A Study of Amivantamab and Lazertinib in Combination With Platinum-Based Chemotherapy Compared With Platinum-Based Chemotherapy in Patients With Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non- Small Cell Lung Cancer After Osimertinib Failure
Public ClinicalTrials.gov record NCT04988295. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Open-Label, Randomized Study of Amivantamab and Lazertinib in Combination With Platinum-Based Chemotherapy Compared With Platinum-Based Chemotherapy in Patients With EGFR-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer After Osimertinib Failure
Study identification
- NCT ID
- NCT04988295
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Janssen Research & Development, LLC
- Industry
- Enrollment
- 776 participants
Conditions and interventions
Conditions
Interventions
- Amivantamab Drug
- Carboplatin Drug
- Lazertinib Drug
- Pemetrexed Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 16, 2021
- Primary completion
- Jul 9, 2023
- Completion
- Nov 29, 2027
- Last update posted
- May 7, 2026
2021 – 2027
United States locations
- U.S. sites
- 28
- U.S. states
- 17
- U.S. cities
- 26
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Southern Cancer Center, PC | Mobile | Alabama | 36608 | — |
| Arizona Oncology Associates | Tucson | Arizona | 85711 | — |
| City of Hope | Duarte | California | 91010 | — |
| Cedars Sinai Medical Center | Los Angeles | California | 90048 | — |
| University of California Irvine | Orange | California | 92868 | — |
| Rocky Mountain Cancer Centers | Colorado Springs | Colorado | 80907 | — |
| Holy Cross Hospital - Michael and Dianne Bienes Comprehensive Cancer Center | Fort Lauderdale | Florida | 33308 | — |
| University Cancer And Blood Center LLC | Athens | Georgia | 30607 | — |
| University of Mississippi Medical Center | Jackson | Mississippi | 39216 | — |
| Nebraska Cancer Specialists | Grand Island | Nebraska | 68803 | — |
| Astera Cancer Care | East Brunswick | New Jersey | 08816 | — |
| TriHealth Network | Cincinnati | Ohio | 45220 | — |
| Providence Portland Medical Center | Portland | Oregon | 97213 | — |
| Kaiser Permanente Northwest | Portland | Oregon | 97227 | — |
| Alliance Cancer Specialists | Horsham | Pennsylvania | 19044 | — |
| University of Pittsburgh Medical Center | Pittsburgh | Pennsylvania | 15232 | — |
| Baptist Cancer Center | Memphis | Tennessee | 38120 | — |
| Texas Oncology-Medical City Dallas | Dallas | Texas | 75230 | — |
| Texas Oncology Baylor Charles A Sammons Cancer Center | Dallas | Texas | 75246 | — |
| Texas Oncology | Grapevine | Texas | 76051 | — |
| Oncology Consultants Texas | Houston | Texas | 77030 | — |
| Texas Oncology - Northeast | Longview | Texas | 75601 | — |
| University of Vermont Medical Center | Burlington | Vermont | 05401 | — |
| University of Virginia | Charlottesville | Virginia | 22908 | — |
| Virginia Cancer Specialists | Fairfax | Virginia | 22031 | — |
| Blue Ridge Cancer Care | Wytheville | Virginia | 24382 | — |
| NorthWest Medical Specialties, PLLC | Puyallup | Washington | 98373 | — |
| Compass Oncology | Vancouver | Washington | 98684 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 221 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT04988295, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 7, 2026 · Synced May 10, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT04988295 live on ClinicalTrials.gov.