Study With ABBV-CLS-484 in Participants With Locally Advanced or Metastatic Tumors
Public ClinicalTrials.gov record NCT04777994. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 1 Study With ABBV-CLS-484 Alone and in Combination in Subjects With Locally Advanced or Metastatic Tumors
Study identification
- NCT ID
- NCT04777994
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 1
- Lead sponsor
- Calico Life Sciences LLC
- Industry
- Enrollment
- 248 participants
Conditions and interventions
Conditions
Interventions
- ABBV-CLS-484 Drug
- Programmed Cell Death-1 (PD-1) Inhibitor Drug
- Vascular Endothelial Growth Factor Receptor (VEGFR) Tyrosine Kinase Inhibitor (TKI) Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 8, 2021
- Primary completion
- Sep 30, 2026
- Completion
- Sep 30, 2026
- Last update posted
- Dec 22, 2025
2021 – 2026
United States locations
- U.S. sites
- 15
- U.S. states
- 10
- U.S. cities
- 14
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Arizona Cancer Center - Tucson /ID# 262698 | Tucson | Arizona | 85724 | Recruiting |
| Yale University School of Medicine /ID# 225707 | New Haven | Connecticut | 06510 | Recruiting |
| Johns Hopkins Hospital /ID# 254056 | Baltimore | Maryland | 21287 | Recruiting |
| Beth Israel Deaconess Medical Center /ID# 252009 | Boston | Massachusetts | 02215-5400 | Recruiting |
| Dana-Farber Cancer Institute /ID# 249642 | Boston | Massachusetts | 02215 | Recruiting |
| University of Michigan Comprehensive Cancer Center Michigan Medicine /ID# 252010 | Ann Arbor | Michigan | 48109 | Recruiting |
| NYU Laura and Isaac Perlmutter Cancer Center - 34th Street /ID# 257869 | New York | New York | 10016 | Recruiting |
| Duke Cancer Center /ID# 251975 | Durham | North Carolina | 27710 | Recruiting |
| Carolina BioOncology Institute /ID# 225704 | Huntersville | North Carolina | 28078 | Completed |
| Perelman Center for Advanced Medicine /ID# 250188 | Philadelphia | Pennsylvania | 19104 | Recruiting |
| UPMC Hillman Cancer Ctr /ID# 225706 | Pittsburgh | Pennsylvania | 15232 | Recruiting |
| Lifespan Cancer Institute at Rhode Island Hospital /ID# 225705 | Providence | Rhode Island | 02903-4923 | Recruiting |
| University of Texas Southwestern Medical Center /ID# 251974 | Dallas | Texas | 75390-7208 | Recruiting |
| University of Texas MD Anderson Cancer Center /ID# 252004 | Houston | Texas | 77030 | Recruiting |
| NEXT Oncology /ID# 225708 | San Antonio | Texas | 78229 | Completed |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 15 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04777994, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Dec 22, 2025 · Synced May 19, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04777994 live on ClinicalTrials.gov.