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Completed Phase 2 Interventional Results available

A Study to Learn About the Study Medicine (Elranatamab) in Participants With Multiple Myeloma That Has Come Back After Responding to Treatment or Has Not Responded to Treatment

ClinicalTrials.gov ID: NCT05014412

Public ClinicalTrials.gov record NCT05014412. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Oct 23, 2026, 8:06 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A PHASE 1/2, OPEN-LABEL, MULTICENTER STUDY TO EVALUATE A DOSING REGIMEN WITH TWO STEP-UP PRIMING DOSES AND LONGER DOSING INTERVALS OF ELRANATAMAB (PF-06863135) MONOTHERAPY IN PARTICIPANTS WITH RELAPSED/REFRACTORY MULTIPLE MYELOMA

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The purpose of the study (Part 1 and Part 2) is to evaluate the safety of a step-up dosing approach (starting with low doses followed by higher doses) of the study medicine (elranatamab) in participants with multiple myeloma that has come back after responding to treatment or has not responded to treatment (relapsed/refractory multiple myeloma). This study will also look at the safety and efficacy of different doses of elranatamab, as well as different intervals between doses. Participants in the study will receive elranatamab as an injection under the skin at the study clinic. After the initial step-up doses, participants will start receiving one dose every week. The frequency of clinic visits for injections may then decrease over time. Participation will be at least two years.

Study identification

NCT ID
NCT05014412
Recruitment status
Completed
Study type
Interventional
Phase
Phase 2
Lead sponsor
Pfizer
Industry
Enrollment
86 participants

Conditions and interventions

Interventions

Drug

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Oct 7, 2021 (Actual)
Primary completion
Jun 15, 2023 (Actual)
Completion
Dec 12, 2025 (Actual)
Last update posted
Feb 10, 2026

2021 – 2025

United States locations

U.S. sites
35
U.S. states
11
U.S. cities
23
Facility City State ZIP Site status
Mayo Clinic Hospital Phoenix Arizona 85054 —
Mayo Clinic Scottsdale Arizona 85259 —
Poudre Valley Hospital Fort Collins Colorado 80524 —
Cancer Care & Hematology - Fort Collins Fort Collins Colorado 80528 —
Poudre Valley Health System (PVHS) Fort Collins Colorado 80528 —
UCHealth Cancer Care & Hematology - Greeley Greeley Colorado 80634 —
UCHealth Cancer Care & Hematology - Loveland Loveland Colorado 80538 —
UF Health Shands Cancer Hospital Gainesville Florida 32608 —
UF Health Shands Hospital Pharmacy Investigational Drug Service - Main Gainesville Florida 32610 —
UF Health Shands Hospital Gainesville Florida 32610 —
East Jefferson General Hospital Bone Marrow Transplant Clinic Metairie Louisiana 70006 —
East Jefferson General Hospital Metairie Louisiana 70006 —
Tulane University New Orleans Louisiana 70112 —
The Regents of the University of Michigan Ann Arbor Michigan 48109 —
University of Michigan Ann Arbor Michigan 48109 —
Henry Ford Hospital Detroit Michigan 48202 —
MSK Basking Ridge Basking Ridge New Jersey 07920 —
MSK Monmouth Middletown New Jersey 07748 —
MSK Bergen Montvale New Jersey 07645 —
MSK Commack Commack New York 11725 —
MSK Westchester Harrison New York 10604 —
Memorial Sloan Kettering Cancer Center - Investigational Drug Service Pharmacy Long Island City New York 11101 —
Memorial Sloan Kettering Cancer Center - David H. Koch Center for Cancer Care (74th Street). New York New York 10021 —
Memorial Sloan Kettering Cancer Center New York New York 10065 —
MSK Nassau Uniondale New York 11553 —
Cleveland Clinic Taussig Cancer Institute Cleveland Ohio 44195 —
Fox Chase Cancer Center Philadelphia Pennsylvania 19111 —
St. David's South Austin Medical Center Austin Texas 78704 —
Texas Oncology-South Austin Austin Texas 78745 —
Blood Cancer and Stem Cell Transplant Clinic San Antonio Texas 78229 —
Methodist Healthcare System of San Antonio dba Methodist Hospital San Antonio Texas 78229 —
Methodist Hospital Investigational Pharmacy San Antonio Texas 78229 —
Methodist Plaza Clinical Trials Office San Antonio Texas 78229 —
Huntsman Cancer Institute, University of Utah Salt Lake City Utah 84112 —
University of Utah Salt Lake City Utah 84112 —

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 15 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT05014412, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Feb 10, 2026 · Synced Oct 23, 2026

Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.

Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT05014412 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →