Guselkumab in Active Psoriatic Arthritis Participants With Inadequate Response/Intolerance to One Prior Anti-TNF Alpha Agent
Public ClinicalTrials.gov record NCT04936308. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3B, Multicenter, Randomized, Double-blind, Placebo-controlled Study Evaluating the Efficacy and Safety of Guselkumab Administered Subcutaneously in Participants With Active Psoriatic Arthritis Who Had an Inadequate Response and/or Intolerance to One Prior Anti-Tumor Necrosis Factor Alpha Agent
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate the efficacy of guselkumab treatment in participants with active psoriatic arthritis (PsA) and inadequate response (IR) and/or intolerance to a prior anti-tumor necrosis factor (TNF) by assessing the reduction in signs and symptoms of PsA.
Study identification
- NCT ID
- NCT04936308
- Recruitment status
- Completed
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 453 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 28, 2021 (Actual)
- Primary completion
- Oct 28, 2024 (Actual)
- Completion
- Jul 2, 2026 (Actual)
- Last update posted
- Aug 20, 2026
2021 – 2026
United States locations
- U.S. sites
- 50
- U.S. states
- 22
- U.S. cities
- 49
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Arthritis Associates | Mountain Brook | Alabama | 35223 | — |
| Arizona Arthritis and Rheumatology Research PLLC 2 | Avondale | Arizona | 85392 | — |
| Arizona Arthritis and Rheumatology Research PLLC 3 | Flagstaff | Arizona | 86001-6218 | — |
| Arizona Arthritis and Rheumatology Research PLLC | Mesa | Arizona | 85210 | — |
| Arizona Arthritis and Rheumatology Research PLLC 1 | Phoenix | Arizona | 85032 | — |
| Arizona Arthritis and Rheumatology Associates | Sun City | Arizona | 85351 | — |
| Southern Arizona VA Healthcare System | Tucson | Arizona | 85723 | — |
| Unity Health-White County Medical Center | Searcy | Arkansas | 72143 | — |
| Newport Huntington Medical Group | Huntington Beach | California | 92648 | — |
| Medvin Clinical Research 2 | Thousand Oaks | California | 91360 | — |
| Medvin Clinical Research | Tujunga | California | 91042 | — |
| Clinical Research Center of Connecticut | Danbury | Connecticut | 06810 | — |
| Bay Pines VA Healthcare System | Bay Pines | Florida | 33744 | — |
| Clinical Research of West Florida | Clearwater | Florida | 33765 | — |
| Omega Research Consultants | DeBary | Florida | 32713 | — |
| Advanced Clinical Research of Orlando | Ocoee | Florida | 34761 | — |
| Integral Rheumatology And Immunology Specialists | Plantation | Florida | 33324 | — |
| Clinical Research of West Florida 1 | Tampa | Florida | 33606 | — |
| Florida Medical Clinic, P.A. | Zephyrhills | Florida | 33542 | — |
| Great Lakes Clinical Trials | Chicago | Illinois | 60640 | — |
| Clinic of Robert Hozman | Skokie | Illinois | 60076 | — |
| The Arthritis and Diabetes Clinic | Monroe | Louisiana | 71203 | — |
| Johns Hopkins University | Baltimore | Maryland | 21224 | — |
| Klein And Associates M D P A | Hagerstown | Maryland | 21740 | — |
| Great Lakes Center of Rheumatology | Lansing | Michigan | 48911 | — |
| Arthritis and Rheumatology Center of MI | Okemos | Michigan | 48864 | — |
| Clinical Research Institute of Michigan, LLC | Saint Clair Shores | Michigan | 48081 | — |
| St. Paul Rheumatology P A | Eagan | Minnesota | 55121 | — |
| Arthritis Consultants | St Louis | Missouri | 63141 | — |
| Arthritis Rheumatic And Back Disease Associates | Voorhees Township | New Jersey | 08043 | — |
| Albuquerque Center for Rheumatology | Albuquerque | New Mexico | 87102 | — |
| Arthritis and Osteoperosis Associates of New Mexico | Las Cruces | New Mexico | 88011 | — |
| Buffalo Rheumatology and Medicine PLLC | Orchard Park | New York | 14127 | — |
| DJL Clinical Research, PLLC | Charlotte | North Carolina | 28211 | — |
| STAT Research, Inc. | Vandalia | Ohio | 45377 | — |
| Health Research of Oklahoma | Oklahoma City | Oklahoma | 73103 | — |
| Rheumatology Associates of Oklahoma | Oklahoma City | Oklahoma | 73116 | — |
| Dr. Ramesh Gupta | Memphis | Tennessee | 38119 | — |
| Precision Comprehensive Clinical Research Solutions | Colleyville | Texas | 76034 | — |
| Adriana Pop Moody MD Clinic PA | Corpus Christi | Texas | 78404 | — |
| Metroplex Clinical Research Center | Dallas | Texas | 75231 | — |
| Precision Comprehensive Clinical Research Solutions 1 | Fort Worth | Texas | 76107 | — |
| West Texas Clinical Research | Lubbock | Texas | 79424 | — |
| Southwest Rheumatology Research LLC | Mesquite | Texas | 75150 | — |
| Texas Rheumatology Care | Plano | Texas | 75024 | — |
| Advanced Rheumatology of Houston | The Woodlands | Texas | 77382 | — |
| DM Clinical Research | Tomball | Texas | 77375 | — |
| Arthritis And Osteoporosis Clinic | Waco | Texas | 76710 | — |
| Arthritis Northwest PLLC 1 | Spokane | Washington | 99204 | — |
| Rheumatology and Pulmonary Clinic | Beckley | West Virginia | 25801 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 119 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04936308, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 20, 2026 · Synced Oct 25, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04936308 live on ClinicalTrials.gov.