A Study to Evaluate the Safety and Anti-cancer Activity of Loncastuximab Tesirine in Combination With Other Anti-cancer Agents in Participants With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma (LOTIS-7)
Public ClinicalTrials.gov record NCT04970901. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 1b Open-Label Study to Evaluate the Safety and Anti-cancer Activity of Loncastuximab Tesirine in Combination With Other Anti-cancer Agents in Patients With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma (LOTIS-7)
Study identification
- NCT ID
- NCT04970901
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 1
- Lead sponsor
- ADC Therapeutics S.A.
- Industry
- Enrollment
- 200 participants
Conditions and interventions
Conditions
Interventions
- Glofitamab Drug
- Loncastuximab Tesirine Drug
- Mosunetuzumab Drug
- Obinutuzumab Drug
- Polatuzumab Vedotin Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 16, 2022
- Primary completion
- Oct 29, 2026
- Completion
- Oct 28, 2027
- Last update posted
- Mar 12, 2026
2022 – 2027
United States locations
- U.S. sites
- 25
- U.S. states
- 18
- U.S. cities
- 22
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of California San Francisco - Fresno Center for Medical Education and Research | Clovis | California | 93611 | Recruiting |
| Scripps Health - Prebys Cancer Center | San Diego | California | 92103 | Recruiting |
| Sylvester Comprehensive Cancer Center | Miami | Florida | 33136 | Recruiting |
| Miami Cancer Institute | Miami | Florida | 33176 | Recruiting |
| Memorial Cancer Institute - Memorial Hospital West | Pembroke Pines | Florida | 33028 | Recruiting |
| Winship Cancer Institute of Emory University | Atlanta | Georgia | 30322 | Recruiting |
| The Blood and Marrow Transplant Group of Georgia | Atlanta | Georgia | 30342 | Recruiting |
| Mission Cancer + Blood - Mission Cancer Foundation | Des Moines | Iowa | 50309 | Recruiting |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | 02215 | Recruiting |
| Dana-Farber Cancer Institute | Boston | Massachusetts | 02215 | Recruiting |
| University of Minnesota | Minneapolis | Minnesota | 55455 | Recruiting |
| Columbia University Irving Medical Center | New York | New York | 10027 | Recruiting |
| Cleveland Clinic Main Campus | Cleveland | Ohio | 44195 | Recruiting |
| Oregon Health and Science University | Portland | Oregon | 97239 | Recruiting |
| Penn Medicine - Perelman Center for Advanced Medicine | Philadelphia | Pennsylvania | 19104 | Recruiting |
| Allegheny Health Network - West Penn Hospital | Pittsburgh | Pennsylvania | 15224 | Recruiting |
| Brown University Health - Rhode Island Hospital | Providence | Rhode Island | 02903 | Recruiting |
| Hollings Cancer Center | Charleston | South Carolina | 29425 | Completed |
| Avera Cancer Institute | Sioux Falls | South Dakota | 57105 | Withdrawn |
| Greco-Hainsworth Tennessee Oncology Centers for Research (GHCR) | Nashville | Tennessee | 37203 | Recruiting |
| Baylor University Medical Center | Dallas | Texas | 75246 | Recruiting |
| Huntsman Cancer Institute | Salt Lake City | Utah | 84112 | Recruiting |
| Emily Couric Clinical Cancer Center | Charlottesville | Virginia | 22903 | Recruiting |
| NEXT Virginia (Virginia Cancer Specialists) | Fairfax | Virginia | 22031 | Completed |
| Froedtert & Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 17 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04970901, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Mar 12, 2026 · Synced May 8, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04970901 live on ClinicalTrials.gov.