A Study to Assess the Safety, Efficacy, and Pharmacokinetics of Multiple Doses of ION224
Public ClinicalTrials.gov record NCT04932512. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
An Adaptive Two-Part Phase 2, Multi-Center, Randomized, Double Blind, Placebo-Controlled Study to Assess the Safety, Efficacy, and Pharmacokinetics of Multiple Doses of ION224 Administered Once Monthly in Adult Subjects With Confirmed Non-Alcoholic Steatohepatitis
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to assess the effect of multiple ION224 doses when administered by subcutaneous (SC) injection for 49 weeks (end of the treatment \[EOT\]) on non-alcoholic steatohepatitis (NASH) histologic improvement and to assess the effect on liver steatosis by magnetic resonance imaging-determined proton density fat fraction (MRI-PDFF), additional changes in NASH histologic features, liver biochemistry tests, and plasma lipid profile.
Study identification
- NCT ID
- NCT04932512
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 160 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 17, 2021 (Actual)
- Primary completion
- Jan 10, 2024 (Actual)
- Completion
- Feb 28, 2024 (Actual)
- Last update posted
- Nov 27, 2024
2021 – 2024
United States locations
- U.S. sites
- 50
- U.S. states
- 16
- U.S. cities
- 46
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Arizona Liver Health-Chandler | Chandler | Arizona | 85224 | — |
| Arizona Liver Health | Glendale | Arizona | 85306 | — |
| Arizona Liver Health | Tucson | Arizona | 85712 | — |
| Arkansas Gastroenterology - North Little Rock | North Little Rock | Arkansas | 72117 | — |
| GW Research, Inc. | Chula Vista | California | 91910 | — |
| National Research Institute - Gardena | Gardena | California | 90247 | — |
| National Research Institute | Huntington Park | California | 90255 | — |
| National Research Institute | Los Angeles | California | 90057 | — |
| National Research Institute Panorama City | Panorama City | California | 91402 | — |
| National Research Institute - Santa Ana | Santa Ana | California | 92704 | — |
| South Denver Gastroenterology, PC | Englewood | Colorado | 80113 | — |
| Excel Medical Clinical Trials, LLC | Boca Raton | Florida | 33434 | — |
| Tampa Bay Medical Research, Inc. | Clearwater | Florida | 33761 | — |
| Southwest General Medical Center | Fort Myers | Florida | 33907 | — |
| Evolution Clinical Trials, INC | Hialeah Gardens | Florida | 33016 | — |
| ClinCloud, LLC. | Maitland | Florida | 32751 | — |
| Advanced Pharma CR, LLC | Miami | Florida | 33147 | — |
| La Salud Research | Miami | Florida | 33155 | — |
| Entrust Clinical Research | Miami | Florida | 33176 | — |
| Floridian Clinical Research, LLC. | Miami Lakes | Florida | 33016 | — |
| Sensible Healthcare, LLC | Ocoee | Florida | 34761 | — |
| Covenant Metabolic Specialists, LLC | Sarasota | Florida | 34240 | — |
| Metabolic Research Institute, Inc. | West Palm Beach | Florida | 33401 | — |
| Gastrointestinal Specialists of Georgia | Marietta | Georgia | 30060 | — |
| Tandem Clinical Research GI | Houma | Louisiana | 70363 | — |
| Tandem Clinical Research GI, LLC. | Marrero | Louisiana | 70072 | — |
| Tandem Clinical Research GI | Metairie | Louisiana | 70006 | — |
| Delta Research Partners | Monroe | Louisiana | 71201 | — |
| Louisiana Research Center, LLC | Shreveport | Louisiana | 71105 | — |
| Southern Therapy and Advanced Research | Jackson | Mississippi | 39216 | — |
| Advanced Research Institute | Reno | Nevada | 89511 | — |
| Clarity Clinical Research | East Syracuse | New York | 13057 | — |
| Tandem Clinical Research GI, LLC. | New York | New York | 10033 | — |
| Cumberland Research Associates, LLC | Fayetteville | North Carolina | 28304 | — |
| Aventiv Research, Inc. | Columbus | Ohio | 43213 | — |
| Clinical Research Institute of Ohio | Westlake | Ohio | 44145 | — |
| WR-ClinSearch, LLC | Chattanooga | Tennessee | 37421 | — |
| Pinnacle Clinical Research | Austin | Texas | 78757 | — |
| South Texas Research Institute | Brownsville | Texas | 78520 | — |
| Dallas Diabetes Research Center | Dallas | Texas | 75230 | — |
| Velocity Clinical Research | Dallas | Texas | 75230 | — |
| South Texas Research Institute | Edinburg | Texas | 78539 | — |
| R&H Clinical Research, Inc. | Katy | Texas | 77494 | — |
| DHR Health Institute for Research and Development | McAllen | Texas | 78504 | — |
| Quality Research, Inc. | San Antonio | Texas | 78209 | — |
| Pinnacle Clinical Research | San Antonio | Texas | 78229 | — |
| Advanced Research Institute | Ogden | Utah | 84405 | — |
| Granger Medical Clinic | Riverton | Utah | 84096 | — |
| Advanced Research Institute | Sandy City | Utah | 84092 | — |
| Manassas Clinical Research Center | Manassas | Virginia | 20110 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 1 non-U.S. site.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04932512, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Nov 27, 2024 · Synced Oct 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04932512 live on ClinicalTrials.gov.