Study on an Investigational Yellow Fever Vaccine Compared With YF-VAX in Adults in the USA
Public ClinicalTrials.gov record NCT04942210. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Controlled Study of Immunogenicity and Safety of the Investigational vYF Candidate Vaccine in Comparison to YF-VAX in Adults
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The primary objective of the study is to demonstrate the non-inferiority of the antibody response in terms of seroconversion rate 28 days after vaccine administration of one dose of yellow fever vaccine (vYF) compared to the antibody response after one dose of the YF-VAX control vaccine in yellow fever naïve participants. The secondary objectives of the study are: * To describe the immune response to yellow fever in both vaccine groups before and after vYF or YF-VAX administration. * To describe the safety profile of vYF vaccine in comparison to the safety profile of the control YF-VAX. * To describe the biosafety profile of vYF in comparison to the biosafety profile of the control YF-VAX.
Study identification
- NCT ID
- NCT04942210
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 568 participants
Conditions and interventions
Conditions
Interventions
- Yellow fever vaccine (produced on serum-free Vero cells) Biological
- Yellow fever vaccine Biological
Biological
Eligibility (public fields only)
- Age range
- 18 Years to 60 Years
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 30, 2021
- Primary completion
- Jun 23, 2022
- Completion
- Jun 28, 2027
- Last update posted
- Sep 2, 2026
2021 – 2027
United States locations
- U.S. sites
- 11
- U.S. states
- 9
- U.S. cities
- 11
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Emory University Decatur- Site Number : 8400005 | Decatur | Georgia | 30030 | — |
| Velocity Clinical Research- New Orleans Site Number : 8400008 | New Orleans | Louisiana | 70119 | — |
| Johns Hopkins Bloomberg School of Public Health (JHSPH)- Site Number : 8400004 | Baltimore | Maryland | 21205 | — |
| Harvard University Medical School- Site Number : 8400002 | Boston | Massachusetts | 02115 | — |
| Saint Louis University- Site Number : 8400003 | St Louis | Missouri | 63104 | — |
| Meridian Clinical Research- Site Number : 8400009 | Omaha | Nebraska | 681134 | — |
| SUNY Upstate Medical University Global Health Institute Site Number : 8400006 | East Syracuse | New York | 13057 | — |
| New York University Langone Medical Center Site Number : 8400013 | New York | New York | 10016 | — |
| Rochester Clinical Research, Inc.- Site Number : 8400010 | Rochester | New York | 14609 | — |
| Velocity Clinical Research - Providence Site Number : 8400015 | East Greenwich | Rhode Island | 02818 | — |
| J Lewis Research Inc- Site Number : 8400012 | Salt Lake City | Utah | 84109 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04942210, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 2, 2026 · Synced Sep 8, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04942210 live on ClinicalTrials.gov.