Efficacy and Safety of KBP-5074 in Uncontrolled Hypertension and Moderate or Severe Chronic Kidney Disease (CKD)
Public ClinicalTrials.gov record NCT04968184. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3 Randomized Double-Blind Placebo-Controlled Multicenter Study to Assess the Efficacy and Safety of KBP-5074 Mineralocorticoid Receptor Antagonist in Subjects With Uncontrolled Hypertension and Moderate or Severe (Stage 3b/4) CKD
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This Phase 3, randomized, Double-blind, placebo-controlled, 2-arm, parallel-group, multicenter study with randomized withdrawal will evaluate the efficacy, safety, and durability of KBP-5074 in adult participants who have stage 3b/4 chronic kidney disease (CKD) (estimated glomerular filtration rate \[eGFR\] calculated using the Chronic Kidney Disease Epidemiology Collaboration \[CKD-EPI\] formula \[eGFR {EPI}\] ≥15 to ≤44 mL/min/1.73 m\^2) and uncontrolled hypertension (systolic blood pressure (SBP) ≥140 and \<180 mm Hg and taking 2 or more antihypertensive medications.
Study identification
- NCT ID
- NCT04968184
- Recruitment status
- Terminated
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 652 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 5, 2021 (Actual)
- Primary completion
- Jan 30, 2024 (Actual)
- Completion
- Jul 10, 2024 (Actual)
- Last update posted
- Sep 3, 2025
2021 – 2024
United States locations
- U.S. sites
- 65
- U.S. states
- 19
- U.S. cities
- 50
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| G & L Research, LLC | Foley | Alabama | 36535 | — |
| Apogee Clinical Research, LLC | Huntsville | Alabama | 35805 | — |
| Aventiv Research, Inc | Mesa | Arizona | 85210 | — |
| National Heart Institute | Beverly Hills | California | 90211-2285 | — |
| Amicis Research Center (Valencia) | Granada Hills | California | 91324 | — |
| Amicis Research Center | Granada Hills | California | 91344 | — |
| Amicis Research Center | Lancaster | California | 93534 | — |
| Renal Consultants Medical Group - Granada Hills | Northridge | California | 91325 | — |
| United Clinical Research and Innovations | South Gate | California | 90280 | — |
| Solano Kidney Care | Vacaville | California | 95687-3557 | — |
| Desert Cities Dialysis - Amethyst | Victorville | California | 92392 | — |
| Kidney and Hypertension Center | Victorville | California | 92395 | — |
| Davita Clinical Research-Hartford | Bloomfield | Connecticut | 06002 | — |
| Synergy Healthcare | Bradenton | Florida | 34208 | — |
| Homestead Associates in Research, Inc | Miami | Florida | 33032-8225 | — |
| Total Research Group | Miami | Florida | 33126-3422 | — |
| LCC Medical Research | Miami | Florida | 33126 | — |
| Oceane 7 Medical&Research Center, Inc. | Miami | Florida | 33144 | — |
| Allied Biomedical Research Institute | Miami | Florida | 33155 | — |
| South Florida Research Phase I-Iv, Inc. | Miami | Florida | 33166 | — |
| San Marcus Research Clinic, Inc. | Miami Lakes | Florida | 33014-5602 | — |
| Inpatient Research Clinic, LLC | Miami Lakes | Florida | 33014 | — |
| New Generation Of Medical Research | Naples | Florida | 34104 | — |
| Sarkis Clinical | Ocala | Florida | 34471 | — |
| Omega Research Orlando, LLC | Orlando | Florida | 32808 | — |
| Genesis Clinical Research | Tampa | Florida | 33603 | — |
| Santos Research Center CORP | Tampa | Florida | 33604 | — |
| Fides Clinical Research | Atlanta | Georgia | 30342 | — |
| Southeastern Clinical Research Institute, LLC | Augusta | Georgia | 30904 | — |
| Columbus Associates LLC | Columbus | Georgia | 31904-3650 | — |
| Central Georgia Kidney Specialists | Macon | Georgia | 31201-6863 | — |
| Clinical Investigation Specialists, Inc. | Gurney | Illinois | 60031 | — |
| Massachusetts General Hospital (MGH) - Renal Associates Clinic | Boston | Massachusetts | 02114 | — |
| InterMed Consultants | Edina | Minnesota | 55435-2129 | — |
| Healthcare Research Network | Hazelwood | Missouri | 63042 | — |
| Clinical Research Consultants | Kansas City | Missouri | 64111-5964 | — |
| St. Louis Heart and Vascular, P.C. (SLHV) - Christian Hospital Office | St Louis | Missouri | 63136-6111 | — |
| Healor Primary Care /CCT Research | Las Vegas | Nevada | 89102-1682 | — |
| DaVita Clinical Research (Nevada) | Las Vegas | Nevada | 89128 | — |
| NYC Health + Hospitals / Queens - Diabetes Center of Excellence | Jamaica | New York | 11432 | — |
| Mattoo & Bhat Medical Associates, PC | Ridgewood | New York | 11385 | — |
| Albert Einstein's College of Medicine | The Bronx | New York | 10461-1900 | — |
| Kidney Medical Associates, PLLC | The Bronx | New York | 10461-2710 | — |
| Mountain Kidney & Hypertension Associates (MKHA), P.A - Asheville | Asheville | North Carolina | 28801-4104 | — |
| Physicians East, PA | Greenville | North Carolina | 27834 | — |
| Eastern Nephrology Associates - Jacksonville | Jacksonville | North Carolina | 28546 | — |
| Eastern Nephrology Associates - New Bern | New Bern | North Carolina | 28562-5200 | — |
| North Carolina Nephrology P.A. | Raleigh | North Carolina | 27609-7511 | — |
| Brookview Hills Research Associates, LLC | Winston-Salem | North Carolina | 27103-7108 | — |
| Providence Health Partners-Center for Clinical Research | Dayton | Ohio | 45439 | — |
| Columbia Nephrology Associates, PA | Columbia | South Carolina | 29203-6476 | — |
| Knoxville Kidney Center, PLLC | Knoxville | Tennessee | 37923-3624 | — |
| Gamma Clinical Research Institute | Austin | Texas | 78503 | — |
| Davita Clinical Research El Paso | El Paso | Texas | 79925 | — |
| Kidney Consultants of El Paso, P.A. | El Paso | Texas | 79935 | — |
| DaVita Clinical Research Houston | Houston | Texas | 77004 | — |
| Pioneer Research Solutions, Inc. | Houston | Texas | 77099 | — |
| Clinical Advancement Center, PLLC | San Antonio | Texas | 78212-4738 | — |
| Urology San Antonio - North Central | San Antonio | Texas | 78229-3342 | — |
| DaVita Clinical Research | San Antonio | Texas | 78251 | — |
| Kidney Specialists of North Houston, PLLC | The Woodlands | Texas | 77384 | — |
| Davita Norfolk Square | Norfolk | Virginia | 23502 | — |
| Dominion Medical Associates, Inc. | Richmond | Virginia | 23219 | — |
| Clinical Investigation Specialists | Kenosha | Wisconsin | 53142 | — |
| Milwaukee Nephrologists, SC (Rich) | Wauwatosa | Wisconsin | 53226 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 150 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04968184, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 3, 2025 · Synced Oct 22, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT04968184 live on ClinicalTrials.gov.