ClinicalTrials.gov record
ATEMPT 2.0: Adjuvant T-DM1 vs TH
ClinicalTrials.gov ID: NCT04893109
Public ClinicalTrials.gov record NCT04893109. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced Apr 29, 2026, 10:35 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized Phase II Trial of Adjuvant Trastuzumab Emtansine (T-DM1) Followed by Subcutaneous Trastuzumab Versus Paclitaxel in Combination With Subcutaneous Trastuzumab for Stage I HER2-positive Breast Cancer (ATEMPT 2.0)
Study identification
- NCT ID
- NCT04893109
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Dana-Farber Cancer Institute
- Other
- Enrollment
- 500 participants
Conditions and interventions
Conditions
Interventions
- Paclitaxel Drug
- Trastuzumab SC Drug
- trastuzumab-emtansine Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 15, 2021
- Primary completion
- Oct 31, 2026
- Completion
- Apr 30, 2028
- Last update posted
- Apr 23, 2026
2021 – 2028
United States locations
- U.S. sites
- 53
- U.S. states
- 15
- U.S. cities
- 47
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| UCSF Helen Diller Family Comprehensive Cancer Center | San Francisco | California | 94158 | Recruiting |
| Smilow Cancer Hospital Care center at Derby | Derby | Connecticut | 06418 | Recruiting |
| Smilow Cancer Hospital Care center at Fairfield | Fairfield | Connecticut | 06824 | Recruiting |
| Smilow Cancer Hospital Care center at Glastonbury | Glastonbury | Connecticut | 06033 | Recruiting |
| Smilow Cancer Hospital Care center at Greenwich | Greenwich | Connecticut | 06830 | Recruiting |
| Smilow Cancer Hospital Care center at Guilford | Guilford | Connecticut | 06437 | Recruiting |
| Smilow Cancer Hospital Care center at St. Francis | Hartford | Connecticut | 06105 | Recruiting |
| Smilow Cancer Hospital Care center at Long Ridge | Long Ridge | Connecticut | 06902 | Recruiting |
| Yale Cancer Center at Yale University School of Medicine | New Haven | Connecticut | 06520-8028 | Recruiting |
| Smilow Cancer Hospital Care center at North Haven | North Haven | Connecticut | 06510 | Recruiting |
| Stamford Hospital | Stamford | Connecticut | 06904 | Recruiting |
| Smilow Cancer Hospital Care center at Torrington | Torrington | Connecticut | 06790 | Recruiting |
| Smilow Cancer Hospital Care center at Trumbull | Trumbull | Connecticut | 06611 | Recruiting |
| Smilow Cancer Hospital Care center at Waterbury | Waterbury | Connecticut | 06708 | Recruiting |
| Smilow Cancer Hospital Care center at Waterford | Waterford | Connecticut | 06385 | Recruiting |
| Miami Cancer Institute/Baptist Hospital of Miami | Miami | Florida | 33176 | Recruiting |
| Miami Cancer Institute - Plantation (MCIP) | Plantation | Florida | 33324 | Recruiting |
| The University of Chicago Medical Center | Chicago | Illinois | 60637 | Recruiting |
| Indiana University Health Joe & Shelly Schwarz Cancer Center | Carmel | Indiana | 46032 | Active, not recruiting |
| IU Health North Hospital | Carmel | Indiana | 46032 | Active, not recruiting |
| Indiana University Melvin and Bren Simon Comprehensive Cancer Center | Indianapolis | Indiana | 46202 | Active, not recruiting |
| Indiana University Sidney and Lois Eskenazi Hospital | Indianapolis | Indiana | 46202 | Active, not recruiting |
| Eastern Maine Medical Center (Northern Light) | Brewer | Maine | 04412 | Recruiting |
| New England Cancer Specialists | Scarborough | Maine | 04074 | Recruiting |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | Recruiting |
| Dana Farber Cancer Institute | Boston | Massachusetts | 02215 | Recruiting |
| Massachusetts General Hospital | Boston | Massachusetts | 02215 | Recruiting |
| Dana-Farber at St. Elizabeth's Medical Center | Brighton | Massachusetts | 02135 | Recruiting |
| Lahey Clinic | Burlington | Massachusetts | 01805 | Recruiting |
| Mass General North Shore Cancer Center | Danvers | Massachusetts | 01923 | Recruiting |
| Dana-Farber Brigham Cancer Center - Foxborough | Foxborough | Massachusetts | 02035 | Recruiting |
| Dana-Farber Cancer Instiute - Merrimack Valley | Methuen | Massachusetts | 01844 | Recruiting |
| Dana-Farber at Milford | Milford | Massachusetts | 01757 | Recruiting |
| Newton Wellesley Hospital | Newton | Massachusetts | 02462 | Recruiting |
| Berkshire Medical Center | Pittsfield | Massachusetts | 01201 | Recruiting |
| Dana Farber at South Shore Hospital | Weymouth | Massachusetts | 02190 | Recruiting |
| NH Oncology-Hematology, PA - Payson Center for Cancer Care | Concord | New Hampshire | 03301 | Recruiting |
| Dana-Farber Cancer Insitute at Londonderry Hospital | Londonderry | New Hampshire | 03053 | Recruiting |
| Solinsky Center for Cancer Care (NH Oncology-Hematology, PA) | Manchester | New Hampshire | 03103 | Recruiting |
| New England Cancer Specialists - Portsmouth | Portsmouth | New Hampshire | 03801 | Recruiting |
| New York University Langone Hospital -Brooklyn | Brooklyn | New York | 11220 | Recruiting |
| New York University Langone Hospital - Long Island | Mineola | New York | 11501 | Recruiting |
| New York University Langone Health | New York | New York | 10016 | Recruiting |
| Northwell University | New York | New York | 10075 | Recruiting |
| Duke University Medical Center | Durham | North Carolina | 27710 | Active, not recruiting |
| Duke Women's Cancer Care Raleigh | Raleigh | North Carolina | 27710 | Active, not recruiting |
| Stefanie Spielman Comprehensive Breast Center | Columbus | Ohio | 43212 | Recruiting |
| University of Pennsylvania, Abramson Cancer Center | Philadelphia | Pennsylvania | 19104 | Recruiting |
| University of Pittsburgh Medical Center Cancer UPMC- Magee Women's Hospital | Pittsburgh | Pennsylvania | 15213 | Recruiting |
| Smilow Cancer Hospital Care center at Westerly | Westerly | Rhode Island | 02891 | Recruiting |
| Greco-Hainsworth Centers for Research/Tennessee Oncology | Nashville | Tennessee | 37203 | Recruiting |
| SCRI Oncology Partners | Nashville | Tennessee | 37203 | Recruiting |
| MD Anderson Cancer Center | Houston | Texas | 77030 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04893109, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 23, 2026 · Synced Apr 29, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04893109 live on ClinicalTrials.gov.