ClinicalTrials.gov record
A Study of Vaccination With 9-valent Extraintestinal Pathogenic Escherichia Coli Vaccine (ExPEC9V) in the Prevention of Invasive Extraintestinal Pathogenic Escherichia Coli Disease in Adults Aged 60 Years And Older With a History of Urinary Tract Infection in the Past 2 Years
ClinicalTrials.gov ID: NCT04899336
Public ClinicalTrials.gov record NCT04899336. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Randomized, Double-blind, Placebo-controlled, Multicenter Phase 3 Study to Assess the Efficacy, Safety And Immunogenicity of Vaccination With ExPEC9V in the Prevention of Invasive Extraintestinal Pathogenic Escherichia Coli Disease in Adults Aged 60 Years And Older With a History of Urinary Tract Infection in the Past 2 Years
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to demonstrate the efficacy of 9-valent extraintestinal pathogenic Escherichia coli vaccine (ExPEC9V) compared to placebo in the prevention of the first invasive extraintestinal pathogenic Escherichia coli disease (IED) event caused by ExPEC9V O-serotypes.
Study identification
- NCT ID
- NCT04899336
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 17,797 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 60 Years and older
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 30, 2021 (Actual)
- Primary completion
- Aug 27, 2025 (Actual)
- Completion
- Aug 27, 2025 (Actual)
- Last update posted
- Sep 28, 2026
2021 – 2025
United States locations
- U.S. sites
- 142
- U.S. states
- 33
- U.S. cities
- 103
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Lakeview Clinical Research | Guntersville | Alabama | 35976 | — |
| Hope Research Institute | Phoenix | Arizona | 85018 | — |
| Hope Research Institute | Phoenix | Arizona | 85108 | — |
| Interspond-Clinical Research Institute of AZ | Sun City West | Arizona | 85357 | — |
| Baptist Health Center For Clinical Research | Little Rock | Arkansas | 72205 | — |
| Sun Urology - Buena Park Office | Buena Park | California | 90621 | — |
| Hope clinical Research LLC | Canoga Park | California | 91303 | — |
| Velocity Clinical Research, Inc. | Chula Vista | California | 91911 | — |
| Marvel Clinical Research | Huntington Beach | California | 92647 | — |
| California Adult Circumcision - Alvarado La Mesa Urology Center | La Mesa | California | 91942 | — |
| Om Research LLC | Lancaster | California | 93534 | — |
| Atlantic Urology Medical Group | Long Beach | California | 90806-2766 | — |
| Long Beach Clinical Trials, LLC | Long Beach | California | 90806 | — |
| American Institute of Research | Los Angeles | California | 90017 | — |
| Kaiser Permanente Los Angeles Medical Center | Los Angeles | California | 90027 | — |
| Southern California Permanente Medical Group | Los Angeles | California | 90027 | — |
| Comprehensive Urology | Los Angeles | California | 90048 | — |
| Veterans Affairs Greater Los Angeles HCS | Los Angeles | California | 90073 | — |
| VA Sacramento Medical Center | Mather | California | 95655 | — |
| Hoag Medical Group | Newport Beach | California | 92663 | — |
| Kaiser Permanente Vaccine Study Center | Oakland | California | 94612 | — |
| Empire Clinical Research, LLC | Pomona | California | 91767 | — |
| Inland Urology Medical Group | Pomona | California | 91767 | — |
| UC Davis Health System | Sacramento | California | 92647 | — |
| Northern California Research | Sacramento | California | 95821 | — |
| San Diego Sports Medicine & Family Health Center | San Diego | California | 92120 | — |
| Medical Associates Research Group, Inc. | San Diego | California | 92123 | — |
| California Kidney Specialists | San Dimas | California | 91773 | — |
| Prestige Medical Group | Santa Ana | California | 92705 | — |
| Millennium Clinical Trials LLC | Simi Valley | California | 93065 | — |
| San Antonio Regional Hospital | Upland | California | 91786 | — |
