ClinicalTrials.gov record
Pivotal 1 Study of ABBV-RGX-314 (Also Known as RGX-314) Gene Therapy Administered Via Subretinal Delivery One Time in Participants With nAMD
ClinicalTrials.gov ID: NCT04704921
Public ClinicalTrials.gov record NCT04704921. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 8, 2026, 8:10 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Partially Masked, Controlled, Phase 2b/3 Clinical Study to Evaluate the Efficacy and Safety of RGX-314 Gene Therapy in Participants With nAMD (ATMOSPHERE)
Study identification
- NCT ID
- NCT04704921
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Lead sponsor
- AbbVie
- Industry
- Enrollment
- 671 participants
Conditions and interventions
Conditions
Interventions
- ABBV-RGX-314 Genetic
- Ranibizumab (LUCENTIS®) Biological
Genetic · Biological
Eligibility (public fields only)
- Age range
- 50 Years to 89 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 28, 2020
- Primary completion
- Nov 30, 2026
- Completion
- Oct 31, 2027
- Last update posted
- Apr 27, 2026
2020 – 2027
United States locations
- U.S. sites
- 89
- U.S. states
- 34
- U.S. cities
- 80
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Retinal Research Institute /ID# 256019 | Phoenix | Arizona | 85053 | — |
| Barnet Dulaney Perkins Eye Center - Sun City /ID# 256055 | Sun City | Arizona | 85351 | — |
| University of Arkansas for Medical Sciences /ID# 271290 | Little Rock | Arkansas | 72205 | — |
| Retina Vitreous Assoc Med Grp /ID# 256299 | Beverly Hills | California | 90211 | — |
| Retinal Diagnostic Center /ID# 256137 | Campbell | California | 95008 | — |
| The Retina Partners - Encino /ID# 256054 | Encino | California | 91436 | — |
| Retina Consultants of Orange County /ID# 256152 | Fullerton | California | 92835 | — |
| Salehi Retina Institute /ID# 263485 | Huntington Beach | California | 92647 | — |
| UC Irvine/Gavin Herbert Eye Institute /ID# 256145 | Irvine | California | 92697 | — |
| Northern California Retina Vitreous Associates Medical Group, Inc /ID# 256298 | Mountain View | California | 94040-4101 | — |
| UCLA Doheny Eye Center /ID# 256120 | Pasadena | California | 91105 | — |
| California Eye Specialists Medical Group Inc. /ID# 256079 | Pasadena | California | 91107 | — |
| Retina Consultants of San Diego /ID# 256021 | Poway | California | 92064-2530 | — |
| Retinal Consultants Medical Group /ID# 256047 | Sacramento | California | 95825 | — |
| West Coast Retina /ID# 256448 | San Francisco | California | 94107 | — |
| University of California, San Francisco /ID# 256130 | San Francisco | California | 94143 | — |
| Orange County Retina Medical Group /ID# 256073 | Santa Ana | California | 92705 | — |
| California Retina Consultants - Santa Barbara /ID# 256017 | Santa Barbara | California | 93103 | — |
| Retina Consultants of Southern Colorado /ID# 256069 | Colorado Springs | Colorado | 80909 | — |
| Southwest Retina Research Center /ID# 256136 | Durango | Colorado | 81303 | — |
| Colorado Retina Associates /ID# 256121 | Lakewood | Colorado | 80228 | — |
| Retina Group of New England - Waterford /ID# 256071 | Waterford | Connecticut | 06385-1215 | — |
| Advanced Research, LLC /ID# 275451 | Deerfield Beach | Florida | 33064-1342 | — |
| Vitreoretinal Associates, P.A. /ID# 256150 | Gainesville | Florida | 32607 | — |
| Florida Retina Consultants /ID# 265661 | Lakeland | Florida | 33805 | — |
| Bascom Palmer Eye Institute - University of Miami /ID# 256072 | Miami | Florida | 33136 | — |
| Retina Specialty Institute /ID# 256153 | Pensacola | Florida | 32503 | — |
| Retina Vitreous Associates of Florida - St. Petersburg /ID# 256050 | St. Petersburg | Florida | 33711-1141 | — |
| Southern Vitreoretinal Associates /ID# 256158 | Tallahassee | Florida | 32308 | — |
| Southeast Retina Center /ID# 256022 | Augusta | Georgia | 30909 | — |
| Georgia Retina - Marietta /ID# 256142 | Marietta | Georgia | 30060 | — |
| Marietta Eye Clinic /ID# 268163 | Marietta | Georgia | 30060 | — |
| Thomas Eye Group PC /ID# 268159 | Sandy Springs | Georgia | 30328-4411 | — |
| Retina Consultants of Hawaii /ID# 256049 | ‘Aiea | Hawaii | 96701 | — |
| University of Illinois at Chicago /ID# 256300 | Chicago | Illinois | 60607 | — |
| University Retina and Macula Associates /ID# 256078 | Lemont | Illinois | 60439 | — |
| University Retina and Macula Associates /ID# 256077 | Oak Forest | Illinois | 60452 | — |
| Springfield Clinic /ID# 266225 | Springfield | Illinois | 62702-3749 | — |
