JNJ-90301900 (NBTXR3) Activated by Radiotherapy With or Without Cetuximab in LA-HNSCC

ClinicalTrials.gov ID: NCT04892173

Public ClinicalTrials.gov record NCT04892173. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 8, 2026, 3:55 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3 Study of NBTXR3 Activated by Investigator's Choice of Radiotherapy Alone or Radiotherapy in Combination With Cetuximab for Platinum-based Chemotherapy-Ineligible Elderly Patients With Locally Advanced Head & Neck Squamous Cell Carcinoma

Study identification

NCT ID: NCT04892173
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Johnson & Johnson Enterprise Innovation Inc.; Industry
Enrollment: 500 participants

Conditions and interventions

Conditions

Carcinoma, Squamous Cell

Interventions

Cetuximab Drug
JNJ-90301900 (NBTXR3) Drug
Radiation Therapy Radiation

Drug · Radiation

Eligibility (public fields only)

Age range: 60 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Dec 9, 2021
Primary completion: Jun 29, 2028
Completion: Jun 29, 2028
Last update posted: Apr 26, 2026

2021 – 2028

United States locations

U.S. sites: 26
U.S. states: 15
U.S. cities: 26

Facility	City	State	ZIP	Site status
University of Alabama at Birmingham	Birmingham	Alabama	35294	Recruiting
City of Hope	Duarte	California	91010	Recruiting
University of California at San Diego Moores Cancer Center	La Jolla	California	92093	Recruiting
Memorial Radiation Oncology Medical Group Laguna Hills	Laguna Hills	California	92653	Completed
UCLA Hematology Oncology	Los Angeles	California	90095	Recruiting
Hoag Memorial Hospital	Newport Beach	California	92663	Recruiting
University of California San Francisco	San Francisco	California	94158	Recruiting
George Washington University Cancer Center	Washington D.C.	District of Columbia	20052	Recruiting
Mayo Clinic Jacksonville	Jacksonville	Florida	32224	Recruiting
AdventHealth Orlando	Orlando	Florida	32803	Recruiting
Moffitt Cancer Center	Tampa	Florida	33612	Recruiting
Emory University Hospital Midtown	Atlanta	Georgia	30308	Recruiting
University of Kentucky Markey Cancer Center	Lexington	Kentucky	40536	Recruiting
Boston Medical Center	Boston	Massachusetts	02118	Recruiting
Christus St. Vincent Regional Cancer Center	Santa Fe	New Mexico	87505	Completed
Herbert Irving Comprehensive Cancer Center Columbia University Medical Center	New York	New York	10032	Completed
Richmond University Medical Center	Staten Island	New York	10310	Recruiting
Montefiore Medical Center	The Bronx	New York	10467	Recruiting
University of North Carolina at Chapel Hill	Chapel Hill	North Carolina	27514	Recruiting
Atrium Health Levine Cancer Institute	Charlotte	North Carolina	28204	Recruiting
University of Cincinnati	Cincinnati	Ohio	45219	Recruiting
Stephenson Cancer Center	Oklahoma City	Oklahoma	73104	Recruiting
Oregon Health And Science University	Portland	Oregon	97239	Recruiting
University of Pennsylvania Perelman Center for Advanced Medicine	Philadelphia	Pennsylvania	19104	Recruiting
University of Virginia	Charlottesville	Virginia	22908	Recruiting
Macon Joan Brock Virginia Health Sciences Eastern Virginia Medical Group at Old Dominion University	Norfolk	Virginia	23507	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 164 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT04892173, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 26, 2026 · Synced May 8, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT04892173 live on ClinicalTrials.gov.

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