Capivasertib + CDK4/6i + Fulvestrant for Advanced/Metastatic HR+/HER2- Breast Cancer (CAPItello-292)

ClinicalTrials.gov ID: NCT04862663

Public ClinicalTrials.gov record NCT04862663. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 5, 2026, 9:29 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase Ib/III, Open-label, Randomised Study of Capivasertib Plus CDK4/6 Inhibitors and Fulvestrant Versus CDK4/6 Inhibitors and Fulvestrant in Hormone Receptor-Positive and Human Epidermal Growth Factor Receptor 2-Negative Locally Advanced, Unresectable or Metastatic Breast Cancer (CAPItello-292)

Study identification

NCT ID: NCT04862663
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: AstraZeneca; Industry
Enrollment: 895 participants

Conditions and interventions

Conditions

Locally Advanced (Inoperable) or Metastatic Breast Cancer

Interventions

Abemaciclib Drug
Capivasertib Drug
Fulvestrant Drug
Palbociclib Drug
Ribociclib Drug

Drug

Eligibility (public fields only)

Age range: 18 Years to 99 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: May 9, 2021
Primary completion: Oct 31, 2027
Completion: Aug 13, 2029
Last update posted: Apr 19, 2026

2021 – 2029

United States locations

U.S. sites: 52
U.S. states: 26
U.S. cities: 48

Facility	City	State	ZIP	Site status
Research Site	Tucson	Arizona	85719	Recruiting
Research Site	Fountain Valley	California	92708	Recruiting
Research Site	Glendale	California	91204	Recruiting
Research Site	Los Angeles	California	90033	Recruiting
Research Site	Los Angeles	California	90048	Withdrawn
Research Site	Napa	California	94558	Recruiting
Research Site	Newport Beach	California	92663	Suspended
Research Site	San Francisco	California	94158	Recruiting
Research Site	Santa Barbara	California	93105	Withdrawn
Research Site	Santa Rosa	California	92805	Recruiting
Research Site	Aurora	Colorado	80045	Recruiting
Research Site	New Haven	Connecticut	06510	Recruiting
Research Site	Newark	Delaware	19713	Recruiting
Research Site	Quincy	Illinois	62305	Suspended
Research Site	Fort Wayne	Indiana	46804	Withdrawn
Research Site	Louisville	Kentucky	40202	Recruiting
Research Site	Baton Rouge	Louisiana	70809	Withdrawn
Research Site	Covington	Louisiana	70433	Withdrawn
Research Site	Annapolis	Maryland	21401	Recruiting
Research Site	Baltimore	Maryland	21202	Withdrawn
Research Site	Baltimore	Maryland	21229	Withdrawn
Research Site	Boston	Massachusetts	02215	Active, not recruiting
Research Site	Detroit	Michigan	48236	Recruiting
Research Site	Grand Rapids	Michigan	49503	Recruiting
Research Site	Hannibal	Missouri	63401	Recruiting
Research Site	St Louis	Missouri	63110	Recruiting
Research Site	Omaha	Nebraska	68130	Recruiting
Research Site	Camden	New Jersey	08103	Recruiting
Research Site	Brooklyn	New York	11220	Withdrawn
Research Site	Mineola	New York	11501	Completed
Research Site	New York	New York	10016	Completed
Research Site	New York	New York	10065	Recruiting
Research Site	Durham	North Carolina	27710	Withdrawn
Research Site	Gresham	Oregon	97030	Recruiting
Research Site	Philadelphia	Pennsylvania	19104	Terminated
Research Site	Pittsburgh	Pennsylvania	15213	Recruiting
Research Site	York	Pennsylvania	17403	Terminated
Research Site	Providence	Rhode Island	02903	Withdrawn
Research Site	Greenville	South Carolina	29607	Terminated
Research Site	Chattanooga	Tennessee	37404	Recruiting
Research Site	Nashville	Tennessee	37203	Recruiting
Research Site	Dallas	Texas	75246	Recruiting
Research Site	Fort Worth	Texas	76104	Withdrawn
Research Site	Houston	Texas	77030	Recruiting
Research Site	San Antonio	Texas	78229	Recruiting
Research Site	San Antonio	Texas	78240	Recruiting
Research Site	Salt Lake City	Utah	84106	Recruiting
Research Site	Fairfax	Virginia	22031	Recruiting
Research Site	Falls Church	Virginia	22042	Completed
Research Site	Midlothian	Virginia	23114	Recruiting
Research Site	Norfolk	Virginia	23502	Recruiting
Research Site	Tacoma	Washington	98405	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 226 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT04862663, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 19, 2026 · Synced May 5, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT04862663 live on ClinicalTrials.gov.

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