Ultrasound-facilitated, Catheter-directed, Thrombolysis in Intermediate-high Risk Pulmonary Embolism
Public ClinicalTrials.gov record NCT04790370. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized Trial of Ultrasound-facilitated, Catheter-directed, Thrombolysis Versus Anticoagulation for Acute Intermediate-high Risk Pulmonary Embolism: The Higher-risk Pulmonary Embolism Thrombolysis Study
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
There are many available treatments for pulmonary embolism (PE), but the best treatment for this condition is not known. The HI-PEITHO study will compare two treatment options that are both available on the market for the treatment of PE. Patients will be randomized 1:1 to receive either blood thinners (anticoagulation) or blood thinners (anticoagulation) in combination with a device called the EkoSonicTM Endovascular device to dissolve blood clots. Patients will be followed for 12 months after randomization and have assessments while in the hospital as well as at 7 days, 30 days, 6 months and 12 months after randomization. The study will try to find out if one of these treatments is better than the other at reducing the risk of death and other serious problems.
Study identification
- NCT ID
- NCT04790370
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 4
- Enrollment
- 544 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 2, 2021 (Actual)
- Primary completion
- Jul 31, 2025 (Actual)
- Completion
- Aug 2026 (Estimated)
- Last update posted
- Jul 1, 2026
2021 – 2026
United States locations
- U.S. sites
- 28
- U.S. states
- 19
- U.S. cities
- 25
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35294 | — |
| Cedars - Sinai Medical Center | Los Angeles | California | 90048 | — |
| Christiana Hospital | Newark | Delaware | 19718 | — |
| Piedmont Hospital | Atlanta | Georgia | 30309 | — |
| Emory University Hospital | Atlanta | Georgia | 30322 | — |
| Augusta University | Augusta | Georgia | 30904 | — |
| Methodist Hospitals | Merrillville | Indiana | 46410 | — |
| Baptist Health East Louisville | Lousville | Kentucky | 40207 | — |
| University of Maryland School of Medicine | Baltimore | Maryland | 21201 | — |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | — |
| University of Michigan Hospitals | Ann Arbor | Michigan | 48109 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| North Mississippi Medical Center | Tupelo | Mississippi | 38801 | — |
| Nebraska Methodist Hospital | Omaha | Nebraska | 68114 | — |
| Dartmouth-Hitchcock Medical Center | Lebanon | New Hampshire | 03756 | — |
| Newark Beth Israel Medical Center | Newark | New Jersey | 07112 | — |
| Mount Sinai Medical Center | New York | New York | 10029 | — |
| Columbia University Medical Center | New York | New York | 10032 | — |
| Lenox Hill Hospital | New York | New York | 10075 | — |
| University Hospitals of Cleveland | Cleveland | Ohio | 44106 | — |
| Kettering Health | Kettering | Ohio | 45429 | — |
| Wellmont Holston Valley Medical Center | Kingsport | Tennessee | 37660 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | — |
| Seton Medical Center | Austin | Texas | 78705 | — |
| Houston Methodist Sugarland Hospital | Houston | Texas | 77479 | — |
| The Heart Hospital Baylor Plano | Plano | Texas | 75093 | — |
| University of Virginia Medical Center | Charlottesville | Virginia | 22908 | — |
| University of Wisconsin Hospitals | Madison | Wisconsin | 53792 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 32 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04790370, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 1, 2026 · Synced Oct 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04790370 live on ClinicalTrials.gov.