Dipraglurant (ADX48621) for the Treatment of Patients With Parkinson's Disease Receiving Levodopa-based Therapy
Public ClinicalTrials.gov record NCT04857359. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Phase 2b/3, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of Dipraglurant (ADX48621) for the Treatment of Dyskinesia in Patients With Parkinson's Disease Receiving Levodopa-based Therapy
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study is designed to evaluate the safety and efficacy of dipraglurant in PD patients with dyskinesia (randomized 1:1 to receive active or placebo) for 12 weeks (1 week at 150 mg per day and 11 weeks at 300 mg per day). The primary efficacy assessment will be based on the Unified Dyskinesia Rating Scale (UDysRS). Patients who complete the 12-week blinded treatment period may have the option to roll into an open-label safety extension study for an additional 12-month treatment period.
Study identification
- NCT ID
- NCT04857359
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Enrollment
- 25 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 30 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 6, 2021 (Actual)
- Primary completion
- Jun 17, 2022 (Actual)
- Completion
- Aug 15, 2022 (Actual)
- Last update posted
- Aug 6, 2025
2021 – 2022
United States locations
- U.S. sites
- 41
- U.S. states
- 21
- U.S. cities
- 41
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Xenosciences Inc | Phoenix | Arizona | 85004 | — |
| Neuro-Pain Medical Center | Fresno | California | 93710 | — |
| University of California Irvine Medical Center | Irvine | California | 92697 | — |
| Stanford Neuroscience Health Center | Palo Alto | California | 94304 | — |
| Pacific Neuroscience Institute | Torrance | California | 90503 | — |
| Rocky Mountain Movement Disorders Center | Englewood | Colorado | 80113 | — |
| Chase Family Movement Disorders Center - Vernon | Vernon | Connecticut | 06066 | — |
| Parkinson's Disease and Movement Disorders Center of Boca Raton Inc | Boca Raton | Florida | 33486 | — |
| Renstar Medical Research -21 NE 1st Ave | Ocala | Florida | 34471 | — |
| AES - DRS - Synexus Clinical Research US, Inc. - Orlando | Orlando | Florida | 32806 | — |
| Neurology Associates of Ormond Beach | Ormond Beach | Florida | 32174 | — |
| Suncoast Neuroscience Associates Inc | St. Petersburg | Florida | 33712 | — |
| University of South Florida | Tampa | Florida | 33612-4799 | — |
| Geodyssey Research LLC | Vero Beach | Florida | 32960 | — |
| Emory University | Atlanta | Georgia | 30329 | — |
| Augusta University | Augusta | Georgia | 30912 | — |
| NeuroStudies.net, LLC - ClinEdge - PPDS | Decatur | Georgia | 30033 | — |
| Rush University Medical Center | Chicago | Illinois | 60612 | — |
| Southern Illinois University School of Medicine | Springfield | Illinois | 62702 | — |
| Josephson Wallack Munshower Neurology PC | Indianapolis | Indiana | 46256 | — |
| University of Kansas Medical Center | Kansas City | Kansas | 66160 | — |
| Henry Ford Health System | Bingham Farms | Michigan | 48025-4334 | — |
| Michigan State University | East Lansing | Michigan | 48824 | — |
| Cooper University Hospital | Camden | New Jersey | 08103 | — |
| Rutgers, the State University of New Jersey | New Brunswick | New Jersey | 08901 | — |
| University of New Mexico Health Sciences Center | Albuquerque | New Mexico | 87106-2719 | — |
| David L Kreitzman MD PC | Commack | New York | 11725 | — |
| Icahn School of Medicine at Mount Sinai | New York | New York | 10029 | — |
| The Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | — |
| The Ohio State University Wexner Medical Center | Columbus | Ohio | 43210-1267 | — |
| University of Toledo, Gardner-McMaster Parkinson Center | Toledo | Ohio | 43614 | — |
| Abington Neurologic Associates | Abington | Pennsylvania | 19001-3816 | — |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19107 | — |
| Avera Medical Group | Sioux Falls | South Dakota | 57105 | — |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | — |
| UT Health Science Center, San Antonio | San Antonio | Texas | 78229-3901 | — |
| Meridian Clinical Research (Norfolk, Virginia) | Norfolk | Virginia | 23502-3932 | — |
| Sentara Neurology Specialists | Virginia Beach | Virginia | 23456 | — |
| Evergreen Hospital Medical Center | Kirkland | Washington | 98034 | — |
| University of Wisconsin Hospitals and Clinics | Madison | Wisconsin | 53705 | — |
| Froedtert and The Medical College of Wisconsin | Milwaukee | Wisconsin | 53226-0509 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04857359, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 6, 2025 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04857359 live on ClinicalTrials.gov.