ClinicalTrials.gov record
A Study of GSK3511294 (Depemokimab) Compared With Mepolizumab or Benralizumab in Participants With Severe Asthma With an Eosinophilic Phenotype
ClinicalTrials.gov ID: NCT04718389
Public ClinicalTrials.gov record NCT04718389. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A 52-week, Randomised, Double-blind, Double-dummy, Parallel Group, Multi-centre, Non-inferiority Study Assessing Exacerbation Rate, Additional Measures of Asthma Control and Safety in Adult and Adolescent Severe Asthmatic Participants With an Eosinophilic Phenotype Treated With GSK3511294 Compared With Mepolizumab or Benralizumab
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will assess whether switching participants who have benefitted from mepolizumab or benralizumab to GSK3511294 (Depemokimab) is non-inferior to maintaining current treatment on the annualized rate of clinically significant exacerbations in participants with severe asthma with an eosinophilic phenotype. Throughout the study, all participants will continue their non-biologic Baseline standard of care (SoC) asthma treatment.
Study identification
- NCT ID
- NCT04718389
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,717 participants
Conditions and interventions
Conditions
Interventions
- GSK3511294 (Depemokimab) Biological
- Mepolizumab Biological
- Benralizumab Biological
- Placebo Biological
- Standard of care (SoC) Drug
- Pre-filled Syringes (PFS) Device
Biological · Drug · Device
Eligibility (public fields only)
- Age range
- 12 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 26, 2021 (Actual)
- Primary completion
- Sep 14, 2025 (Actual)
- Completion
- Sep 14, 2025 (Actual)
- Last update posted
- May 18, 2026
2021 – 2025
United States locations
- U.S. sites
- 119
- U.S. states
- 33
- U.S. cities
- 97
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| GSK Investigational Site | Birmingham | Alabama | 35209 | — |
| GSK Investigational Site | Scottsboro | Alabama | 35768 | — |
| GSK Investigational Site | Litchfield Park | Arizona | 85340 | — |
| GSK Investigational Site | Phoenix | Arizona | 85054 | — |
| GSK Investigational Site | Scottsdale | Arizona | 85251 | — |
| GSK Investigational Site | Bakersfield | California | 93301 | — |
| GSK Investigational Site | Encinitas | California | 92024 | — |
| GSK Investigational Site | Huntington Beach | California | 92647 | — |
| GSK Investigational Site | Los Angeles | California | 90048 | — |
| GSK Investigational Site | Newport Beach | California | 92663 | — |
| GSK Investigational Site | Oxnard | California | 93036 | — |
| GSK Investigational Site | Rancho Cucamonga | California | 91730 | — |
| GSK Investigational Site | Redondo Beach | California | 90277 | — |
| GSK Investigational Site | Redwood City | California | 94063 | — |
| GSK Investigational Site | Riverside | California | 91786 | — |
| GSK Investigational Site | San Diego | California | 92123 | — |
| GSK Investigational Site | San Diego | California | 92307 | — |
| GSK Investigational Site | Valencia | California | 91324 | — |
| GSK Investigational Site | Woodland | California | 95695 | — |
| GSK Investigational Site | Aurora | Colorado | 80238 | — |
| GSK Investigational Site | Colorado Springs | Colorado | 80907 | — |
| GSK Investigational Site | Colorado Springs | Colorado | 80923 | — |
| GSK Investigational Site | Denver | Colorado | 80209 | — |
| GSK Investigational Site | Wheat Ridge | Colorado | 80033 | — |
| GSK Investigational Site | New Haven | Connecticut | 06511 | — |
| GSK Investigational Site | Aventura | Florida | 33180 | — |
| GSK Investigational Site | Clearwater | Florida | 33765-2103 | — |
| GSK Investigational Site | Fort Lauderdale | Florida | 33316 | — |
| GSK Investigational Site | Gainesville | Florida | 32610 | — |
| GSK Investigational Site | Hialeah | Florida | 33014 | — |
| GSK Investigational Site | Hialeah | Florida | 33016 | — |
| GSK Investigational Site | Jacksonville | Florida | 32209 | — |
| GSK Investigational Site | Kissimmee | Florida | 34746 | — |
| GSK Investigational Site | Loxahatchee Groves | Florida | 33470 | — |
| GSK Investigational Site | Miami | Florida | 33125 | — |
| GSK Investigational Site | Miami | Florida | 33126 | — |
| GSK Investigational Site | Miami | Florida | 33144 | — |
| GSK Investigational Site | Miami | Florida | 33166 | — |
| GSK Investigational Site | Miami | Florida | 33172 | — |
| GSK Investigational Site | Miami | Florida | 33186 | — |
| GSK Investigational Site | Miami Lakes | Florida | 33014 | — |
| GSK Investigational Site | Miami Lakes | Florida | 33125 | — |
| GSK Investigational Site | North Palm Beach | Florida | 33408 | — |
| GSK Investigational Site | Orlando | Florida | 32803 | — |
| GSK Investigational Site | Orlando | Florida | 32806 | — |
| GSK Investigational Site | Orlando | Florida | 32819 | — |
| GSK Investigational Site | Sebring | Florida | 33870 | — |
