Intensity Modulated Proton or X-Ray Therapy After Surgery for Treatment of Head and Neck Cancer, the HEADLIGHT Study
Public ClinicalTrials.gov record NCT05075980. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
HEADLIGHT: Hypofractionated Proton Therapy for Head and Neck Cancers
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This clinical trial studies how well intensity modulated proton therapy (IMPT) or intensity modulated X-ray (radiation) therapy (IMRT) works after surgery in treating patients with head and neck cancer. IMPT is a type of radiation therapy that allows for the most accurate application of proton radiation to the tumor and has the potential to reduce treatment-related side effects. IMRT is a type of 3-dimensional radiation therapy that uses computer-generated images to show the size and shape of the tumor. Thin beams of x-ray radiation of different intensities are aimed at the tumor from many angles. This type of radiation therapy reduces the damage to healthy tissue near the tumor. IMPT may work as well as IMRT after surgery in treating patients with head and neck cancer.
Study identification
- NCT ID
- NCT05075980
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 174 participants
Conditions and interventions
Conditions
- Head and Neck Carcinoma
- Head and Neck Carcinoma of Unknown Primary
- Hypopharyngeal Carcinoma
- Laryngeal Carcinoma
- Metastatic Malignant Neoplasm in the Lymph Nodes
- Nasal Cavity Carcinoma
- Oral Cavity Carcinoma
- Oropharyngeal Carcinoma
- Paranasal Sinus Carcinoma
- Salivary Gland Carcinoma
- Cutaneous Squamous Cell Carcinoma of the Head and Neck
- Locally Advanced Cutaneous Squamous Cell Carcinoma of the Head and Neck
Interventions
- Cisplatin Drug
- Intensity-Modulated Proton Therapy Procedure
- Quality-of-Life Assessment Other
- Questionnaire Administration Other
- Computed Tomography Procedure
- Magnetic Resonance Imaging Procedure
- Positron Emission Tomography Procedure
- Biospecimen Collection Procedure
- Intensity-Modulated Radiation Therapy Radiation
Drug · Procedure · Other + 1 more
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 15, 2022
- Primary completion
- Feb 4, 2028
- Completion
- Mar 4, 2031
- Last update posted
- Jul 15, 2026
2022 – 2031
United States locations
- U.S. sites
- 9
- U.S. states
- 4
- U.S. cities
- 9
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Mayo Clinic Hospital in Arizona | Phoenix | Arizona | 85054 | — |
| Mayo Clinic in Arizona | Scottsdale | Arizona | 85259 | — |
| Mayo Clinic in Florida | Jacksonville | Florida | 32224 | — |
| Mayo Clinic Health System in Albert Lea | Albert Lea | Minnesota | 56007 | — |
| Mayo Clinic Health System - Mankato | Mankato | Minnesota | 56001 | — |
| Mayo Clinic Radiation Therapy - Northfield | Northfield | Minnesota | 55057 | — |
| Mayo Clinic in Rochester | Rochester | Minnesota | 55905 | — |
| Mayo Clinic Health System - Eau Claire | Eau Claire | Wisconsin | 54701 | — |
| Mayo Clinic Health System - Franciscan Healthcare | La Crosse | Wisconsin | 54601 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT05075980, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 15, 2026 · Synced Sep 8, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT05075980 live on ClinicalTrials.gov.