Study of Talazoparib With Enzalutamide in Men With DDR Gene Mutated mCSPC
Public ClinicalTrials.gov record NCT04821622. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
TALAPRO-3: A PHASE 3, RANDOMIZED, DOUBLE-BLIND, STUDY OF TALAZOPARIB WITH ENZALUTAMIDE VERSUS PLACEBO WITH ENZALUTAMIDE IN MEN WITH DDR GENE MUTATED METASTATIC CASTRATION-SENSITIVE PROSTATE CANCER
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of the study is to evaluate the safety and efficacy of talazoparib in combination with enzalutamide compared with placebo in combination with enzalutamide in participants with DDR-deficient mCSPC.
Study identification
- NCT ID
- NCT04821622
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 599 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Male
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 12, 2021 (Actual)
- Primary completion
- Feb 18, 2026 (Actual)
- Completion
- Aug 28, 2027 (Estimated)
- Last update posted
- Oct 13, 2026
2021 – 2027
United States locations
- U.S. sites
- 45
- U.S. states
- 18
- U.S. cities
- 29
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham | Birmingham | Alabama | 35233 | — |
| University of Alabama at Birmingham | Birmingham | Alabama | 35249 | — |
| Arizona Institute of Urology, PLLC | Tucson | Arizona | 85704 | — |
| Beverly Hills Cancer Center | Beverly Hills | California | 90211 | — |
| Adventist Health Glendale | Glendale | California | 91206 | — |
| VA Long Beach Healthcare System | Long Beach | California | 90822 | — |
| Yale-New Haven Hospital | New Haven | Connecticut | 06510 | — |
| MedStar Georgetown University Hospital | Washington D.C. | District of Columbia | 20007 | — |
| Washington Cancer Institute at MedStar Washington Hospital Center | Washington D.C. | District of Columbia | 20010 | — |
| AdventHealth Medical Group Hematology and Oncology | Orlando | Florida | 32804 | — |
| Investigational Drug Services, Advent Health Orlando | Orlando | Florida | 32804 | — |
| Northwest Georgia Oncology Centers, a Service of WellStar Cobb Hospital | Austell | Georgia | 30106 | — |
| Wellstar Cobb Hospital | Austell | Georgia | 30106 | — |
| Northwest Georgia Oncology Centers, a Service of Tanner Medical Center Villa Rica | Carrollton | Georgia | 30117 | — |
| West Georgia Infusion Center, a Service of Tanner Medical Center Villa Rica | Carrollton | Georgia | 30117 | — |
| Northwest Georgia Oncology Centers, a Service of WellStar Cobb Hospital | Cartersville | Georgia | 30121 | — |
| Northwest Georgia Oncology Centers, a Service of WellStar Cobb Hospital | Douglasville | Georgia | 30134 | — |
| Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital | Marietta | Georgia | 30060 | — |
| Comprehensive Urologic Care, SC | Lake Barrington | Illinois | 60010 | — |
| Mid-Illinois Hematology & Oncology Associates, Ltd | Normal | Illinois | 61761 | — |
| Henry Ford Health System | Detroit | Michigan | 48202 | — |
| Henry Ford Medical Center - New Center One | Detroit | Michigan | 48202 | — |
| Revive Research Institute, Inc. | Farmington Hills | Michigan | 48334 | — |
| David C. Pratt Cancer Center | St Louis | Missouri | 63141 | — |
| New Jersey Cancer Care, P.A. | Belleville | New Jersey | 07109 | — |
| Premier Medical Group of the Hudson Valley PC | Poughkeepsie | New York | 12603 | — |
| Providence Cancer Institute Franz Clinic | Portland | Oregon | 97213 | — |
| Providence Portland Medical Center | Portland | Oregon | 97213 | — |
| Keystone Urology Specialists | Lancaster | Pennsylvania | 17604 | — |
| Carolina Urologic Research Center, LLC | Myrtle Beach | South Carolina | 29572 | — |
| Bristol Regional Medical Center | Bristol | Tennessee | 37620 | — |
| Ballad Health Cancer Care - Kingsport | Kingsport | Tennessee | 37660 | — |
| Holston Valley Hospital and Medical Center | Kingsport | Tennessee | 37660 | — |
| Indian Path Community Hospital | Kingsport | Tennessee | 37660 | — |
| Kelsey Research Foundation | Houston | Texas | 77005 | — |
| Oncology Consultants, P.A. | Houston | Texas | 77008 | — |
| Kelsey-Seybold Clinic | Houston | Texas | 77014 | — |
| oncology Consultants, P.A. | Houston | Texas | 77024 | — |
| Kelsey-Seybold Clinic | Houston | Texas | 77025 | — |
| Houston Metro Urology | Houston | Texas | 77027 | — |
| Oncology Consultants P.A. | Houston | Texas | 77030 | — |
| Kelsey-Seybold Clinic | Houston | Texas | 77055 | — |
| Urology San Antonio | San Antonio | Texas | 78229 | — |
| Texas Oncology-Deke Slayton Cancer Center | Webster | Texas | 77598 | — |
| Huntsman Cancer Institute - University of Utah | Salt Lake City | Utah | 84112 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 267 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04821622, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 13, 2026 · Synced Oct 17, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04821622 live on ClinicalTrials.gov.