A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)
Public ClinicalTrials.gov record NCT04929223. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase I/Ib Global, Multicenter, Open-label Umbrella Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)
Study identification
- NCT ID
- NCT04929223
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 1
- Lead sponsor
- Hoffmann-La Roche
- Industry
- Enrollment
- 542 participants
Conditions and interventions
Conditions
Interventions
- Atezolizumab Drug
- Bevacizumab Drug
- Cetuximab Drug
- Divarasib Drug
- FOLFIRI Drug
- FOLFOX Drug
- FoundationOne®Liquid CDx Diagnostic Test
- Inavolisib Drug
- SY-5609 Drug
- Tiragolumab Drug
Drug · Diagnostic Test
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 21, 2021
- Primary completion
- Aug 30, 2030
- Completion
- Aug 30, 2030
- Last update posted
- Apr 26, 2026
2021 – 2030
United States locations
- U.S. sites
- 30
- U.S. states
- 17
- U.S. cities
- 27
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| UAB Comprehensive Cancer Center | Birmingham | Alabama | 35233 | Withdrawn |
| Mayo Clinic Arizona | Phoenix | Arizona | 85259 | Completed |
| City of Hope Comprehensive Cancer Center | Duarte | California | 91010 | Active, not recruiting |
| cCare | Encinitas | California | 92024 | Withdrawn |
| USC Norris Cancer Center | Los Angeles | California | 90033 | Completed |
| Cedars-Sinai Medical Center | Los Angeles | California | 90048 | Active, not recruiting |
| UCLA | Los Angeles | California | 90095 | Recruiting |
| Hoag Memorial Hospital Presbyterian | Newport Beach | California | 92663 | Withdrawn |
| Stanford Cancer Center | Stanford | California | 94305-5820 | Completed |
| University of Colorado Cancer Center | Aurora | Colorado | 80045 | Active, not recruiting |
| Yale Cancer Center | New Haven | Connecticut | 06520 | Recruiting |
| Eastern Ct Hema/Onco Assoc | Norwich | Connecticut | 06360 | Recruiting |
| Mayo Clinic in Florida | Jacksonville | Florida | 32224 | Withdrawn |
| Moffitt Cancer Center | Tampa | Florida | 33612 | Active, not recruiting |
| Mary Bird Perkins Cancer Ctr | Baton Rouge | Louisiana | 70809 | Recruiting |
| Massachusetts General Hospital | Boston | Massachusetts | 02114-2621 | Completed |
| Karmanos Cancer Institute | Detroit | Michigan | 48201 | Withdrawn |
| Mayo Clinic Rochester | Rochester | Minnesota | 55902 | Recruiting |
| New York Cancer & Blood Specialists - New Hyde Park | New Hyde Park | New York | 11042-1116 | Recruiting |
| New York Cancer and Blood Specialists-Central Park Hematology & Oncology | New York | New York | 10028 | Recruiting |
| New York Cancer & Blood Specialists | Port Jefferson Station | New York | 11776 | Recruiting |
| New York Cancer & Blood Specialists - Bronx | The Bronx | New York | 10469-5930 | Recruiting |
| Duke University Medical Center | Durham | North Carolina | 27710 | Completed |
| Hematology Oncology Salem | Salem | Oregon | 97301 | Active, not recruiting |
| UPMC - Hillman Cancer Center | Pittsburgh | Pennsylvania | 15232 | Active, not recruiting |
| Sarah Cannon Research Institute / Tennessee Oncology | Nashville | Tennessee | 37203 | Completed |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | Completed |
| Lumi Research | Kingwood | Texas | 77339 | Withdrawn |
| Swedish Cancer Inst. | Seattle | Washington | 98104 | Completed |
| Medical Oncology Associates | Spokane | Washington | 99208 | Withdrawn |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 46 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04929223, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 26, 2026 · Synced May 8, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04929223 live on ClinicalTrials.gov.