A Comparative Study of AZD9833 Plus Palbociclib Versus Anastrozole Plus Palbociclib in Patients With ER-Positive HER2 Negative Breast Cancer Who Have Not Received Any Systemic Treatment for Advanced Disease
Public ClinicalTrials.gov record NCT04711252. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
SERENA-4: A Randomised, Multicentre, Double-Blind, Phase III Study of AZD9833 (an Oral SERD) Plus Palbociclib Versus Anastrozole Plus Palbociclib for the Treatment of Patients With Estrogen Receptor-Positive, HER2-Negative Advanced Breast Cancer Who Have Not Received Any Systemic Treatment for Advanced Disease
Study identification
- NCT ID
- NCT04711252
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- AstraZeneca
- Industry
- Enrollment
- 1,370 participants
Conditions and interventions
Conditions
Interventions
- AZD9833 Drug
- AZD9833 placebo Drug
- Anastrozole Drug
- Anastrozole placebo Drug
- Luteinizing hormone-releasing hormone (LHRH) agonist Drug
- Palbociclib Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 130 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 27, 2021
- Primary completion
- Aug 23, 2026
- Completion
- Jan 31, 2029
- Last update posted
- Oct 13, 2025
2021 – 2029
United States locations
- U.S. sites
- 30
- U.S. states
- 21
- U.S. cities
- 28
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Research Site | Mobile | Alabama | 36604 | — |
| Research Site | Springdale | Arkansas | 72762 | — |
| Research Site | Harbor City | California | 90710 | — |
| Research Site | Solvang | California | 93463 | — |
| Research Site | Lone Tree | Colorado | 80124 | — |
| Research Site | Fort Myers | Florida | 33901-8101 | — |
| Research Site | Jacksonville | Florida | 32256 | — |
| Research Site | West Palm Beach | Florida | 33401 | — |
| Research Site | Indianapolis | Indiana | 46256 | — |
| Research Site | Baton Rouge | Louisiana | 70809 | — |
| Research Site | Silver Spring | Maryland | 20904 | — |
| Research Site | Boston | Massachusetts | 02114 | — |
| Research Site | Detroit | Michigan | 48202 | — |
| Research Site | Hattiesburg | Mississippi | 39401 | — |
| Research Site | Omaha | Nebraska | 68130 | — |
| Research Site | Cincinnati | Ohio | 45219 | — |
| Research Site | Cincinnati | Ohio | 45267 | — |
| Research Site | Portland | Oregon | 97239 | — |
| Research Site | West Columbia | South Carolina | 29169 | — |
| Research Site | Sioux Falls | South Dakota | 57105 | — |
| Research Site | Chattanooga | Tennessee | 37404 | — |
| Research Site | Nashville | Tennessee | 37203 | — |
| Research Site | Austin | Texas | 78731 | — |
| Research Site | Houston | Texas | 77030 | — |
| Research Site | Houston | Texas | 77090 | — |
| Research Site | Tyler | Texas | 75702 | — |
| Research Site | Fairfax | Virginia | 22031 | — |
| Research Site | Kennewick | Washington | 99336 | — |
| Research Site | Renton | Washington | 98055 | — |
| Research Site | Morgantown | West Virginia | 26505 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 233 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04711252, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 13, 2025 · Synced May 8, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04711252 live on ClinicalTrials.gov.