A Phase 3 Study to Compare the Efficacy and Safety of HLX04-O with Ranibizumab in Subjects with WAMD
Public ClinicalTrials.gov record NCT04740671. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Double-masked, Active Controlled Study to Compare the Efficacy and Safety of HLX04-O Administered by Intravitreal Injection with Ranibizumab in Subjects with Wet Age-related Macular Degeneration (wAMD)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will compare the efficacy and safety of HLX04-O administered by intravitreal injection (IVT) with ranibizumab in patients with active wAMD.
Study identification
- NCT ID
- NCT04740671
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 410 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 50 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 1, 2021 (Actual)
- Primary completion
- Dec 31, 2024 (Actual)
- Completion
- Dec 31, 2024 (Actual)
- Last update posted
- Jan 3, 2025
2021 – 2024
United States locations
- U.S. sites
- 42
- U.S. states
- 18
- U.S. cities
- 37
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Associated Retina Consultants-Gilbert | Gilbert | Arizona | 85297 | — |
| Associated Retina Consultants-Phoenix | Phoenix | Arizona | 85020 | — |
| Retina Consultants of Orange County | Fullerton | California | 92835 | — |
| Global Research Management | Glendale | California | 91204 | — |
| Atlantis Eyecare, VMR Institute | Huntington Beach | California | 92647 | — |
| VMR Institute | Huntington Beach | California | 92647 | — |
| South Coast Retina Center | Long Beach | California | 90807 | — |
| Retina Consultants of Orange County | Los Alamitos | California | 90720 | — |
| MACRO Trials/ Lazar Retina | Los Angeles | California | 90048 | — |
| East West Eye Institute | Torrance | California | 90505 | — |
| Retina Consultants of Southern Colorado | Colorado Springs | Colorado | 80909 | — |
| Florida Retina Institute-Orlando | Jacksonville | Florida | 32216 | — |
| Florida Retina Institute-Orlando | Orlando | Florida | 32806 | — |
| University of South Florida | Tampa | Florida | 33612 | — |
| Center for Retina and Macular Disease | Winter Haven | Florida | 33880 | — |
| Southeast Retina Center | Augusta | Georgia | 30909 | — |
| The University of Chicago, IL | Chicago | Illinois | 60637 | — |
| The University of Chicago | Chicago | Illinois | 60637 | — |
| Illinois Retina Associates | Oak Park | Illinois | 60304 | — |
| Retina Associates LLC | Lenexa | Kansas | 66215 | — |
| Butchertown Clinical Trials | Louisville | Kentucky | 40206 | — |
| Cumberland Valley Retina Consultants | Hagerstown | Maryland | 21740 | — |
| Retina Consultants of Minnesota | Edina | Minnesota | 55435 | — |
| VitreoRetinal Surgery PLLC DBA Retina Consultants of Minnesota | Saint Louis Park | Minnesota | 55416 | — |
| Mississippi Retina Associates | Jackson | Mississippi | 39202 | — |
| Piedmont Retina Specialists | Asheville | North Carolina | 27103 | — |
| Western Carolina Retinal Associates | Asheville | North Carolina | 28803 | — |
| Graystone Eye | Hickory | North Carolina | 28602 | — |
| North Carolina Retina Associates | Wake Forest | North Carolina | 27332 | — |
| Verum Research, LLC | Eugene | Oregon | 97401 | — |
| Retina Consultants of Charleston - Beaufort | Beaufort | South Carolina | 29902 | — |
| Retina Consultants of Charleston: Charleston Neuroscience Institute | Charleston | South Carolina | 29414 | — |
| Carolina Center for Sight | Florence | South Carolina | 29501 | — |
| Retina Consultants of Nashville | Nashville | Tennessee | 37203 | — |
| Retina Consultants of TEXAS- Newcastle | Bellaire | Texas | 77401 | — |
| Mt. Olympus Research-Garcia | Houston | Texas | 77015 | — |
| Mt. Olympus Research/Museum Eye District | Houston | Texas | 77015 | — |
| Retina Consultants of TEXAS - Round Rock | Round Rock | Texas | 78681 | — |
| Retina Consultants of Texas | The Woodlands | Texas | 77384 | — |
| Retina Associates of Utah, PLLC | Salt Lake City | Utah | 84107 | — |
| Rocky Mountain Retina Consultants | Salt Lake City | Utah | 84107 | — |
| Emerson Clinical Research Institute | Falls Church | Virginia | 22042 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 84 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04740671, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jan 3, 2025 · Synced Oct 23, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04740671 live on ClinicalTrials.gov.