CD40 Agonist, Flt3 Ligand, and Chemotherapy in HER2 Negative Breast Cancer

ClinicalTrials.gov ID: NCT05029999

Public ClinicalTrials.gov record NCT05029999. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Apr 20, 2026, 7:27 AM EDT

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Official title

Phase 1 Pilot Study With Dose Expansion of Chemotherapy in Combination With CD40 Agonist and Flt3 Ligand in Metastatic HER2 Negative Breast Cancer

Study identification

NCT ID: NCT05029999
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 1
Lead sponsor: University of Texas Southwestern Medical Center; Other
Enrollment: 30 participants

Conditions and interventions

Conditions

Interventions

CDX-1140 Drug
CDX-301 Drug
PLD Chemotherapy Drug

Drug

Eligibility (public fields only)

Age range: 18 Years to 99 Years
Sex: All
Healthy volunteers: Not listed

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Apr 19, 2022
Primary completion: Apr 19, 2026
Completion: Apr 19, 2026
Last update posted: Aug 12, 2025

2022 – 2026

United States locations

U.S. sites: 7
U.S. states: 5
U.S. cities: 6

Facility	City	State	ZIP	Site status
University of Chicago Comprehensive Cancer Center	Chicago	Illinois	60637	Recruiting
Johns Hopkins University	Baltimore	Maryland	21287	Recruiting
University of North Carolina	Chapel Hill	North Carolina	27599	Recruiting
Sarah Cannon Research Institute	Nashville	Tennessee	37203	Withdrawn
Texas Oncology, P.A.	Dallas	Texas	75251	Active, not recruiting
UT Southwestern Medical Center	Dallas	Texas	75390	Recruiting
The University of Texas Health Science Center at San Antonio	San Antonio	Texas	78229	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT05029999, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Aug 12, 2025 · Synced Apr 20, 2026

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The complete protocol, eligibility criteria, and contact information for NCT05029999 live on ClinicalTrials.gov.

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