| Retina Partners Midwest, PC /ID# 256045 | Indianapolis | Indiana | 46290 | — |
| John-Kenyon American Eye Institute -New Albany /ID# 256065 | New Albany | Indiana | 47150-3620 | — |
| Retina Associates - Lenexa /ID# 256080 | Lenexa | Kansas | 66215 | — |
| Cincinnati Eye Institute- Edgewood /ID# 256132 | Edgewood | Kentucky | 41017-3415 | — |
| Retina Associates of New Orleans /ID# 272440 | Metairie | Louisiana | 70006-2940 | — |
| Ochsner Medical Center - Jefferson Highway /ID# 270524 | New Orleans | Louisiana | 70121 | — |
| The Retina Care Center /ID# 256144 | Baltimore | Maryland | 21209 | — |
| Johns Hopkins Hospital /ID# 256015 | Baltimore | Maryland | 21287 | — |
| The Retina Group Of Washington - Chevy Chase /ID# 276039 | Chevy Chase | Maryland | 20815 | — |
| Cumberland Valley Retina Consultants - Hagerstown /ID# 256151 | Hagerstown | Maryland | 21740 | — |
| Ophthalmic Consultants of Boston /ID# 256014 | Boston | Massachusetts | 02114 | — |
| Retina Associates of Michigan /ID# 266198 | Grand Blanc | Michigan | 48439 | — |
| Associated Retinal Consultants /ID# 256156 | Royal Oak | Michigan | 48073 | — |
| VitreoRetinal Surgery PLLC DBA Retina Consultants of Minnesota /ID# 256160 | Edina | Minnesota | 55435 | — |
| Mayo Clinic - Minnesota /ID# 256051 | Rochester | Minnesota | 55905 | — |
| The Retina Institute /ID# 266587 | St Louis | Missouri | 46214 | — |
| Sierra Eye Associates /ID# 256020 | Reno | Nevada | 89502 | — |
| Eye Associates of New Mexico /ID# 256075 | Albuquerque | New Mexico | 87109 | — |
| Long Island Vitreoretinal Consultants /ID# 256074 | Great Neck | New York | 11021 | — |
| Retina-Vitreous Surgeons of Central New York - Liverpool /ID# 266274 | Liverpool | New York | 13088 | — |
| Duke Eye Center /ID# 256076 | Durham | North Carolina | 27705 | — |
| Atrium Health Wake Forest Baptist Medical Center /ID# 270767 | Winston-Salem | North Carolina | 27157 | — |
| Retina Associates of Cleveland-Middleburg Heights /ID# 256052 | Cleveland | Ohio | 44130 | — |
| Cleveland Clinic Main Campus /ID# 256064 | Cleveland | Ohio | 44195 | — |
| Retina Vitreous Center, Research /ID# 256067 | Edmond | Oklahoma | 73013 | — |
| Verum Research, LLC /ID# 266585 | Eugene | Oregon | 97401 | — |
| Retina Northwest, PC /ID# 256140 | Portland | Oregon | 97221 | — |
| Erie Retina Research /ID# 256154 | Erie | Pennsylvania | 16507 | — |
| Retina Vitreous Consultants - Monroeville /ID# 271654 | Monroeville | Pennsylvania | 15146 | — |
| Mid Atlantic Retina /ID# 256013 | Philadelphia | Pennsylvania | 19107 | — |
| Charleston Neuroscience Institute /ID# 256235 | Ladson | South Carolina | 29456 | — |
| Black Hills Regional Eye Institute /ID# 256161 | Rapid City | South Dakota | 57701 | — |
| Charles Retina Institute /ID# 256016 | Germantown | Tennessee | 38138 | — |
| Retina Research Institute of Texas /ID# 256141 | Abilene | Texas | 79606-1224 | — |
| Austin Research Center for Retina /ID# 256148 | Austin | Texas | 78705 | — |
| Austin Retina Associates - Austin /ID# 256053 | Austin | Texas | 78705 | — |
| Austin Clinical Research, LLC /ID# 256043 | Austin | Texas | 78750-2298 | — |
| Retina Consultants of Texas - Beaumont /ID# 266279 | Beaumont | Texas | 77707 | — |
| Retina and Vitreous of Texas /ID# 263961 | Bellaire | Texas | 77401 | — |
| Texas Retina Associates - Dallas /ID# 256133 | Dallas | Texas | 75231 | — |
| Baylor Scott & White Surgicare /ID# 256122 | Fort Worth | Texas | 76104 | — |
| Retina Consultants Of Texas /ID# 268611 | San Antonio | Texas | 78240 | — |
| Stone Oak Surgery Center /ID# 266199 | San Antonio | Texas | 78240 | — |
| Retina Center Of Texas (Rct) - Southlake /ID# 256056 | Southlake | Texas | 76092 | — |
| Retina Consultants - The Woodlands /ID# 256018 | The Woodlands | Texas | 77384 | — |
| Retina Associates of Utah /ID# 256044 | Salt Lake City | Utah | 84107 | — |
| John A. Moran Eye Center /ID# 256068 | Salt Lake City | Utah | 84132 | — |
| Wagner Macula & Retina Center - Norfolk /ID# 256134 | Norfolk | Virginia | 23502 | — |
| Pacific Northwest Retina /ID# 256155 | Bellevue | Washington | 98004 | — |
| Retina Center NW, PLLC /ID# 256157 | Silverdale | Washington | 98383 | — |
| University of Wisconsin-Madison, Department of Ophthalmology and Visual Sciences /ID# 256159 | Madison | Wisconsin | 53705-3644 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04704921, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 27, 2026 · Synced May 8, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04704921 live on ClinicalTrials.gov.