A Research Study to Compare a New Weekly Insulin, Insulin Icodec Used With DoseGuide App, and Daily Insulins in People With Type 2 Diabetes Who Have Not Used Insulin Before
Public ClinicalTrials.gov record NCT04760626. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Effectiveness and Safety of Once Weekly Insulin Icodec Used With DoseGuide Versus Once Daily Basal Insulin Analogues in an Insulin naïve Type 2 Diabetes Population in a Clinical Practice Setting
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study compares insulin icodec to different daily insulins in people with type 2 diabetes. The study will look at how well insulin icodec taken once weekly controls blood sugar compared to the insulins taken once daily. Participants will either get insulin icodec, that participants will have to inject once a week on the same day of the week, or a marketed insulin, that participants will have to inject once a day. Which treatment participants get is decided at random. The insulin is injected with a needle in a skin fold in the thigh, upper arm or stomach. Participants will measure their blood sugar every day. Participants will get a study phone to record safety data in the electronic diary (eDiary). If participants get a daily insulin they will record their insulin doses in the eDiary. If Participants get weekly insulin icodec, participants study phone will also have the DoseGuide App. The DoseGuide App gives dose recommendations based on their blood sugar and previous doses. Participants will record their insulin doses in the DoseGuide App. The study will last for about 1 year and 2 months. Participants will have 8 planned clinic visits with the study doctor. More visits will be planned to meet individual needs. At 6 clinic visits participants will have blood samples taken. Women cannot take part if pregnant, breast-feeding or plan to become pregnant during the study period.
Study identification
- NCT ID
- NCT04760626
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,085 participants
Conditions and interventions
Conditions
Interventions
- Insulin icodec Drug
- Insulin Glargine 100U/mL Drug
- Insulin Degludec Drug
- Insulin Glargine 300U/mL Drug
Drug
Eligibility (public fields only)
- Age range
- Not listed
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 1, 2021 (Actual)
- Primary completion
- Aug 12, 2022 (Actual)
- Completion
- Aug 29, 2022 (Actual)
- Last update posted
- Aug 11, 2026
2021 – 2022
United States locations
- U.S. sites
- 142
- U.S. states
- 40
- U.S. cities
- 125
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Univ of Alabama Birmingham | Birmingham | Alabama | 35233 | — |
| Lakeview Clinical Research, LLC | Guntersville | Alabama | 35976 | — |
| Pri Med Grp dba/Gil Ctr Fam | Gilbert | Arizona | 85296 | — |
| Lynn Institute of the Ozarks | Little Rock | Arkansas | 72204 | — |
| Anaheim Clinical Trials, LLC | Anaheim | California | 92801 | — |
| Advanced Clinical Research/Rancho Paseo Medical Group | Banning | California | 92220 | — |
| American Clinical Trials | Buena Park | California | 90620 | — |
| San Fernando Valley Hlth Inst, LLC | Canoga Park | California | 91304 | — |
| Med Center Medical Clinic | Carmichael | California | 95608 | — |
| Headlands Research California, LLC | Escondido | California | 92025 | — |
| Valley Research | Fresno | California | 93720 | — |
| Advanced Investigative Medicine, Inc. | Hawthorne | California | 90250 | — |
| Diabetes/Lipid Mgmt & Res Ctr | Huntington Beach | California | 92648 | — |
| Altman Clin & Trans Res Inst | La Jolla | California | 92037 | — |
| Scripps Whittier Diabetes Inst | La Jolla | California | 92037 | — |
| First Valley Medical Group | Lancaster | California | 93534 | — |
| Torrance Clin Res Inst, Inc. | Lomita | California | 90717 | — |
| Adventist Health White Memorial | Los Angeles | California | 90033 | — |
| Providence Clinical Research | North Hollywood | California | 91606 | — |
| Valley Clinical Trials, Inc. | Northridge | California | 91325 | — |
| Desert Oasis Hlthcr Med Group | Palm Springs | California | 92262 | — |
| Clinical Trials Research_Sacramento | Sacramento | California | 95821 | — |
| San Diego Family Care | San Diego | California | 92111 | — |
