Combination Therapy for the Treatment of Diffuse Midline Gliomas

ClinicalTrials.gov ID: NCT05009992

Public ClinicalTrials.gov record NCT05009992. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 18, 2026, 6:01 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Combination Therapy Trial Using an Adaptive Platform Design for Children and Young Adults With Diffuse Midline Gliomas (DMGs) Including Diffuse Intrinsic Pontine Gliomas (DIPGs) at Initial Diagnosis, Post-Radiation Therapy and at Time of Progression

Study identification

NCT ID: NCT05009992
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2
Lead sponsor: University of California, San Francisco; Other
Enrollment: 360 participants

Conditions and interventions

Conditions

Interventions

DNX-2401 Drug
ONC201 Drug
Paxalisib Drug
Radiation Therapy Radiation

Drug · Radiation

Eligibility (public fields only)

Age range: 2 Years to 39 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Oct 19, 2021
Primary completion: Dec 30, 2027
Completion: Jun 29, 2029
Last update posted: Dec 16, 2025

2021 – 2029

United States locations

U.S. sites: 19
U.S. states: 17
U.S. cities: 19

Facility	City	State	ZIP	Site status
University of Alabama at Birmingham	Birmingham	Alabama	35233	Recruiting
Children's Hospital Los Angeles	Los Angeles	California	90027	Recruiting
University of California, San Diego / Rady Children's Hospital, San Diego	San Diego	California	92123	Recruiting
University of California, San Francisco	San Francisco	California	94143	Recruiting
Children's National Hospital	Washington D.C.	District of Columbia	20010	Recruiting
Ann & Robert H. Lurie Children's Hospital of Chicago	Chicago	Illinois	60611	Recruiting
Indiana University Riley Children's Hospital	Indianapolis	Indiana	46202	Recruiting
Johns Hopkins University	Baltimore	Maryland	21287	Recruiting
Dana-Farber Cancer Institute Harvard University	Boston	Massachusetts	02215-6024	Recruiting
University of Michigan	Ann Arbor	Michigan	48109	Recruiting
Children's Hospital Minnesota	Minneapolis	Minnesota	55404	Recruiting
Washington University in St. Louis	St Louis	Missouri	63110	Recruiting
Hackensack Meridian Health	Hackensack	New Jersey	07601	Recruiting
New York University	New York	New York	10016	Recruiting
Duke University	Durham	North Carolina	27708	Recruiting
Nationwide Children's Hospital	Columbus	Ohio	43205	Recruiting
Children's Hospital of Philadelphia	Philadelphia	Pennsylvania	19104	Recruiting
University of Utah	Salt Lake City	Utah	84101	Recruiting
Seattle Children's Hospital	Seattle	Washington	98101	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 13 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05009992, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Dec 16, 2025 · Synced May 18, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT05009992 live on ClinicalTrials.gov.

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