | 33319 | — |
| Behavioral Clinical Research ( Site 1037) | Miami | Florida | 33016 | — |
| Aqualane Clinical Research ( Site 1113) | Naples | Florida | 34105 | — |
| APG RESEARCH, LLC ( Site 1087) | Orlando | Florida | 32803 | — |
| University of South Florida-Psychiatry and Behavioral Neurosciences ( Site 1093) | Tampa | Florida | 33613 | — |
| K2 Medical Research - Winter Park ( Site 1115) | Winter Park | Florida | 32792 | — |
| Atlanta Center for Medical Research ( Site 1022) | Atlanta | Georgia | 30331 | — |
| iResearch Atlanta ( Site 1040) | Decatur | Georgia | 30030 | — |
| Psych Atlanta ( Site 1108) | Marietta | Georgia | 30060 | — |
| iResearch Savannah ( Site 1041) | Savannah | Georgia | 31405 | — |
| Ascension Saint Elizabeth ( Site 1003) | Chicago | Illinois | 60622 | — |
| CBH Health ( Site 1076) | Gaithersburg | Maryland | 20877 | — |
| Boston Clinical Trials ( Site 1028) | Boston | Massachusetts | 02131 | — |
| University of Michigan-Psychiatry ( Site 1051) | Ann Arbor | Michigan | 48026 | — |
| Altea Research ( Site 1018) | Las Vegas | Nevada | 89102 | — |
| Hassman Research Institute ( Site 1036) | Berlin | New Jersey | 08009 | — |
| Global Medical Institutes LLC; Princeton Medical Institute ( Site 1049) | Princeton | New Jersey | 08540 | — |
| Albuquerque Neuroscience Inc. ( Site 1107) | Albuquerque | New Mexico | 87109 | — |
| Hapworth Research Inc.-Clinical Research Department ( Site 1090) | New York | New York | 10022 | — |
| Manhattan Behavioral Medicine ( Site 1096) | New York | New York | 10036 | — |
| Richmond Behavioral Associates ( Site 1011) | Staten Island | New York | 10314 | — |
| New Hope Clinical Research ( Site 1082) | Charlotte | North Carolina | 28211 | — |
| Clinical Trials of America, LLC ( Site 1103) | Hickory | North Carolina | 28601 | — |
| Neuro-Behavioral Clinical Research ( Site 1045) | North Canton | Ohio | 44720 | — |
| Paradigm Research Professionals ( Site 1089) | Oklahoma City | Oklahoma | 73118 | — |
| Suburban Research Associates-Clinical Research ( Site 1042) | Media | Pennsylvania | 19063 | — |
| Penn Medicine: University of Pennsylvania Health System-Mood Disorders Treatment and Research Proga | Philadelphia | Pennsylvania | 19104 | — |
| Keystone Clinical Studies ( Site 1031) | Plymouth Meeting | Pennsylvania | 19462 | — |
| Baylor College of Medicine ( Site 1019) | Houston | Texas | 77030 | — |
| AIM Trials, LLC ( Site 1111) | Plano | Texas | 75093 | — |
| Cedar Clinical Research ( Site 1023) | Draper | Utah | 84020 | — |
| Woodstock Research Center ( Site 1084) | Woodstock | Vermont | 05091 | — |
| Northwest Clinical Research Center ( Site 1112) | Bellevue | Washington | 98007 | — |
| Core Clinical Research ( Site 1081) | Everett | Washington | 98201 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04663321, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 3, 2026 · Synced May 18, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04663321 live on ClinicalTrials.gov.