| GSK Investigational Site | Tallahassee | Florida | 32308 | — |
| GSK Investigational Site | Calhoun | Georgia | 30701 | — |
| GSK Investigational Site | Glenview | Illinois | 60077 | — |
| GSK Investigational Site | Evansville | Indiana | 47715 | — |
| GSK Investigational Site | Overland Park | Kansas | 66210 | — |
| GSK Investigational Site | Lexington | Kentucky | 40509 | — |
| GSK Investigational Site | Owensboro | Kentucky | 42301 | — |
| GSK Investigational Site | Bangor | Maine | 04401 | — |
| GSK Investigational Site | Baltimore | Maryland | 21162 | — |
| GSK Investigational Site | Baltimore | Maryland | 21224 | — |
| GSK Investigational Site | Chevy Chase | Maryland | 20815 | — |
| GSK Investigational Site | Boston | Massachusetts | 02115 | — |
| GSK Investigational Site | Burlington | Massachusetts | 01805 | — |
| GSK Investigational Site | New Bedford | Massachusetts | 02740 | — |
| GSK Investigational Site | North Dartmouth | Massachusetts | 02747 | — |
| GSK Investigational Site | Ann Arbor | Michigan | 48109 | — |
| GSK Investigational Site | Flint | Michigan | 48507 | — |
| GSK Investigational Site | Warren | Michigan | 48088 | — |
| GSK Investigational Site | Minneapolis | Minnesota | 55454 | — |
| GSK Investigational Site | Gulfport | Mississippi | 36608 | — |
| GSK Investigational Site | Jackson | Mississippi | 39216 | — |
| GSK Investigational Site | Chesterfield | Missouri | 63017 | — |
| GSK Investigational Site | Saint Charles | Missouri | 63301 | — |
| GSK Investigational Site | St Louis | Missouri | 63110 | — |
| GSK Investigational Site | Lincoln | Nebraska | 68505 | — |
| GSK Investigational Site | Omaha | Nebraska | 68198-5990 | — |
| GSK Investigational Site | Brick | New Jersey | 08724 | — |
| GSK Investigational Site | Northfield | New Jersey | 08225 | — |
| GSK Investigational Site | Riverdale | New Jersey | 07457 | — |
| GSK Investigational Site | Toms River | New Jersey | 08755 | — |
| GSK Investigational Site | Brooklyn | New York | 11215 | — |
| GSK Investigational Site | Corning | New York | 14845 | — |
| GSK Investigational Site | Great Neck | New York | 11040 | — |
| GSK Investigational Site | New York | New York | 60301 | — |
| GSK Investigational Site | The Bronx | New York | 10459-2417 | — |
| GSK Investigational Site | The Bronx | New York | 10467 | — |
| GSK Investigational Site | Asheville | North Carolina | 28803 | — |
| GSK Investigational Site | Huntersville | North Carolina | 28078 | — |
| GSK Investigational Site | Wilmington | North Carolina | 28401 | — |
| GSK Investigational Site | Winston-Salem | North Carolina | 27103 | — |
| GSK Investigational Site | Winston-Salem | North Carolina | 27157 | — |
| GSK Investigational Site | Cincinnati | Ohio | 45229 | — |
| GSK Investigational Site | Cincinnati | Ohio | 45231 | — |
| GSK Investigational Site | Corvallis | Oregon | 97330 | — |
| GSK Investigational Site | Altoona | Pennsylvania | 15801 | — |
| GSK Investigational Site | Altoona | Pennsylvania | 16601 | — |
| GSK Investigational Site | Hershey | Pennsylvania | 17033 | — |
| GSK Investigational Site | Philadelphia | Pennsylvania | 19140 | — |
| GSK Investigational Site | Pittsburgh | Pennsylvania | 15241 | — |
| GSK Investigational Site | Wyomissing | Pennsylvania | 19610 | — |
| GSK Investigational Site | Warwick | Rhode Island | 02886 | — |
| GSK Investigational Site | Rock Hill | South Carolina | 29732 | — |
| GSK Investigational Site | Spartanburg | South Carolina | 29303 | — |
| GSK Investigational Site | Hendersonville | Tennessee | 37075 | — |
| GSK Investigational Site | Knoxville | Tennessee | 37909 | — |
| GSK Investigational Site | Amarillo | Texas | 79106 | — |
| GSK Investigational Site | Amarillo | Texas | 79124 | — |
| GSK Investigational Site | Dallas | Texas | 75225 | — |
| GSK Investigational Site | Dallas | Texas | 75235 | — |
| GSK Investigational Site | Dallas | Texas | 75246 | — |
| GSK Investigational Site | Houston | Texas | 77030 | — |
| GSK Investigational Site | Houston | Texas | 77429 | — |
| GSK Investigational Site | Kerrville | Texas | 78028 | — |
| GSK Investigational Site | San Antonio | Texas | 78207 | — |
| GSK Investigational Site | San Antonio | Texas | 78229 | — |
| GSK Investigational Site | San Antonio | Texas | 78258 | — |
| GSK Investigational Site | Murray | Utah | 84107 | — |
| GSK Investigational Site | Richmond | Virginia | 23298 | — |
| GSK Investigational Site | Williamsburg | Virginia | 23188 | — |
| GSK Investigational Site | Bellingham | Washington | 98225 | — |
| GSK Investigational Site | Seattle | Washington | 98115 | — |
| GSK Investigational Site | Greenfield | Wisconsin | 53228 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 278 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04718389, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 18, 2026 · Synced Oct 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04718389 live on ClinicalTrials.gov.