| Yale University | New Haven | Connecticut | 06510 | — |
| Ideal Clinical Research | Adventura | Florida | 33180 | — |
| Bay Pines VA Healthcare System | Bay Pines | Florida | 33744 | — |
| Nova Clinical Research, LLC | Bradenton | Florida | 34209 | — |
| Clinical Research of Brandon | Brandon | Florida | 33511 | — |
| Moore Clinical Reseach - Brandon Clinic | Brandon | Florida | 33511 | — |
| Florida Medical Center of Clearwater | Clearwater | Florida | 33755 | — |
| Innovative Research of West Florida, Incorporated | Clearwater | Florida | 33756 | — |
| Advanced Clinical Research Network | Coral Gables | Florida | 33134 | — |
| Prestige Clinical Research Center, Inc. | Coral Gables | Florida | 33134 | — |
| Accel Research Sites | DeLand | Florida | 32720 | — |
| Doral Medical Research | Doral | Florida | 33166 | — |
| Universal Axon Clinical Research | Doral | Florida | 33166 | — |
| Florida Medical Research Institute | Gainesville | Florida | 32607 | — |
| Indago Research & Health Center Inc | Hialeah | Florida | 33012 | — |
| Prestige Clinical Research | Homestead | Florida | 33030 | — |
| Multi Specialty Research Associates Inc | Lake City | Florida | 32055 | — |
| ClinCloud Clinical Research | Maitland | Florida | 32751 | — |
| Nova Clinical Research Center | Miami | Florida | 33124 | — |
| Finlay Medical Research | Miami | Florida | 33126 | — |
| Royal Care Medical Research Corporation | Miami | Florida | 33133 | — |
| Retreat Medical Research LLC | Miami | Florida | 33135 | — |
| Suncoast Research Group | Miami | Florida | 33135 | — |
| Continental Research | Miami | Florida | 33144-4273 | — |
| Dynamic Medical Research, LLC | Miami | Florida | 33144 | — |
| Florida International Medical Research | Miami | Florida | 33155 | — |
| Health- Life Research Inst | Miami | Florida | 33155 | — |
| Office of Dr. Marisela Gonzalez | Miami | Florida | 33155 | — |
| Felicidad Medical Research | Miami | Florida | 33185 | — |
| A and R Research Group | Miami | Florida | 33186 | — |
| Alpha Science Research | Miami | Florida | 33186 | — |
| Clinical NeuroScience Solutions Inc | Orlando | Florida | 32801 | — |
| Omega Research Consultants | Orlando | Florida | 32808 | — |
| Pines Care Research Center Inc | Pembroke Pines | Florida | 33024 | — |
| Clinical Research of Central Florida | Plant City | Florida | 33563 | — |
| Care Access Research | Spring Hill | Florida | 34609 | — |
| Tampa General Hospital | Tampa | Florida | 33603 | — |
| Theia Clincial Research, LLC | Tampa | Florida | 33613 | — |
| Precision Research Institute | Tampa | Florida | 33614 | — |
| St. Joseph's Comprehensive Research Institute | Tampa | Florida | 33614 | — |
| Santos Research Center | Tampa | Florida | 33615 | — |
| Care Access Research | Tampa | Florida | 33625 | — |
| Agile Clinical Research Trials, LLC | Atlanta | Georgia | 30328 | — |
| Columbus Regional Research Institute | Columbus | Georgia | 31904 | — |
| Atlanta VA Medical Center | Decatur | Georgia | 30033 | — |
| Clinical Research Prime | Idaho Falls | Idaho | 83404 | — |
| Snake River Research, PLLC | Idaho Falls | Idaho | 83404 | — |
| Northwestern Medicine - Northwestern Memorial Hospital Galter Pavilion | Chicago | Illinois | 60611 | — |
| Jesse Brown VAMC Department of Surgery | Chicago | Illinois | 60612 | — |
| University Of Illinois | Chicago | Illinois | 60612 | — |
| Medisphere Medical Research Center, Llc | Evansville | Indiana | 47714 | — |
| Asha Clinical Research-Munster Llc | Hammond | Indiana | 46324 | — |
| Mishawaka Osteopathic Clinic/MOC Research | Mishawaka | Indiana | 46544 | — |
| Cypress Medical Research Center | Wichita | Kansas | 67226 | — |
| Tandem Clinical Research | Marrero | Louisiana | 70072 | — |
| KAMP Medical Research, Inc | Natchitoches | Louisiana | 71457 | — |
| Ochsner Medical Center | New Orleans | Louisiana | 70121 | — |
