A Study of Calderasib (MK-1084) in KRAS Mutant Advanced Solid Tumors (MK-1084-001)
Public ClinicalTrials.gov record NCT05067283. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 1, Open-label, Multicenter Study to Assess Safety, Tolerability, PK, and Efficacy of MK-1084 as Monotherapy and as Part of Various Combination Therapies in Participants With KRAS G12C Mutant Advanced Solid Tumors
Study identification
- NCT ID
- NCT05067283
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 1
- Enrollment
- 830 participants
Conditions and interventions
Conditions
Interventions
- 5-fluorouracil Drug
- Calderasib Drug
- Pembrolizumab Biological
- carboplatin Drug
- cetuximab Biological
- leucovorin Drug
- oxaliplatin Drug
- pemetrexed Drug
Drug · Biological
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 16, 2021
- Primary completion
- Feb 24, 2030
- Completion
- Feb 24, 2030
- Last update posted
- May 3, 2026
2021 – 2030
United States locations
- U.S. sites
- 6
- U.S. states
- 6
- U.S. cities
- 6
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Moffitt Cancer Center ( Site 0261) | Tampa | Florida | 33612 | Recruiting |
| START Midwest ( Site 0267) | Grand Rapids | Michigan | 49546 | Recruiting |
| John Theurer Cancer Center at Hackensack University Medical Center ( Site 0260) | Hackensack | New Jersey | 07601 | Recruiting |
| Laura and Isaac Perlmutter Cancer Center ( Site 0270) | New York | New York | 10016 | Completed |
| NEXT Virginia ( Site 0271) | Fairfax | Virginia | 22031 | Recruiting |
| MEDICAL COLLEGE OF WISCONSIN-Cancer Center Clinical Trials Office ( Site 0262) | Milwaukee | Wisconsin | 53226 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 68 non-U.S. sites.
Recently updated Advanced Solid Tumors trials
Other public records listing Advanced Solid Tumors. Sorted by last update posted; newest first. Not a recommendation.
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- NCT07524348: A Trial to Investigate the Safety of E303 in Participants With Advanced Refractory Solid Tumors Recruiting
- NCT06792552: A Phase I Study of SIM0505 in Participants With Advanced Solid Tumors Recruiting
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05067283, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 3, 2026 · Synced May 8, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05067283 live on ClinicalTrials.gov.