ClinicalTrials.gov record
Impella®-Supported PCI in High-Risk Patients With Complex Coronary Artery Disease and Reduced Left Ventricular Function
ClinicalTrials.gov ID: NCT04763200
Public ClinicalTrials.gov record NCT04763200. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Impella®-Supported PCI in High-Risk Patients With Complex Coronary Artery Disease and Reduced Left Ventricular Function: The PROTECT IV Trial
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to assess if using the Impella® CP (or Impella® 2.5) device during high-risk PCI in patients with reduced left-sided heart function will result in an improvement in symptoms, heart function and health after a heart procedure compared to the current standard of care.
Study identification
- NCT ID
- NCT04763200
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Not applicable
- Enrollment
- 1,252 participants
Conditions and interventions
Interventions
- Impella CP® / Impella CP® with SmartAssist® / Impella 2.5® Device
- IABP Intra-aortic balloon pump Device
Device
Eligibility (public fields only)
- Age range
- 18 Years to 90 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Apr 12, 2021
- Primary completion
- Sep 30, 2026
- Completion
- Sep 30, 2027
- Last update posted
- Jul 27, 2026
2021 – 2027
United States locations
- U.S. sites
- 83
- U.S. states
- 34
- U.S. cities
- 68
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama | Birmingham | Alabama | 35294 | — |
| St. Joseph's Medical Center - Phoenix | Phoenix | Arizona | 85016 | — |
| Northwest Medical Center Tucson | Tucson | Arizona | 85741 | — |
| Arkansas Cardiology | Little Rock | Arkansas | 72205 | — |
| Adventist Health Glendale | Glendale | California | 91206 | — |
| St. Joseph Hospital - Orange | Orange | California | 92868 | — |
| Loma Linda University Health | San Bernardino | California | 92354 | — |
| UCSD Medical Center | San Diego | California | 92093 | — |
| Colorado Heart and Vascular | Lakewood | Colorado | 80228 | — |
| Hartford Hospital | Hartford | Connecticut | 06106 | — |
| MedStar Washington Hospital Center | Washington D.C. | District of Columbia | 20010 | — |
| The Cardiac & Vascular Institute | Gainesville | Florida | 32605 | — |
| University of Florida Health - Gainesville | Gainesville | Florida | 32610 | — |
| UF Health Jacksonville | Jacksonville | Florida | 32209 | — |
| Emory University Hospital | Atlanta | Georgia | 30322 | — |
| Northside Cardiovascular Institute | Lawrenceville | Georgia | 30043 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| NorthShore University Health System | Evanston | Illinois | 60201 | — |
| Northwestern University | Evanston | Illinois | 60208 | — |
| Advocate Christ Medical Center | Oak Lawn | Illinois | 60453 | — |
| Cardiovascular Research Institute of Kansas | Wichita | Kansas | 67226 | — |
| Norton Healthcare - Norton Heart Specialists | Louisville | Kentucky | 40205 | — |
| Ochsner Foundation Hospital | New Orleans | Louisiana | 70121 | — |
| Tufts Medical Center | Boston | Massachusetts | 02111 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| Henry Ford St. John Hospital | Detroit | Michigan | 48236 | — |
| Corewell Health | Grand Rapids | Michigan | 49435 | — |
| Metropolitan Heart and Vascular Institute / Metropolitan Cardiology Consultants | Coon Rapids | Minnesota | 55433 | — |
| CentraCare (St. Cloud Hospital) | Saint Cloud | Minnesota | 56303 | — |
| SSM Health DePaul Hospital | Bridgeton | Missouri | 63044 | — |
| St. Luke's Hospital | Kansas City | Missouri | 64111 | — |
| Catholic Medical Center | Manchester | New Hampshire | 03102 | — |
| Englewood Hospital | Englewood | New Jersey | 07631 | — |
| Hackensack University Medical Center | Hackensack | New Jersey | 07601 | — |
| Morristown Medical Center | Morristown | New Jersey | 07960 | — |
| Jersey Shore University Medical Center | Neptune City | New Jersey | 07735 | — |
| The Valley Hospital - Ridgewood | Ridgewood | New Jersey | 07450 | — |
| Lovelace/New Mexico Heart Institute | Albuquerque | New Mexico | 87102 | — |
| University at Buffalo/Kaleida Health | Buffalo | New York | 14203 | — |
| Northwell University Hospital | Manhasset | New York | 11030 | — |
| NYU Langone Health | New York | New York | 10016 | — |
| Icahn School of Medicine at Mt. Sinai | New York | New York | 10029 | — |
| Columbia University Medical Cenrer/NYPH | New York | New York | 10032 | — |
| St. Francis Hospital and Heart Center | Roslyn | New York | 11576 | — |
| Stony Brook University Hospital (SUNY) | Stony Brook | New York | 11794 | — |
| Montefiore Medical Center - Moses | The Bronx | New York | 10467-2401 | — |
| Sanger Heart and Vascular Institute | Charlotte | North Carolina | 28204 | — |
| Duke University | Durham | North Carolina | 27710 | — |
| North Carolina Heart and Vascular Research | Raleigh | North Carolina | 27607 | — |
| Wake Forest University Health Sciences | Winston-Salem | North Carolina | 27157 | — |
| Linder Research Center (The Christ Hospital) | Cincinnati | Ohio | 45219 | — |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44106 | — |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| University of Oklahoma Medical Center | Oklahoma City | Oklahoma | 73104 | — |
| Providence St. Vincent Medical Center | Portland | Oregon | 97225 | — |
| Legacy Emanuel Hospital & Health Center | Portland | Oregon | 97232 | — |
| Lehigh Valley Health Network | Allentown | Pennsylvania | 18103 | — |
| Allegheny General Hospital | Pittsburgh | Pennsylvania | 15212 | — |
| WellSpan York Hospital | York | Pennsylvania | 17403 | — |
| Greenville Hospital System | Greenville | South Carolina | 29605 | — |
| Monument Health Clinical Research | Rapid City | South Dakota | 57701 | — |
| Wellmont Cardiology Services | Kingsport | Tennessee | 37660 | — |
| Parkwest Medical Center | Knoxville | Tennessee | 37923 | — |
| Centennial Heart - Nashville | Nashville | Tennessee | 37203 | — |
| Ascension St. Thomas West | Nashville | Tennessee | 37205 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | — |
| Presbyterian Hospital Dallas / Texas Health Physicians Group | Dallas | Texas | 75231 | — |
| Medical City Fort Worth | Fort Worth | Texas | 76104 | — |
| HCA Houston Healthcare | Houston | Texas | 77004 | — |
| Houston Methodist Hospital | Houston | Texas | 77030 | — |
| Memorial Hermann Texas Medical Center (UT Health) | Houston | Texas | 77030 | — |
| Texas Heart Institute at Baylor St. Luke's Hospital | Houston | Texas | 77030 | — |
| Texas Cardiology Associates of Houston | Kingwood | Texas | 77339 | — |
| Baylor Scott & White Heart - Plano | Plano | Texas | 75093 | — |
| Methodist Hospital - San Antonio | San Antonio | Texas | 78229 | — |
| Sentara Norfolk Health System | Norfolk | Virginia | 23507 | — |
| Carilion Clinic | Roanoke | Virginia | 24014 | — |
| University Of Washington Medical Center | Seattle | Washington | 98195 | — |
| West Virginia University Hospital | Morgantown | West Virginia | 26506 | — |
| Aurora St. Luke's Medical Center | Milwaukee | Wisconsin | 53215 | — |
| Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 27 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04763200, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 27, 2026 · Synced Sep 2, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04763200 live on ClinicalTrials.gov.