A Study to Investigate the Efficacy and Safety of NT 201 (Botulinum Toxin) Compared With Placebo for the Treatment of Adult Participants With Essential Tremor in the Arm
Public ClinicalTrials.gov record NCT04766723. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Prospective, Randomized, Double-blind, Placebo-controlled, Parallel-group Trial With an Open-label Period to Investigate the Efficacy and Safety of NT 201 in the Unilateral and Bilateral Treatment of Essential Tremor of the Upper Limb
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to determine whether a single treatment with NT 201 (botulinum toxin) is superior to placebo (no medicine) for one-sided treatment of essential tremor in the motor-dominant arm (Unilateral Period). Participants will be assigned to the treatment groups by chance and neither the participants nor the research staff who interact with them will know the allocation. The following treatment cycle will investigate the safety and tolerability of two-sided treatment with NT 201 (botulinum toxin) (Open Label Bilateral Period). All participants will receive NT 201 treatment.
Study identification
- NCT ID
- NCT04766723
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 78 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 23, 2021
- Primary completion
- Apr 25, 2023
- Completion
- Nov 20, 2023
- Last update posted
- May 27, 2026
2021 – 2023
United States locations
- U.S. sites
- 9
- U.S. states
- 8
- U.S. cities
- 9
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| USF, Department of Neurology, Merz Investigational Site #0010020 | Tampa | Florida | 33612 | — |
| University of Nebraska Medical Center, Merz Investigational Site #0010269 | Omaha | Nebraska | 68131 | — |
| Cleveland Clinic Lou Ruvo Center for Brain Health, Merz Investigational Site #0010457 | Las Vegas | Nevada | 89106 | — |
| Mount Sinai Medical Center, Merz Investigational Site #0010191 | New York | New York | 10029 | — |
| Vanderbilt University Medical Center, Neuroscience Institute, Merz Investigational Site #0010206 | Nashville | Tennessee | 37232 | — |
| Houston Methodist Neurological Institute, Merz Investigational Site #0010226 | Houston | Texas | 77030 | — |
| Medstar Georgetown Neurology, Merz Investigational Site #0010231 | McLean | Virginia | 22101 | — |
| UW Medical Center - Montlake, Merz Investigational Site #0010450 | Seattle | Washington | 98195 | — |
| Selkirk Neurology, Merz Investigational Site #0010456 | Spokane | Washington | 99202 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 5 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04766723, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 27, 2026 · Synced Sep 9, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04766723 live on ClinicalTrials.gov.