| NorCal Endocrinology and Internal Medicine | San Ramon | California | 94583 | — |
| Encompass Clinical Research_Spring Valley | Spring Valley | California | 91978 | — |
| Handelsman Yehuda | Tarzana | California | 91356-3551 | — |
| Diabetes Research Center | Tustin | California | 92780 | — |
| Coastal Metabolic Research Center | Ventura | California | 93003 | — |
| Denver Endocrinology Diabetes and Thyroid Center | Englewood | Colorado | 80113 | — |
| Chase Medical Research LLC | Waterbury | Connecticut | 06708 | — |
| MedStar Diabetes Institute | Washington D.C. | District of Columbia | 20010 | — |
| Clinical Res Of W Florida Inc | Clearwater | Florida | 33765 | — |
| Revival Research | Doral | Florida | 33122 | — |
| Est Cst Inst for Rsrch,Jksnvil | Jacksonville | Florida | 32216 | — |
| Jacksonville Ctr For Clin Res | Jacksonville | Florida | 32216 | — |
| University Of Miami | Miami | Florida | 33136 | — |
| Adult Medicine of Lake County, Inc | Mt. Dora | Florida | 32757 | — |
| Suncoast Clin Res Port Richey | New Port Richey | Florida | 34652 | — |
| Florida Institute for Clinical research | Orlando | Florida | 32825 | — |
| Palm Harbor Medical Associates | Palm Harbor | Florida | 34684-3609 | — |
| Suncoast Clinical Research, Inc. | Palm Harbor | Florida | 34684 | — |
| Metabolic Research Institute Inc | West Palm Beach | Florida | 33401 | — |
| Clinical Research of Cent FL | Winter Haven | Florida | 33880 | — |
| Emory University SOM | Atlanta | Georgia | 30303 | — |
| Atlanta Diabetes Associates | Atlanta | Georgia | 30318 | — |
| Atlanta VA Medical Center | Decatur | Georgia | 30033 | — |
| Physicians Research Assoc. LLC | Lawrenceville | Georgia | 30046 | — |
| Endo Res Solutions Inc | Roswell | Georgia | 30076 | — |
| Endo Res Solutions, Inc | Roswell | Georgia | 30076 | — |
| RNA America Health Sciences | Sugar Hill | Georgia | 30518 | — |
| East West Med Res Inst | Honolulu | Hawaii | 96814 | — |
| Elite Clinical Trials | Blackfoot | Idaho | 83221 | — |
| Cedar-Crosse Research Center | Chicago | Illinois | 60607 | — |
| Central Illinois Diabetes and Clinical Research | Springfield | Illinois | 62711 | — |
| American Health Network of Indiana, LLC_Avon_0 | Avon | Indiana | 46123 | — |
| Clinical Research Advantage, Inc.-Evansville | Evansville | Indiana | 47714 | — |
| Iowa Diab & Endo Res Center | West Des Moines | Iowa | 50266 | — |
| Cotton O'Neil Diab & Endo Ctr | Topeka | Kansas | 66606 | — |
| St Elizabeth Physicians Heart | Covington | Kentucky | 41011 | — |
| Four Rivers Clinical Research Inc | Paducah | Kentucky | 42001 | — |
| Ochsner Clinic Foundation | New Orleans | Louisiana | 70121 | — |
| MedStar Community Clin Res Ctr | Hyattsville | Maryland | 20782 | — |
| Endo and Metab Consultants | Rockville | Maryland | 20852 | — |
| MassResearch, LLC_Waltham | Waltham | Massachusetts | 02453 | — |
| Northern Pines Hlth Ctr, PC | Buckley | Michigan | 49620 | — |
| Arcturus Healthcare, PLC. | Troy | Michigan | 48098 | — |
| Diabetes & Endo Specialists Inc | Chesterfield | Missouri | 63017 | — |
| Jefferson City Medical Group, PC | Jefferson City | Missouri | 65109 | — |
| St Johns Health System | Springfield | Missouri | 65807-7304 | — |
| Rocky Mountain Health Network | Billings | Montana | 59102 | — |
| Methodist Physicians Clin | Omaha | Nebraska | 68114 | — |
| Univ of Nebraska Medical CTR | Omaha | Nebraska | 68198-3020 | — |
| Palm Research Center Inc-Vegas | Las Vegas | Nevada | 89148 | — |
| Southern New Hampshire Diabetes and Endocrinology | Nashua | New Hampshire | 03060 | — |
| Southern New Hampshire Diabete | Nashua | New Hampshire | 03060 | — |
| Albuquerque Clin Trials, Inc. | Albuquerque | New Mexico | 87102 | — |
| AMC Community Endocrinology | Albany | New York | 12203 | — |
| N.Y. Total Medical Care PC | Brooklyn | New York | 11215 | — |
| Northwell Health Div of Endo | Great Neck | New York | 11021 | — |
| Mid Hudson Medical Research, PLLC | New Windsor | New York | 12553 | — |
| CTSI Research Center | New York | New York | 10016 | — |
| Endocrine Associates of Long Island, PC | Smithtown | New York | 11787 | — |
| Staten Island Diabetes | Staten Island | New York | 10301-3914 | — |
