Substudy 02D: Safety and Efficacy of Pembrolizumab in Combination With Investigational Agents or Pembrolizumab Alone in Participants With Melanoma Brain Metastasis (MK-3475-02D/KEYMAKER-U02)
Public ClinicalTrials.gov record NCT04700072. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 1/2 Open-Label Rolling-Arm Umbrella Platform Design of Investigational Agents With or Without Pembrolizumab or Pembrolizumab Alone in Participants With Melanoma (KEYMAKER-U02): Substudy 02D
Study identification
- NCT ID
- NCT04700072
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Lead sponsor
- Merck Sharp & Dohme LLC
- Industry
- Enrollment
- 56 participants
Conditions and interventions
Conditions
Interventions
- Lenvatinib Drug
- Pembrolizumab Biological
- Pembrolizumab/Quavonlimab Biological
Drug · Biological
Eligibility (public fields only)
- Age range
- 18 Years to 120 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 2, 2021
- Primary completion
- Oct 16, 2025
- Completion
- Oct 16, 2025
- Last update posted
- Oct 27, 2025
2021 – 2025
United States locations
- U.S. sites
- 9
- U.S. states
- 7
- U.S. cities
- 8
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| The Angeles Clinic and Research Institute ( Site 4009) | Los Angeles | California | 90025 | — |
| UCLA Hematology & Oncology ( Site 4004) | Los Angeles | California | 90095 | — |
| Providence Saint John's Health Center ( Site 4010) | Santa Monica | California | 90404 | — |
| University of Colorado, Anschutz Cancer Pavilion ( Site 4012) | Aurora | Colorado | 80045 | — |
| Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins ( Site 4022) | Baltimore | Maryland | 21287 | — |
| NYU Clinical Cancer Center ( Site 4002) | New York | New York | 10016 | — |
| Duke Cancer Institute ( Site 4005) | Durham | North Carolina | 27710 | — |
| Martha Morehouse Tower ( Site 4020) | Columbus | Ohio | 43221 | — |
| Inova Schar Cancer Institute ( Site 4011) | Fairfax | Virginia | 22031 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 27 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04700072, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 27, 2025 · Synced May 11, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04700072 live on ClinicalTrials.gov.