A Dose-Escalation and Expansion Study of BGB-16673 in Participants With B-Cell Malignancies

ClinicalTrials.gov ID: NCT05006716

Public ClinicalTrials.gov record NCT05006716. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 8, 2026, 10:48 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 1/2, Open-Label, Dose-Escalation and -Expansion Study of the Bruton Tyrosine Kinase Targeted Protein Degrader BGB-16673 in Patients With B-Cell Malignancies

Study identification

NCT ID: NCT05006716
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 1, Phase 2
Lead sponsor: BeOne Medicines; Industry
Enrollment: 614 participants

Conditions and interventions

Conditions

Interventions

BGB-16673 Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Sep 12, 2021
Primary completion: Oct 31, 2026
Completion: Oct 31, 2029
Last update posted: Apr 21, 2026

2021 – 2029

United States locations

U.S. sites: 30
U.S. states: 19
U.S. cities: 28

Facility	City	State	ZIP	Site status
University of Alabama At Birmingham Hospital	Birmingham	Alabama	35294-0004	Recruiting
Mayo Clinic Phoenix	Phoenix	Arizona	85054-4502	Completed
Honor Health Research Institute	Scottsdale	Arizona	85258-4566	Recruiting
University of Arizona Cancer Center	Tucson	Arizona	85724-0001	Recruiting
University of California San Diego (Ucsd) Moores Cancer Center	La Jolla	California	92093-1503	Recruiting
Stanford Medicine	Palo Alto	California	94304-2205	Recruiting
UCLA Santa Monica Cancer Care	Santa Monica	California	90404-2023	Recruiting
Uchealth North	Fort Collins	Colorado	80528-3413	Recruiting
Mayo Clinic Jacksonville	Jacksonville	Florida	32224-1865	Recruiting
Mount Sinai Comprehensive Cancer Center	Miami	Florida	33140-2840	Recruiting
Tampa General Hospital Cancer Institute	Tampa	Florida	33606-3571	Recruiting
Augusta University	Augusta	Georgia	30912-0002	Recruiting
Southeastern Regional Medical Center	Newnan	Georgia	30265-8001	Recruiting
Midwestern Regional Medical Center	Zion	Illinois	60099-2676	Completed
University of Iowa Hospitals and Clinics	Iowa City	Iowa	52242-1009	Recruiting
Mary Bird Perkins Cancer Center	Baton Rouge	Louisiana	70809-3738	Recruiting
American Oncology Partners of Maryland Pa	Bethesda	Maryland	20817-7847	Recruiting
Dana Farber Cancer Institute	Boston	Massachusetts	02215-5418	Recruiting
Karmanos Cancer Institute	Detroit	Michigan	48201-2013	Recruiting
Mayo Clinic Rochester	Rochester	Minnesota	55905-0001	Recruiting
Comprehensive Cancer Centers of Nevada	Las Vegas	Nevada	89169-3321	Recruiting
Roswell Park Comprehensive Cancer Center	Buffalo	New York	14203	Recruiting
Columbia University Medical Center	New York	New York	10032	Recruiting
Weill Cornell Medical College Newyork Presbyterian Hospital	New York	New York	10065-4870	Recruiting
Memorial Sloan Kettering Cancer Center Mskcc	New York	New York	10065-6800	Recruiting
Tennesse Oncology Chattanooga Downtown	Chattanooga	Tennessee	37404	Recruiting
Tennessee Oncology, Pllc Nashville	Nashville	Tennessee	37203	Recruiting
Md Anderson Cancer Center	Houston	Texas	77030-3907	Recruiting
Virginia Commonwealth University Massey Cancer Center	Richmond	Virginia	23298	Recruiting
Fred Hutchinson Cancer Research Center	Seattle	Washington	98109-4433	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 97 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05006716, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Apr 21, 2026 · Synced May 8, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05006716 live on ClinicalTrials.gov.

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