| SUNY Upstate Medical University_Syracuse_0 | Syracuse | New York | 13131 | — |
| Southgate Medical Group, LLP | West Seneca | New York | 14224 | — |
| University of North Carolina | Chapel Hill | North Carolina | 27514 | — |
| PMG Research of Charlotte | Charlotte | North Carolina | 28209 | — |
| Physicians East Endocrinology | Greenville | North Carolina | 27834 | — |
| Medication Management, LLC | Raleigh | North Carolina | 27609 | — |
| Accellacare | Wilmington | North Carolina | 28401 | — |
| Ardmore Family Practice_Winston Salem | Winston-Salem | North Carolina | 27103 | — |
| Wake Forest School of Medicine | Winston-Salem | North Carolina | 27157 | — |
| Plains Clinical Research Center, LLC_Fargo | Fargo | North Dakota | 58104 | — |
| Diab & Endo Assoc of Stark Co | Canton | Ohio | 44718 | — |
| The Ohio State University Medical Center | Columbus | Ohio | 43203 | — |
| Providence Health Partners Ctr | Dayton | Ohio | 45439 | — |
| Prestige Clinical Research | Franklin | Ohio | 45005 | — |
| Your Diabetes Endocrine Nutrition Group, Inc. | Mentor | Ohio | 44060 | — |
| Clinical Research Source Inc | Perrysburg | Ohio | 43551 | — |
| New Venture Medical Research | Wadsworth | Ohio | 44281 | — |
| Intend Research | Norman | Oklahoma | 73069 | — |
| Oregon Health & Science University_Portland_0 | Portland | Oregon | 97239 | — |
| Heritage Valley Multispeciality Group Inc | Beaver | Pennsylvania | 15009 | — |
| Indiana-Armstrong Endocrinology Associates | Indiana | Pennsylvania | 15701 | — |
| Tristar Clin Investigations, PC | Philadelphia | Pennsylvania | 19114 | — |
| The Diabetes Center, LLC | Murrells Inlet | South Carolina | 29576 | — |
| Hillcrest Clinical Research | Simpsonville | South Carolina | 29681-1538 | — |
| Athens Medical Group | Athens | Tennessee | 37303 | — |
| AM Diabetes And Endocrinology Center | Bartlett | Tennessee | 38133 | — |
| Chattanooga Medical Research, LLC | Chattanooga | Tennessee | 37404 | — |
| Univ Diab & Endo Consultants | Chattanooga | Tennessee | 37411 | — |
| WR-ClinSearch, LLC | Chattanooga | Tennessee | 37421 | — |
| Holston Medical Group | Kingsport | Tennessee | 37660 | — |
| HealthStar Physicians PC | Morristown | Tennessee | 37813 | — |
| Amarillo Med Spec LLP | Amarillo | Texas | 79106 | — |
| Texas Diab & Endo, P.A. | Austin | Texas | 78731 | — |
| Texas Diabetes & Endocrinology | Austin | Texas | 78749 | — |
| Velocity Clinical Res-Dallas | Dallas | Texas | 75230 | — |
| North Texas Endocrine Center | Dallas | Texas | 75231 | — |
| UT Southwestern Med Cntr | Dallas | Texas | 75390-9302 | — |
| PrimeCare Medical Group | Houston | Texas | 77024 | — |
| Juno Research, LLC | Houston | Texas | 77074 | — |
| Endocrine And Psychiatry Center | Houston | Texas | 77095 | — |
| Protenium Clinical Research | Hurst | Texas | 76054 | — |
| Medical Colleagues-Texas LLP | Katy | Texas | 77450 | — |
| Fmc Science, Llc | Lampasas | Texas | 76550 | — |
| Andres Garcia-Zuniga, MD, P.A | Laredo | Texas | 78041 | — |
| Texas Diab & Endo, P.A. | Round Rock | Texas | 78681 | — |
| Clinical Trials of Texas, LLC | San Antonio | Texas | 78229 | — |
| NE Clin Res of San Antonio | San Antonio | Texas | 78233 | — |
| Simcare Medical Research, LLC | Sugar Land | Texas | 77478 | — |
| Elite Medical Care | Sugar Land | Texas | 77479 | — |
| Javara Inc. | The Woodlands | Texas | 77382 | — |
| Progressive Clinical Research UT | Bountiful | Utah | 84010 | — |
| Advanced Research Institute | Ogden | Utah | 84405 | — |
| Chrysalis Clinical Research | St. George | Utah | 84790 | — |
| Chatham Family Medical Center | Chatham | Virginia | 24531 | — |
| Danville Internal Medicine Inc | Danville | Virginia | 24541-2834 | — |
| TPMG Clinical Research | Newport News | Virginia | 23606 | — |
| Capital Clin Res Ctr,LLC | Olympia | Washington | 98502 | — |
| Rainier Clin Res Ctr Inc | Renton | Washington | 98057 | — |
| Clinical Investigation Specialists Inc, Kenosha | Kenosha | Wisconsin | 53144 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 169 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04760626, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 11, 2026 · Synced Oct 19, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04760626 live on ClinicalTrials.gov.