A Clinical Trial Evaluating the Safety and Efficacy of a Single Subretinal Injection of AGTC-501 in Participants With XLRP
Public ClinicalTrials.gov record NCT04850118. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Controlled, Masked, Multi-center Study Evaluating the Efficacy, Safety, and Tolerability of Two Doses of AGTC-501 Compared to an Untreated Control Group in Male Participants With X-linked Retinitis Pigmentosa
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will evaluate and compare the safety, efficacy, and tolerability of 2 doses of a recombinant adeno-associated virus vector (AGTC-501/laruparetigene zovaparvovec )) to an untreated control group in male participants with X-linked retinitis pigmentosa caused by RPGR mutations.
Study identification
- NCT ID
- NCT04850118
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Enrollment
- 85 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 12 Years to 50 Years
- Sex
- Male
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Mar 14, 2024 (Actual)
- Primary completion
- Jun 30, 2026 (Estimated)
- Completion
- Oct 31, 2031 (Estimated)
- Last update posted
- Apr 7, 2026
2024 – 2031
United States locations
- U.S. sites
- 19
- U.S. states
- 12
- U.S. cities
- 18
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Retina Macula Institute of Arizona | Scottsdale | Arizona | 85255 | — |
| Children's Hospital Los Angeles | Los Angeles | California | 90027 | — |
| University of Florida Health Jacksonville, Department of Ophthalmology | Jacksonville | Florida | 32209 | — |
| Bascom Palmer Eye Institute- University of Miami | Miami | Florida | 33136 | — |
| Midwest Eye Institute (Retina Partners Midwest) | Carmel | Indiana | 46290 | — |
| Wilmer Eye Institute at Johns Hopkins | Baltimore | Maryland | 21287 | — |
| Ophthalmic Consultants of Boston | Boston | Massachusetts | 02114 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| Duke Eye Center | Durham | North Carolina | 27710 | — |
| Cincinnati Eye Institute | Cincinnati | Ohio | 45242 | — |
| Cole Eye Institute - Cleveland Clinic | Cleveland | Ohio | 44195 | — |
| Casey Eye Institute, OHSU | Portland | Oregon | 97239 | — |
| The Center for Advanced Retinal & Ocular Therapeutics University of Pennsylvania Perelman School of Medicine | Philadelphia | Pennsylvania | 19104 | — |
| Mid Atlantic Retina | Philadelphia | Pennsylvania | 19107 | — |
| University of Pittsburgh | Pittsburgh | Pennsylvania | 15219 | — |
| Retina Consultants of Texas | Bellaire | Texas | 77401 | — |
| Retina Foundation of the Southwest | Dallas | Texas | 75231 | — |
| Baylor Eye Institute | Houston | Texas | 77030 | — |
| Retina Consultants of San Antonio Texas | San Antonio | Texas | 78240 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 6 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04850118, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 7, 2026 · Synced Oct 29, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04850118 live on ClinicalTrials.gov.