Cryoablation Combined With Stereotactic Body Radiation Therapy for the Treatment of Painful Bone Metastases, the CROME Trial
Public ClinicalTrials.gov record NCT04693377. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Cryoablation Combined With Stereotactic Body Radiation Therapy for the Treatment of Painful Bone Metastases
Study identification
- NCT ID
- NCT04693377
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Not applicable
- Lead sponsor
- M.D. Anderson Cancer Center
- Other
- Enrollment
- 40 participants
Conditions and interventions
Conditions
- Castration-Resistant Prostate Carcinoma
- Metastatic Colorectal Carcinoma
- Metastatic Malignant Neoplasm in the Bone
- Metastatic Malignant Solid Neoplasm
- Metastatic Melanoma
- Metastatic Prostate Carcinoma
- Metastatic Renal Cell Carcinoma
- Metastatic Sarcoma
- Metastatic Thyroid Gland Carcinoma
- Metastatic Urothelial Carcinoma
- Stage IV Colorectal Cancer AJCC v8
- Stage IV Prostate Cancer AJCC v8
- Stage IV Renal Cell Cancer AJCC v8
- Stage IVA Colorectal Cancer AJCC v8
- Stage IVA Prostate Cancer AJCC v8
- Stage IVB Colorectal Cancer AJCC v8
- Stage IVB Prostate Cancer AJCC v8
- Stage IVC Colorectal Cancer AJCC v8
Interventions
- Cryosurgery Procedure
- Quality-of-Life Assessment Other
- Stereotactic Body Radiation Therapy Radiation
Procedure · Other · Radiation
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 15, 2021
- Primary completion
- Mar 31, 2027
- Completion
- Mar 31, 2027
- Last update posted
- Apr 14, 2026
2021 – 2027
United States locations
- U.S. sites
- 1
- U.S. states
- 1
- U.S. cities
- 1
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| M D Anderson Cancer Center | Houston | Texas | 77030 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04693377, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 14, 2026 · Synced May 5, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04693377 live on ClinicalTrials.gov.