A Safety, Tolerability, and Efficacy Study of VX-880 in Participants With Type 1 Diabetes

ClinicalTrials.gov ID: NCT04786262

Public ClinicalTrials.gov record NCT04786262. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

View official ClinicalTrials.gov record → Back to search

ClinicalTrials.gov public records Last synced May 4, 2026, 8:26 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 1/2/3 Study to Evaluate the Safety, Tolerability, and Efficacy of VX-880 in Subjects Who Have Type 1 Diabetes Mellitus With Impaired Hypoglycemic Awareness and Severe Hypoglycemia

Study identification

NCT ID: NCT04786262
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Vertex Pharmaceuticals Incorporated; Industry
Enrollment: 52 participants

Conditions and interventions

Conditions

Interventions

VX-880 Biological

Biological

Eligibility (public fields only)

Age range: 18 Years to 65 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Mar 28, 2021
Primary completion: Jun 29, 2027
Completion: Jun 29, 2030
Last update posted: Mar 16, 2026

2021 – 2030

United States locations

U.S. sites: 12
U.S. states: 9
U.S. cities: 11

Facility	City	State	ZIP	Site status
City of Hope	Duarte	California	91010	Recruiting
University of California San Francisco	San Francisco	California	94143	Recruiting
UHealth Diabetes Research Institute	Miami	Florida	33136	Recruiting
Northwestern Organ Transplant Center	Chicago	Illinois	60611	Completed
University of Chicago	Chicago	Illinois	60637	Recruiting
Johns Hopkins University	Baltimore	Maryland	21287	Recruiting
Massachusetts General Hospital	Boston	Massachusetts	02114	Recruiting
Hospital of the University of Pennsylvania	Philadelphia	Pennsylvania	19104	Recruiting
University of Pittsburgh Medical Center Montefiore	Pittsburgh	Pennsylvania	15213	Recruiting
Baylor Scott and White Research Institute	Dallas	Texas	75246	Recruiting
VCU Medical Center, Richmond	Richmond	Virginia	23298	Recruiting
University of Wisconsin	Madison	Wisconsin	53792	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 17 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT04786262, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Mar 16, 2026 · Synced May 4, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT04786262 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →