SPARK-ALL: Calaspargase Pegol in Adults With ALL
Public ClinicalTrials.gov record NCT04817761. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
SPARK-ALL: A Multi-center, Open-label, Single-arm Phase 2/3 Trial Evaluating the Safety and Pharmacokinetics of Calaspargase Pegol for Treatment of Adults Aged 22 To >65 Years With Newly-diagnosed Philadelphia-negative ALL.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this phase 2/3 study is to confirm the recommended doses and to evaluate the safety and pharmacodynamics of Calaspargase pegol for the treatment of adult patients with Philadelphia-negative Acute Lymphoblastic Leukemia.
Study identification
- NCT ID
- NCT04817761
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Enrollment
- 42 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 22 Years to 55 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 7, 2021 (Actual)
- Primary completion
- Mar 21, 2025 (Actual)
- Completion
- Mar 21, 2025 (Actual)
- Last update posted
- Feb 18, 2026
2021 – 2025
United States locations
- U.S. sites
- 21
- U.S. states
- 16
- U.S. cities
- 19
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| HonorHealth Cancer Transplant Institute | Scottsdale | Arizona | 85258 | — |
| City of Hope Comprehensive Cancer Center | Duarte | California | 91010 | — |
| Univeristy of California | Los Angeles | California | 90095 | — |
| University of California Irvine Health (UCI Health) | Orange | California | 92868 | — |
| University of Miami Health System - Sylvester Comprehensive Cancer Center | Miami | Florida | 33136 | — |
| University of Chicago Medicine | Chicago | Illinois | 60637 | — |
| University of Kansas Cancer Center - Richard and Annette Bloch Cancer Care Pavilion | Westwood | Kansas | 66205 | — |
| University of Maryland Greenbaum Cancer Center | Baltimore | Maryland | 21201 | — |
| Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Baltimore | Maryland | 21287 | — |
| Dana Farber Cancer Institute | Weymouth | Massachusetts | 02190 | — |
| Northwell Health Cancer Institute | Lake Success | New York | 11042 | — |
| NYU Langone/Laura and Isaac Perlmutter Cancer Center | New York | New York | 10016 | — |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | — |
| Duke University | Durham | North Carolina | 27705 | — |
| Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| Oregon Health & Science University (OHSU) | Portland | Oregon | 97239 | — |
| Jefferson Health | Philadelphia | Pennsylvania | 19107 | — |
| Baptist Clinical Research Institute | Memphis | Tennessee | 38120 | — |
| Intermountain Healthcare (IHC) | Salt Lake City | Utah | 84143 | — |
| University of Washington/Seattle Cancer Care Alliance/Fred Hutch | Seattle | Washington | 98109 | — |
| West Virginia University Cancer Institute | Morgantown | West Virginia | 26506 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04817761, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 18, 2026 · Synced Oct 22, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04817761 live on ClinicalTrials.gov.