Tivanisiran for Dry Eye in Subjects With Sjögren's Syndrome
Public ClinicalTrials.gov record NCT04819269. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will examine the efficacy and safety of tivanisiran sodium eye drops versus vehicle after a 2-week run-in phase when dosed once daily for 3 months in subjects with signs and symptoms of dry eye disease (DED) due to Sjögren's Syndrome.
Study identification
- NCT ID
- NCT04819269
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 203 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 25, 2021 (Actual)
- Primary completion
- Dec 11, 2023 (Actual)
- Completion
- Dec 11, 2023 (Actual)
- Last update posted
- Feb 20, 2024
2021 – 2023
United States locations
- U.S. sites
- 39
- U.S. states
- 18
- U.S. cities
- 38
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Sylentis Investigative Site | Birmingham | Alabama | 35294 | — |
| Sylentis Investigative Site | Dothan | Alabama | 36301 | — |
| Sylentis Investigative Site | Scottsdale | Arizona | 85254 | — |
| Sylentis Investigative Site | Garden Grove | California | 92843 | — |
| Sylentis Investigative Site | Glendale | California | 91204 | — |
| Sylentis Investigative Site | Los Angeles | California | 90013 | — |
| Sylentis Investigative Site | Newport Beach | California | 92663 | — |
| Sylentis Investigative Site | Rancho Cordova | California | 95670 | — |
| Sylentis Investigative Site | San Diego | California | 92122 | — |
| Sylentis Investigative Site | Torrance | California | 90505 | — |
| Sylentis Investigative Site | Aurora | Colorado | 80045 | — |
| Sylentis Investigative Site | Colorado Springs | Colorado | 80907 | — |
| Sylentis Investigative Site | Littleton | Colorado | 80120 | — |
| Sylentis Investigative Site | Jacksonville | Florida | 32256 | — |
| Sylentis Investigative Site | Largo | Florida | 33773 | — |
| Sylentis Investigative Site | Miami | Florida | 33136 | — |
| Sylentis Investigative Site | Ormond Beach | Florida | 32174 | — |
| Sylentis Investigative Site | Tampa | Florida | 33603 | — |
| Sylentis Investigative Site | Atlanta | Georgia | 30339 | — |
| Sylentis Investigative Site | Morrow | Georgia | 30260 | — |
| Sylentis Investigative Site | Carmel | Indiana | 46290 | — |
| Sylentis Investigative Site | Waltham | Massachusetts | 02451 | — |
| Sylentis Investigative Site | Ypsilanti | Michigan | 48197 | — |
| Sylentis Investigative Site | Kansas City | Missouri | 64111 | — |
| Sylentis Investigative Site | St Louis | Missouri | 63131 | — |
| Sylentis Investigative Site | Washington | Missouri | 63090 | — |
| Sylentis Investigative Site | Asheville | North Carolina | 28803 | — |
| Sylentis Investigative Site | High Point | North Carolina | 27262 | — |
| Sylentis Investigative Site | Fargo | North Dakota | 58103 | — |
| Sylentis Investigative Site | Cleveland | Ohio | 44115 | — |
| Sylentis Investigative Site | Columbus | Ohio | 43215 | — |
| Sylentis Investigative Site | Cranberry Township | Pennsylvania | 16066 | — |
| Sylentis Investigative Site | Rapid City | South Dakota | 57701 | — |
| Sylentis Investigative Site | Memphis | Tennessee | 38103 | — |
| Sylentis Investigative Site | Nashville | Tennessee | 37215 | — |
| Sylentis Investigative Site | El Paso | Texas | 79902 | — |
| Sylentis Investigative Site | Houston | Texas | 77030 | — |
| Sylentis Investigative Site | Houston | Texas | 77034 | — |
| Sylentis Investigative Site | Falls Church | Virginia | 22042 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 7 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04819269, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Feb 20, 2024 · Synced Oct 23, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04819269 live on ClinicalTrials.gov.