| Kaiser Permanente | Rockville | Maryland | 20852 | — |
| Floating Hospital For Children at Tufts Medical Center | Boston | Massachusetts | 02111 | — |
| West Roxbury Veterans Affairs Medical Center | West Roxbury | Massachusetts | 02132-4927 | — |
| Henry Ford Hospital | Detroit | Michigan | 48202 | — |
| William Beaumont Hospital | Royal Oak | Michigan | 48073 | — |
| MediSync Clinical Research | Petal | Mississippi | 39465 | — |
| Meridian Clinical Research, LLC | Grand Island | Nebraska | 68803 | — |
| Be Well Clinical Studies | Lincoln | Nebraska | 68516 | — |
| Meridian Clinical Research, LLC | Norfolk | Nebraska | 68701 | — |
| Hope Research Institute | Las Vegas | Nevada | 89106 | — |
| Sierra Clinical Research | Las Vegas | Nevada | 89106 | — |
| Excel Clinical Research | Las Vegas | Nevada | 89109 | — |
| VA Sierra Nevada Health Care System | Reno | Nevada | 89509 | — |
| I.D. Care, Inc. | Hillsborough | New Jersey | 08844 | — |
| Holy Name Medical Center | Teaneck | New Jersey | 07666 | — |
| Meridian Clinical Research, LLC | Binghamton | New York | 13901 | — |
| Meridian Clinical Research, LLC | Endwell | New York | 13760 | — |
| Manhattan Medical Research | New York | New York | 10016 | — |
| Montefiore Medical Center | The Bronx | New York | 10467 | — |
| Durham VAMC | Durham | North Carolina | 27705 | — |
| Carolina Institute for Clinical Research | Fayetteville | North Carolina | 28303 | — |
| ECU Health Vidant Medical Center | Greenville | North Carolina | 27834 | — |
| Plains Clinical Research | Fargo | North Dakota | 58104 | — |
| Kroger Health | Centerville | Ohio | 45458 | — |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44106 | — |
| Remington Davis Inc | Columbus | Ohio | 43215 | — |
| Kroger Health | Englewood | Ohio | 45322 | — |
| The Little Clinic | Englewood | Ohio | 45322 | — |
| Comprehensive Internal Medicine | Wooster | Ohio | 44691 | — |
| Tekton Research Inc. | Yukon | Oklahoma | 73099 | — |
| Kaiser Permanente | Portland | Oregon | 97227 | — |
| Capital Area Research | Camp Hill | Pennsylvania | 17011 | — |
| Reading Hospital | West Reading | Pennsylvania | 19611 | — |
| Hugh D. Durrence, MD, PC | Charleston | South Carolina | 29412 | — |
| Waterway Familiy Medicine | Little River | South Carolina | 29566 | — |
| Novel Research LLC | Bellaire | Texas | 77401 | — |
| Global Medical Research - Dallas | Dallas | Texas | 75224 | — |
| Medical City Dallas | Dallas | Texas | 75230 | — |
| North Texas Infectious Diseases Consultants | Dallas | Texas | 75246 | — |
| Digestive Health Associates | Houston | Texas | 77024 | — |
| EPIC Clinical Research | Lewisville | Texas | 75057 | — |
| SMS Clinical Research LLC | Mesquite | Texas | 75149 | — |
| Be Well Clinical Studies | Round Rock | Texas | 78681 | — |
| Audie L Murphy Memorial Va Ho | San Antonio | Texas | 78229 | — |
| Sherman Clinical Research | Sherman | Texas | 75092 | — |
| Lone Peak Family Medicine | Draper | Utah | 84020 | — |
| Clinical Alliance for Research and Education | Annandale | Virginia | 22003-7347 | — |
| Charlottesville Medical Research Center, LLC | Charlottesville | Virginia | 22911 | — |
| Infectious Disease Associates of Central Virginia | Lynchburg | Virginia | 24501 | — |
| IACT - Suffolk Multispecialty Research | Suffolk | Virginia | 23435 | — |
| Selma Medical Associates | Winchester | Virginia | 22601 | — |
| Multicare Institute For Research & Innovation - Rockwood Clinic - Cheney | Cheney | Washington | 99004 | — |
| Exemplar Research, Inc | Morgantown | West Virginia | 26505 | — |
| Marshfield Clinic | Marshfield | Wisconsin | 54449 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 232 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04899336, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 28, 2026 · Synced Oct 23, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04899336 live on ClinicalTrials.gov.